Burli R.W.,BioFocus Chesterford Research Park |
Thomas E.,BioFocus Chesterford Research Park |
Beaumont V.,080 Center Drive
Topics in Medicinal Chemistry | Year: 2010
Neurodegenerative disorders are devastating for patients and their social environment. Their etiology is poorly understood and complex. As a result, there is clearly an urgent need for therapeutic agents that slow down disease progress and alleviate symptoms. In this respect, interference with expression and function of multiple gene products at the epigenetic level has offered much promise, and histone deacetylases play a crucial role in these processes. This review presents an overview of the biological pathways in which these enzymes are involved and illustrates the complex network of proteins that governs their activity. An overview of small molecules that interfere with histone deacetylase function is provided. © 2010 Springer-Verlag Berlin Heidelberg.