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Song W.-Q.,Chenzhou No1 Peoples Hospital Group | Tan Q.,Central South University | Ge X.-F.,Central South University | Xia Z.-H.,Central South University
International Journal of Ophthalmology | Year: 2011

AIM: To observe contrast sensitivity (CS) function recovery in postoperative senile cataract patients and to discuss the influencing factors of recovering visual quality. METHODS: Controlling investigative method was applied. Experimental group: 54 cases (55 eyes) were operated with Phaco + Sensar AR40e (17 eyes), Phaco + Bausch&Lomb LI61SE(18 eyes) or Phaco + Array SA40N (20 eyes) lens implantation. The optical materials of Sensar AR40e intraocular lens was hydrophobic acrylate, those of the other 2 types of intraocular lens were intraocular silicone. Controlling group: 12 cases (24 eyes) were aged matching volunteers, eliminating ophthalmology and other body diseases. The patients and the volunteer were examined their contrast sensitivity under the best-corrected visual acuity in dark and bright conditions. RESULTS: The CS of Array SA40N group was lower than the normal control group in any other spatial frequencies excluding 0.8cpd in bright conditions. The CS of Bausch&Lomb LI61SE group was lower than the normal control group in any other spatial frequency excluding 0.8cpd. The CS of Sensar AR40e group was lower than the normal control group in any other spatial frequencies excluding 0.8cpd and 1. 5cpd. The CS of Array SA40N group was lower than the other two intraocular lens groups excluding 12cpd and 20cpd. There were no significant differences in all spatial frequencies between the CS of Sensar AR40e group and Bausch&Lomb LI61SE group. CONCLUSION: The CS of intraocular lens was significantly lower than that of the aged matching normal control group; the CS of the multifocal intraocular lens was significantly lower than that of the monofocal intraocular lens in the high frequency area; there were no significant differences between the CS of hydrophobic acrylic lens and silicone intraocular lens. Source


Xie H.L.,University of South China | Li Z.Y.,Zhejiang University | Gan R.L.,University of South China | Li X.J.,Chenzhou No1 Peoples Hospital Group | And 3 more authors.
Journal of Digestive Diseases | Year: 2010

Objective: To gain insight into the molecular events of lymph node metastasis of human gastric carcinoma. Methods: The gene expression profile of five matched primary gastric carcinomas and their lymph node metastases was analyzed by complementary DNA (cDNA) microarray. Differential genes were identified in the metastatic and corresponding primary tumor pairs. Among the differentially expressed genes, carbonic anhydrase II (CAII) and insulin-like growth factor binding protein 4 (IGFBP 4) genes were detected by RT-PCR. CTTN protein expression was examined by tissue microarray. Results: There was a high expression (over twofold) of 44 genes and a low expression (under twofold) of 32 genes in lymph node metastasis compared with primary gastric carcinoma, respectively. CAII mRNA was downregulated and IGFBP 4 mRNA was upregulated in paired lymph node metastases of gastric carcinomas. The overexpression of CTTN protein was related to the lymph node metastasis and the clinical stage of gastric carcinomas. Conclusion: This study showed that there is a low expression of genes relative to growth signal and immune response in lymph node metastases, and a high expression of genes relative to growth factor, cell cycle, cell motility and adhesion in lymph node metastases compared with primary gastric carcinomas. The expression of CTTN was related to the invasion and metastasis of gastric cancer. © 2010 The Authors. Journal compilation © 2010 Chinese Medical Association Shanghai Branch, Chinese Society of Gastroenterology and Blackwell Publishing Asia Pty Ltd. Source

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