Chengdu University of Technology is a Chinese state university, which is located in Chengdu, Sichuan, China. CDUT was established in 1956 on the basis of geo-related faculties from Chongqing University, Nanjing University, Northwest University, Beijing Institute of Geology and Changchun College of Geology . Wikipedia.
Chengdu University of Technology | Date: 2017-02-22
Disclosed are compounds or pharmaceutically acceptable salts thereof having the following general formula: R-Linker-R. The compounds or pharmaceutically acceptable salts thereof provided by the present invention are used as Bcr-Abl diploid inhibitors, which can effectively inhibit the activity of tyrosine kinase, are applicable in treating diseases concerning abnormal activation of such kinases, and have good effects in treating malignant tumors. The method for preparing such inhitors is simple and convenient, has low cost, and has good application prospects.
Chengdu University of Technology | Date: 2015-04-16
Disclosed are compounds or pharmaceutically acceptable salts thereof having the following general formula: R-Linker-R. The compounds or pharmaceutically acceptable salts thereof provided by the present invention are used as Bcr-Abl diploid inhibitors, which can effectively inhibit the activity of tyrosine kinase, are applicable in treating diseases concerning abnormal activation of such kinases, and have good effects in treating malignant tumors. The method for preparing such inhibitors is simple and convenient, has low cost, and has good application prospects.
Zhu Y.,Chengdu University of Technology
International Journal of Mechanical Sciences | Year: 2017
In a previous work, the author has systemically investigated the thermo-mechanical coupling response of 316L stainless steel tube under cyclic tension/compression condition. In this work, such thermo-mechanical coupling behaviors of the material were experimentally studied under strain-controlled cyclic free-end torsion condition. It is concluded from the experimental results that: the material presents a cyclic hardening-softening response in strain-controlled cyclic torsion; a temperature oscillation with the period of half a cycle time was observed during cyclic deformation; the heat source vanishes in elastic torsion while it is non-vanishing in elastic tension/compression reported in the previous work. Then, the experimental results were simulated by a pre-developed thermo-mechanically coupled cyclic constitutive model. It is shown that the simulations match the experimental data reasonably. © 2017 Elsevier Ltd
Zeng Y.,Chengdu University of Technology
Journal of Cellular and Molecular Medicine | Year: 2017
The glycocalyx covers the human mammalian cells and plays important roles in stroke, inflammation and atherosclerosis. It has also been shown to be involved in endothelial mechanotransduction of shear stress. Shear stress induces the remodelling of the major component of the glycocalyx including glypican-1, a cell membrane heparan sulphate proteoglycan. Other factors, such as sphingosine-1-phosphate (S1P), protect the glycocalyx against syndecan-1 ectodomain shedding and induce the synthesis of heparan sulphate. In this study, we reviewed the role of shear stress and S1P in glycocalyx remodelling and revealed that the glycocalyx is a critical signalling platform, integrating the extracellular haemodynamic forces and chemical signalling, such as S1P, for determining the fate of endothelial cells and vascular diseases. This review integrated our current understanding of the structure and function of the glycocalyx and provided new insight into the role of the glycocalyx that might be helpful for investigating the underlying biological mechanisms in certain human diseases, such as atherosclerosis. © 2017 Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine.
Pharmaceutical Factory of Chengdu Huasun Group Inc. and Chengdu University of Technology | Date: 2013-07-10
Disclosed are a panaxatriol saponins enteric pellet and a method for preparing same, and a capsule comprising the enteric pellet. The enteric pellet comprises a core having a diameter of 20-24 mesh consisting of panaxatriol saponins and pharmaceutical necessities, and an enteric coating layer over the core, wherein the panaxatriol saponins, the pharmaceutical necessities and the enteric coating layer are in a weight ratio of 100:(165-208):(45-65). Preferred pharmaceutical necessities consist of microcrystalline cellulose, starch and polyvidone K30 in a weight ratio of (80-100):(80-100):(5-6), or consist of microcrystalline cellulose, micronized silica gel and polyvidone K30 in a weight ratio of 100:100:8. Preferred enteric pellet has the following components and weight ratio thereof of panaxatriol saponins : microcrystalline cellulose : starch : polyvidone K30 : enteric coating layer = 100:93:93:5.7:58.3, or panaxatriol saponins : microcrystalline cellulose : micronized silica gel : polyvidone K30 : enteric coating layer = 100:100:100:8:62. The enteric pellet is prepared by fluid-bed method or extrusion-spheronization method.
Ren R.,Chengdu University of Technology
Hypertension | Year: 2016
Subjective daytime sleepiness is considered a significant risk factor of hypertension in patients with obstructive sleep apnea (OSA). In this study, our goal was to examine the joint effect on hypertension of OSA and objective daytime sleepiness measured by the multiple sleep latency test (MSLT). A total of 1338 Chinese patients with OSA and 484 primary snorers were included in the study. All subjects underwent 1 night polysomnography followed by MSLT. The MSLT values were classified into 3 categories: >8 minutes, 5 to 8 minutes, and <5 minutes. Hypertension was defined based either on direct blood pressure measures or on diagnosis by a physician. After controlling for confounders, OSA combined with MSLT of 5 to 8 minutes increased the odds of hypertension by 95% (odds ratio, 1.95; 95% confidence interval, 1.10–3.46), whereas OSA combined with MSLT <5 minutes further increased the odds of hypertension by 111% (odds ratio, 2.11; 95% confidence interval, 1.22–3.31) compared with primary snorers with MSLT >8 minutes. In stratified analyses, the association of hypertension with MSLT in OSA patients was seen among both sexes, younger ages, both obese and nonobese patients, and patients with and without subjective excessive daytime sleepiness. We conclude that objective daytime sleepiness is associated with hypertension in patients with OSA. © 2016 American Heart Association, Inc
Li T.,Chengdu University of Technology
Bulletin of Engineering Geology and the Environment | Year: 2012
Many tunnels along the Dujiangyan to Wenchuan highway, located near the epicenter of the 2008 Wenchuan earthquake in China, were damaged severely. The characteristics of the tunnel failures were analyzed and categorized as avalanches and landsliding near the tunnels, cracking of the tunnel portals, collapse of the liner and surrounding rock, cracking and dislocation of the liner, uplift and cracking of the ground, deformation and cracking of the preliminary bracing. The main geological factors influencing the tunnel damage are secondary fractures of earthquake faults, sudden change in soil and rock type, weak rocks and the variable geo-stresses in the host material. The tunnel portals and their slopes, unless fully integrated into the tunnel structures and sufficiently reinforced, are likely to suffer significant distress as a consequence of seismic events. The main mitigation measures proposed are the use of reinforced concrete in the secondary lining in the area of fault zones and injection grouting to reduce the differences where there are sudden changes in the character of the host material. © 2011 Springer-Verlag.
Huang R.,Chengdu University of Technology
Bulletin of Engineering Geology and the Environment | Year: 2012
Large-scale landslides in western China are famous for their size, complex formation mechanism and serious destruction. Data were collected from some typical large-scale landslides in mainland China in the 20th century. A number of geo-mechanical models have been identified: the "three sections" model (sliding; tension cracking; shearing), "retaining wall collapse", "horizontal-pushing" in horizontal strata; large-scale toppling in counter-inclined strata; the creep-bending-shearing model etc. Large-scale rock landslides are generally accompanied by sudden brittle failure of the "locking section" along the potential sliding surface. The paper discusses the importance of this "locking section" which is key to assessing slope geohazard and to the development of control/mitigation measures. © 2011 Springer-Verlag.
Yu B.,Chengdu University of Technology
Journal of Sedimentary Research | Year: 2011
Subaqueous channels are formed on subaqueous fans in oceans or lakes by turbidity currents. The subaqueous channels are laid on gentle slopes and are bounded by levees. The sediment in subaqueous channels differs in grain-size distribution in the channel and levee. The process by which a turbidity current flowing over an initially featureless surface creates channels by itself is still incompletely understood. I have addressed the following research question: which combination of turbidity-current factors leads to channelization? In this paper the discharge of turbidity currents, the bottom gradient of the turbidity currents, the settling velocity of sediment, and the range of grain-sizes of the sediment in the turbidity currents were considered for the turbidity-current factors. Some factors such as the sediment concentration of turbidity current, the width of the fan, the kinematic viscosity of water, the density of the particles, and the density of the ambient fluid were not considered. This meant that I had to determine the proper interaction of the following factors: the discharge of turbidity currents, the bottom gradient of the turbidity currents, the settling velocity of sediment, and the range of grain-sizes of the sediment in the turbidity currents. The following (model) testing arrangements were used: a test basin 6 m long with a slope 5 m long that can be inclined between 20% and 0.3%, sediments with four different densities and seven different grain-size distributions were used, with various discharges of turbidity currents. The model tests showed that subaqueous depositional channels can be formed when the dimensionless discharge is an empirical linear function of the gradient of subaqueous fans. The dimensionless discharge of the turbidity current is the product of the square of the grain size and the settling velocity of the sediment, divided by the discharge of the turbidity current. Formulas were developed to narrow down the range of sediment and flow conditions required for channel formation. It is shown that these formulas are applicable not only on the laboratory scale but also on the field scale. © 2011, SEPM.
Chengdu University of Technology | Date: 2015-05-28
A data-oriented information technology system has a data registration center, a data resource pool and a data service unit layer. The data resource pool is a space for storing data; the data registration center is used for constructing uniform data definition, naming and registration functions to realize data management; the data service unit layer includes a plurality of data-oriented, relevant function-encapsulated data function units, and data function units are used for accessing data in the data resource pool; when they first accesses the data resource pool, when the data registration center takes the initiative to refresh the information and informs the data function units, and when abnormalities occur during accessing, it is necessary to obtain information required for access from the data registration center, so that they can access data in the data resource pool.