Agency: Cordis | Branch: FP7 | Program: NOE | Phase: ICT-2007.3.5 | Award Amount: 5.23M | Year: 2008
Today Biophotonics is an emerging multidisciplinary research area, embracing all light-based technologies applied to the life sciences and medicine. Enhancing diagnosis, therapy and follow-up care, Biophotonics drives the trend towards personalized medicine and plays a crucial role in limiting health-care costs and appropriately addressing the accelerating challenges associated with population aging and the consequent increase in age-related diseases. Its economic and socio-political importance is reflected in the enormous annual growth rates of industries in this field.\nAs a Network of Excellence, PHOTONICS4LIFE aims to provide a coherent framework for research in the strongly fragmented field of Biophotonics in Europe. One of the challenging tasks of PHOTONICS4LIFE is therefore to map and to overview the research and technological developments across these various subdisciplines with their manifold but not sufficiently explored interdependences.\nPHOTONICS4LIFE targets to bridge the gaps between the different research communities ranging from Physics and Engineering via Chemistry and Physical Chemistry to Biology and Medicine for the analysis of cell processes, for non- and minimally-invasive diagnosis and therapy and for point-of-care diagnostics.\nPHOTONICS4LIFE aims to link the expertise of research institutes towards the SMEs and large companies in order to foster Biophotonics research and to strengthen the economical competitiveness of Europe in the global Biophotonics market.\nPHOTONICS4LIFE is composed of partners standing on the forefront of Biophotonics research and covering together the broadness of fields including the related ethical issues. The partners will work towards a durable integration, provide a critical mass that will act as a nucleus for integrated fundamental and applied Biophotonics research across Europe and reach out to the international scene. With its objectives, PHOTONICS4LIFE is aimed directly at improving the quality of life.
Khlebtsov N.,Chernyshevsky Saratov State University |
Dykman L.,Russian Academy of Sciences
Chemical Society Reviews | Year: 2011
Recent advances in wet chemical synthesis and biomolecular functionalization of gold nanoparticles have led to a dramatic expansion of their potential biomedical applications, including biosensorics, bioimaging, photothermal therapy, and targeted drug delivery. As the range of gold nanoparticle types and their applications continues to increase, human safety concerns are gaining attention, which makes it necessary to better understand the potential toxicity hazards of these novel materials. Whereas about 80 reports on the in vivo biodistribution and in vitro cell toxicity of gold nanoparticles are available in the literature, there is lack of correlation between both fields and there is no clear understanding of intrinsic nanoparticle effects. At present, the major obstacle is the significant discrepancy in experimental conditions under which biodistribution and toxicity effects have been evaluated. This critical review presents a detailed analysis of data on the in vitro and in vivo biodistribution and toxicity of most popular gold nanoparticles, including atomic clusters and colloidal particles of diameters from 1 to 200 nm, gold nanoshells, nanorods, and nanowires. Emphasis is placed on the systematization of data over particle types and parameters, particle surface functionalization, animal and cell models, organs examined, doses applied, the type of particle administration and the time of examination, assays for evaluating gold particle toxicity, and methods for determining the gold concentration in organs and distribution of particles over cells. On the basis of a critical analysis of data, we arrive at some general conclusions on key nanoparticle parameters, methods of particle surface modification, and doses administered that determine the type and kinetics of biodistribution and toxicity at cellular and organismal levels (197 references). © 2011 The Royal Society of Chemistry.
Khlebtsov N.G.,Chernyshevsky Saratov State University |
Dykman L.A.,Russian Academy of Sciences
Journal of Quantitative Spectroscopy and Radiative Transfer | Year: 2010
Nanoparticle plasmonics is a rapidly emerging research field that deals with the fabrication and optical characterization of noble metal nanoparticles of various size, shape, structure, and tunable plasmon resonances over VIS-NIR spectral band. The recent simultaneous advances in synthesis, characterization, electromagnetic simulation, and surface functionalization of plasmonic nanoparticles by biospecific molecular probes have led to a perfect publication storm in discoveries and potential biomedical applications of plasmon-resonant nanoparticle bioconjugates. Here, we present an overview of these topics. First, we discus basic wet-chemical routes to fabricate conjugates of gold, silver, or composite particles with controllable size, shape, structure and with surface functionalization by biospecific molecules. Second, we consider the single-particle dipole and multipole optics and coupled plasmonic nanoparticle arrays. Finally, we discus application of plasmonic bioconjugates to such fields as homogeneous and solid-phase assays, biomedical sensing and imaging, biodistribution and toxicity aspects, drug delivery and plasmonic photothermal therapy. © 2009 Elsevier Ltd. All rights reserved.
Dykman L.,Russian Academy of Sciences |
Khlebtsov N.,Chernyshevsky Saratov State University
Chemical Society Reviews | Year: 2012
Gold nanoparticles (GNPs) with controlled geometrical, optical, and surface chemical properties are the subject of intensive studies and applications in biology and medicine. To date, the ever increasing diversity of published examples has included genomics and biosensorics, immunoassays and clinical chemistry, photothermolysis of cancer cells and tumors, targeted delivery of drugs and antigens, and optical bioimaging of cells and tissues with state-of-the-art nanophotonic detection systems. This critical review is focused on the application of GNP conjugates to biomedical diagnostics and analytics, photothermal and photodynamic therapies, and delivery of target molecules. Distinct from other published reviews, we present a summary of the immunological properties of GNPs. For each of the above topics, the basic principles, recent advances, and current challenges are discussed. © The Royal Society of Chemistry 2012.
Glukhova O.E.,Chernyshevsky Saratov State University
Journal of Molecular Modeling | Year: 2011
A mathematical model of the new nanodevice based on the K +@C60@tubeC740 hybrid carbon compound and named as the nanoautoclave is presented. The operation of the nanoautoclave is demonstrated by the example of modeling the synthesis process of stable dimers of the C20 and C28 fullerenes. Energetic characteristics of the (C20)2[2 + 2] dimer correspond to those calculated before. Parameters of the (C28)2[1 + 1] dimer have been calculated for the first time. The dimerization process is simulated by the method of molecular dynamics with the tight-binding description of interatomic interactions. © 2010 Springer-Verlag.
Davoyan A.R.,Chernyshevsky Saratov State University |
Popov V.V.,Chernyshevsky Saratov State University |
Nikitov S.A.,Chernyshevsky Saratov State University
Physical Review Letters | Year: 2012
We suggest a novel possibility for electrically tunable terahertz near-field enhancement in flatland electronic materials supporting two-dimensional plasmons, including recently discovered graphene. We employ electric-field effect modulation of electron density in such materials and induce a periodic plasmonic lattice with a defect cavity. We demonstrate that the plasmons resonantly excited in such a periodic plasmonic lattice by an incident terahertz radiation can strongly pump the cavity plasmon modes leading to a deep subwavelength concentration of terahertz energy, beyond λ/1000, with giant electric-field enhancement factors up to 104, which is 2 orders of magnitude higher than achieved previously in metal-based terahertz field concentrators. © 2012 American Physical Society.
Popov V.V.,Chernyshevsky Saratov State University
Applied Physics Letters | Year: 2013
The physics of terahertz rectification by periodic two-dimensional electron plasma is discussed. Two different effects yielding terahertz rectification are studied: the plasmonic drag and plasmonic ratchet. Ultrahigh responsivity of terahertz rectification by periodic two-dimensional electron plasma in semiconductor heterostructures and graphene is predicted. © 2013 AIP Publishing LLC.
Popov V.V.,Chernyshevsky Saratov State University
Journal of Infrared, Millimeter, and Terahertz Waves | Year: 2011
Physics of plasma oscillations and basic principles of plasmonic detection of terahertz radiation in the grating-gate transistor structures with two-dimensional electron channels are considered. It is shown that the grating-gate-transistor plasmonic detectors can be efficiently coupled to terahertz radiation. Plasmonic detection response considerably increases if the electron density in the grating-gate transistor structure is spatially modulated. © Springer Science+Business Media, LLC 2011.
Agency: Cordis | Branch: FP7 | Program: MC-IIFR | Phase: FP7-PEOPLE-IIF-2008 | Award Amount: 15.00K | Year: 2011
Current clinically approved methods for detection of Cardiovascular Disease have a number of associated disadvantages and limitations. All methods have some reliability issues and most are based on detection of plaque. Once plaque already exists however, disease may have been getting progressively worse for decades. Methods based on detection of plaque are therefore not able to detect the disease in the early stages. Better diagnostic methods, especially for early detection, are therefore urgently needed and will provide a great improvement on existing methods. A major problem in establishing better diagnostic methods is the large scientific gap which exists between clinicians and scientists, making communication extremely difficult. This proposal will use the unique skill-set of Russian scientist with formidable clinical knowledge and the highest level of mathematical and computational skills to transfer clinical knowledge to the scientific community. This proposal will use this unique skill-set to establish the necessary scientific basis to pursue new methods to detect cardiovascular disease earlier and more reliably than presently possible. The essence of the approach is that material changes must occur at the inner boundary of the artery in the very earliest stages of disease. This novel approach will use advanced asymptotic long wave methods developed by the UK host and will determine changes at the inner boundary through changes to the expected dispersion spectrum. The results from this project will provide the urgently required framework to supply a scientific benchmark, enabling new diagnostic equipment to be developed; this will not only save and improve quality of life, it will significantly reduce the financial cost of treatment and long term care of cardiovascular disease.
Glukhova O.,Chernyshevsky Saratov State University |
Slepchenkov M.,Chernyshevsky Saratov State University
Nanoscale | Year: 2012
Electronic and adsorptive properties of deformed graphene are investigated in the current work. Armchair and zigzag nanoribbons are the subject of the study. The axial compression was a deforming load. A calculation method for the local stress field was developed. This method was based on the quantum model of the finite graphene nanoribbon and empirical calculation method of the single atom energy. The stress field of the deformed ribbon was calculated by means of the suggested methodology. The effects of the atomic grid curvature on the adsorptive capacity of graphene and the hydrogenation process was investigated by means of the developed method. The prediction of the appearance of defects on covalent C-C bond breakdown is also performed. © 2012 The Royal Society of Chemistry.