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Wu L.,University of Sichuan | Li M.,University of Sichuan | Liu D.,Chengdu Seventh Peoples Hospital | Jiang M.,University of Sichuan | And 5 more authors.
Oncology Letters | Year: 2014

In China, the incidence of nasopharyngeal carcinoma (NPC) and tuberculosis remains high. Additionally, there has been a marked increase in the prevalence of gout. In recent years, there has been an increase in the number of co-existing diseases. To the best of our knowledge, there have been no previous cases reported in the literature with regard to patients suffering from NPC complicated with pulmonary tuberculosis and gout. The present study describes the case of a 59-year-old male with this condition. The patient received a combination of anti-tumor, anti-tuberculosis and anti-gout therapies, and experienced no severe adverse reactions during treatment. At present, the patient's Eastern Cooperative Oncology Group performance status is good, there has been no local recurrence or distant metastasis of the NPC, and the pulmonary tuberculosis and gout are well controlled. The aim of this study was to provide insight into the treatment of patients suffering from co-existing conditions. Source

Chen P.,Chengdu Seventh Peoples Hospital | Zhu J.,University of Sichuan | Liu D.-Y.,Chengdu Seventh Peoples Hospital | Li H.-Y.,Hainan Provincial Peoples Hospital | And 2 more authors.
Medical Oncology | Year: 2014

The expression of survivin, an inhibitor of apoptosis can be seen in most tumors and is correlated with the angiogenic factor vascular endothelial growth factor (VEGF). But little is known about their contribution in small-cell lung cancer (SCLC). This study was designed to investigate the expression of survivin and VEGF in SCLC, and to explore their correlation with clinical-pathological feature and prognosis. Forty-five patients with pathological histology of SCLC were entered into this study. Forty-five cases of matched adjacent non-tumor samples and 10 samples of operated patients with benign lung tumor were also included as control. The expression of survivin and VEGF was detected by immunohistochemistry (IHC, SP). These two sets of data were processed and tested for correlation with major patients' characteristics, and overall survival. The correlations between survivin and VEGF expressions and the clinical- pathological features were evaluated by chi-square test. The correlation between survivin and VEGF expressions was analyzed by Spearman's rank correlation test; the overall survival was analyzed by the Kaplan-Meier method; and the relationship between clinical and pathological features and overall survival was analyzed by the Cox proportional hazard models. Positive expression rate of survivin and VEGF was significantly higher in SCLC than those of adjacent non-tumor tissues and benign lung tumor tissues (73.3 vs. 15.6 vs. 0 %, P < 0.05) and (75.6 vs. 20 vs. 0 %, P < 0.05), respectively. Survivin and VEGF expressions were significantly associated with lymph node metastasis (P = 0.003, 0.011) and clinical stage (P = 0.006, 0.021). The expression of survivin was significantly coincident with the expression of VEGF (r = 0.644, P = 0.000). The median overall survival in survivin positive group and VEGF positive group was significantly shorter than those in survivin negative and VEGF negative group, respectively (log-rank P = 0.000). Moreover, multivariate analysis showed that survivin expression (HR 0.224; 95 % CI 0.074-0.675; P = 0.008) and VEGF expression (HR 0.172; 95 % CI 0.054-0.559; P = 0.003) were statistically independent predictive factors of poorer prognosis for SCLC patients. Our results indicated that survivin and VEGF were over-expressed in small-cell lung cancer, each of them may be an independent poor prognostic factor. © 2013 Springer Science+Business Media New York. Source

Huang X.-H.,Chengdu Seventh Peoples Hospital | He K.,Chengdu Seventh Peoples Hospital
Chinese Journal of Tissue Engineering Research | Year: 2015

BACKGROUND: A number of studies have been conducted on the prevention of enamel demineralization in orthodontic treatment, but no work has been carried out on the comparative studies addressing manual toothbrush, orthodontic fur V brush and interdental brush. OBJECTIVE: To compare the efficacy of manual toothbrush, orthodontic fur V brush and interdental brush on enamel decalcification during orthodontic treatment. METHODS: Adolescents, aged 12 to 17 years old, were randomly and averagely divided into three groups: manual toothbrush, orthodontic fur V brush, and interdental brush groups. Enamel decalcification index and augmenter of enamel decalcification index were examined and calculated by the same orthodontist before treatment and 1 year later. RESULTS AND CONCLUSION: There was no statistical difference in the enamel decalcification index among the three groups at the beginning (P > 0. 05). After 1 year of treatment, the enamel decalcification index of each group was higher than that at the beginning (P < 0. 05); the enamel decalcification index and augmenter of enamel decalcification index in the three groups were ranked as follows: orthodontic Fur V toothbrush group < manual toothbrush < interdental toothbrush group, and there was a statistical significant difference among the three groups (P < 0. 05). Orthodontic fur V brush is proved to have advantages over manual toothbrush and interdental brush in the respect of controlling enamel decalcification, and interdental brush has no good effect on preventing enamel demineralization while it is used alone. © 2015 Journal of Clinical Rehabilitative Tissue Engineering Research. All rights reserved. Source

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