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Qi Q.,Shandong University | Wang W.,Chengdu Second Peoples Hospital | Li T.,Shandong University | Zhang Y.,Shandong University | Li Y.,Shandong University
Respirology | Year: 2015

Background and objective Bronchiectasis is a chronic respiratory disease with diverse causes that may differ in clinical features and thus treatment options. However, few large-scale studies on the aetiology of bronchiectasis are currently available. This study aims to determine aetiology and clinical features of bronchiectasis in a Chinese Han population. Methods This prospective study enrolled adult patients diagnosed with bronchiectasis as confirmed by high-resolution computed tomography at five general hospitals in Shandong from January 2010 to August 2014. Causes of bronchiectasis were sought by analysis of clinical history and auxiliary examinations (including serum immunoglobulin determination, saccharin test, Aspergillus skin prick test, autoantibody detection and electronic bronchoscopy). Results A total of 476 adult patients with bronchiectasis were included, and all patients were of Chinese Han ethnicity. Idiopathic (66.0%) was the most common cause, followed by post-tuberculosis (16.0%). Other uncommon causes included post-infective (3.8%), immunodeficiency (3.8%), allergic bronchopulmonary aspergillosis (4.0%), rheumatic diseases (4.4%) and primary ciliary dyskinesia (0.9%). Patients with post-tuberculosis bronchiectasis had a higher frequency of upper lobe involvement (P < 0.05). Cylindrical bronchiectasis was the most common type of all causes, with varicose bronchiectasis occurring more frequently in post-tuberculosis bronchiectasis and allergic bronchopulmonary aspergillosis (P < 0.05). However, patients with different causes did not differ in lung function and sputum isolation rate of Pseudomonas aeruginosa (P > 0.05). Conclusions In a Chinese Han population in Shandong, idiopathic bronchiectasis is the most common form of bronchiectasis followed by post-tuberculosis bronchiectasis. Patients with different causes differ in distribution and pattern of bronchiectasis on computed tomography. © 2015 Asian Pacific Society of Respirology.

Cheng L.,Key Laboratory of Transplant Engineering and Immunology | Duan X.,Chengdu Second Peoples Hospital | Duan X.,University of Sichuan | Xiang Z.,University of Sichuan | And 5 more authors.
Applied Surface Science | Year: 2012

Many studies have shown that calcium phosphate ceramics (CP) have osteoconductive and osteoinductive properties; however, the exact mechanism of bone induction has not yet been reported. This study was performed to investigate if destroying immunological function will influence osteogenesis, to explain the mechanism which is unclear. In this study, twenty C57BL/6 mice were divided into two groups (n = 10), in group 1, a hydroxyapatite/β- tricalcium phosphate (HA/β-TCP) ceramic was implanted into both the left and right leg muscles of each mouse; in group 2, ten mice experienced lethal irradiation, then were injected bone marrow (BM) cells from green fluorescent protein (GFP) transgenic mice by tail veil, after bone marrow transplantation (BMT), heart, liver, spleen, lung, kidney, and muscle were harvested for biological analysis, after the GFP chimera model was established successfully, the same HA/β-TCP ceramic was implanted into both leg muscles of each mouse immediately after irradiation. 45 and 90 days after implantation, the ceramics of the two groups were harvested to perform with hematoxylin and eosin (HE) and immunohistochemistry (IHC) staining; the results showed that there was no bone formation in group 2, while new bone tissues were detected in group 1. Our findings suggest that the BM cell from GFP transgenic mice is a good biomarker and it could set a good platform for chimera model; it also shows that BM cell is one of cell resources of bone induction, and destruction of immune function will impede osteoinduction by CP. Overall, our results may shed light on clear mechanism study of bone induction in the future. © 2012 Elsevier B.V. All rights reserved.

Liu H.,Sun Yat Sen University | Li S.,Sun Yat Sen University | Wang J.,Sun Yat Sen University | Wang T.,Chengdu Second Peoples Hospital | And 4 more authors.
Spine | Year: 2014

Study Design. A retrospective and radiological study of degenerative spinal diseases. Objective. To explore the changes in spinopelvic sagittal alignment after lumbar instrumentation and fusion of degenerative spinal diseases. Summary of Background Data. Efforts have been paid to clarify the ideal postoperative sagittal profi le for degenerative spinal diseases. However, little has been published about the actual changes of sagittal alignment after lumbar lordosis reconstruction. Methods. Radiographical analysis of 83 patients with spinal degeneration was performed by measuring sagittal parameters before and after operations. Comparative studies of sagittal parameters between short (1 level) and long ( ≥ 2 level) instrumentation and fusion were performed. Different variances ( δ ) of these sagittal parameters before and after operations were calculated and compared. Correlative study and linear regression were performed to establish the relationship between variances. Results. No signifi cant changes were shown in the short-fusion group postoperatively. In the long-fusion group, postoperative lumbar lordosis (LL) and sacral slope (SS) were signifi cantly increased; pelvic tilt (PT), sagittal vertical axis (SVA), pelvic incidence minus lumbar lordosis, and PT/SS were signifi cantly decreased. Different variances of δ LL, δ SS, δ PT, δ SVA,δ (pelvic incidence - LL), and δ PT/SS were signifi cantly greater in the long-fusion group than the short-fusion group. Close correlations were mainly shown among δ LL, δ PT, and δ SVA. Linear regression equations could be developed ( δ PT = - 0.185 × δ LL - 7.299 and δ SVA = - 0.152 δ LL - 1.145). Conclusion. In degenerative spinal diseases, long instrumentation and fusion ( ≥ 2 levels) provides more effi cient LL reconstruction. PT, SS, and SVA improve corresponding to LL in a linear regression model. Linear regression equations could be developed and used to predict PT and SVA change after long instrumentation and fusion for LL reconstruction. © 2014 Lippincott Williams & Wilkins.

Zhang Y.-G.,University of Sichuan | Wang Y.-T.,Chengdu Second Peoples Hospital | Peng Y.-L.,University of Sichuan | Tong X.,University of Sichuan | And 2 more authors.
Chinese Journal of Evidence-Based Medicine | Year: 2015

Objective To analyze the status of systematic reviews/meta-analyses on tuberculosis. Methods The Web of Science was searched for systematic reviews/meta-analyses on tuberculosis up to February 4th, 2015. According to the inclusion and exclusion criteria, two reviewers screened literature and extracted data. Then SPSS 11.0 software was used to analysis data including publication year, country, and institution, journal and citation situation. Results A total of 461 systematic reviews/meta-analyses were included. The publication numbers was increasing from 1 in 1997 to 82 in 2014. Among them, China ranked the top country (113 studies), followed by the USA and Canada. The area with the most number of countries where studies were published was Europe, followed by Asia and Africa. In terms of institution, McGill University in Canada ranked the top, followed by University of London in England and Sichuan University in China. As for the number of papers in journals, the International Journal of Tuberculosis and Lung Disease ranked the top, followed by PLOS One and European Respiratory Journal. In the terms of citation, the citation ranged from 0 to 591, and the median citation frequency was 8. Conclusion The systematic reviews/meta-analyses on tuberculosis is gradually increasing; the developed countries are still important output areas; and China is playing more and more important role in this research field. © 2015 Editorial Board of Chin J Evid-based Med.

Li W.,Southwest Jiaotong University | Shi L.,Southwest Jiaotong University | Deng H.,Chengdu Second Peoples Hospital | Zhou Z.,Southwest Jiaotong University
Tribology Letters | Year: 2014

In the process of surgery, operation equipments or materials inevitably rub against the internal organs or tissues of patient, which often causes a series of frictional trauma problems. However, research work on the tribological factors at the interface and subsequent friction trauma is still very limited. In this paper, the friction trauma mechanism of small intestine caused by the surgeon's fingers in the process of grasping and pulling operation was investigated in vivo by means of reciprocal sliding friction testing. The rabbit small intestine was used to simulate human small intestine. An UMT-II tribometer was used to measure tribological parameters of the rabbit small intestine under different normal force of 1.0, 2.0 and 3.0 N to simulate the grip strength of surgeon's hands. Histological analysis was used to evaluate the degree of tissue damage. Results showed that the ratio of tangential force to normal force of rabbit small intestine decreased with the normal force increasing. The frictional behavior under the three normal forces was all in the tissue damage range of intermediate regime from sticking to relative sliding. With the normal force and friction time increasing, the total friction energy dissipation on the small intestine increased, which induced the damage degree of the small intestine aggravation. The damage of rabbit small intestine extended gradually from outside to inside: serosa layer tearing and falling, muscularis bleeding, longitudinal muscularis and circular muscularis division and mucosal bleeding and necrosis. © 2014 Springer Science+Business Media New York.

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