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Duan B.-W.,Capital Medical University | Lu S.-C.,Chinese PLA General Hospital | Lai W.,Chengdu First Peoples Hospital | Liu X.-E.,Peking University | Liu Y.,Capital Medical University
Human Vaccines and Immunotherapeutics | Year: 2015

To investigate the levels of hepatitis B virus total DNA (HBV DNA) and covalently closed circular (ccc) DNA in liver transplant recipients who received hepatitis B vaccination, including responders and non-responders, following liver transplantation due to hepatitis B-related diseases and to investigate the efficacy of hepatitis B immune reconstitution against HBV reinfection. Twenty responders and 34 non-responders were enrolled in the present study. The levels of HBV total DNA and ccc DNA in peripheral blood mononuclear cells (PBMCs) and the liver and plasma were detected by real-time polymerase chain reaction (PCR). Fifty-three blood samples and 38 liver allograft tissues were acquired. For the responders, the mean serum titer for anti-HBs (antibodies against hepatitis B surface antigen) was 289 (46.64-1000) IU/ml. Also for the responders, HBV total DNA was detected in PBMCs for one recipient and in the liver for another recipient, but ccc DNA was not detected in either of those 2 recipients. For the non-responders, HBV total DNA was detected in PBMCS for 2 recipients, neither of whom had ccc DNA. Also for the non-responders, HBV total DNA was detected in the livers of 3 recipients, 2 of whom also had ccc DNA. All responders had discontinued hepatitis B immunoglobulin (HBIG), and 13 responders had discontinued antiviral agents. One responder experienced HBV recurrence during the follow-up period. For the majority of liver transplant recipients, no HBV total DNA or ccc DNA was detected in the blood or liver. The lack of HBV total DNA and ccc DNA both in PBMCs and the liver in liver transplant recipients who received hepatitis B vaccination to prevent HBV reinfection should be a prerequisite for the withdrawal of HBIG and/or antiviral agents. © 2015 Taylor & Francis Group, LLC. Source


Shi X.,University of Sichuan | Li H.,Chengdu First Peoples Hospital | Zhou Z.,University of Sichuan | Shen B.,University of Sichuan | And 2 more authors.
Journal of Arthroplasty | Year: 2016

Background: Lateral bowing of the femur, commonly observed among Asian populations, may cause malalignment after primary total knee arthroplasty (TKA). Therefore, in this study, a fixed valgus correction angle (VCA) technique for TKA was compared with individual VCA to determine which surgical technique leads to better limb and component alignment. Methods: Patients with primary TKAs with lateral bowing femurs (n = 133) were randomized to 2 groups: individual VCA (group A) and fixed VCA (group B). Full-length standing hip-knee-ankle radiographs were used to measure the VCA and limb alignment. The postoperative mechanical axis, femoral component, and tibial component alignment were measured and compared between the 2 groups. Results: The mean postoperative mechanical axis and femoral component alignment were 178.1° and 88.3°, respectively, in group A, compared with 175.9° and 86.4°, respectively, in group B (P < .05). There were 52 (77.6%) knees with ±3° mechanical axis deviation from the neutral axis in group A, compared with 19 (28.8%) in group B (P < .001). There were 56 (83.6%) knees with femoral component alignment deviation within ±3° in group A, compared with 26 (39.4%) in group B (P < 001). Conclusion: The individual VCA achieves a better radiographic limb and femoral component alignment than fixed VCA in our study patients. Preoperative hip-knee-ankle radiographs are imperative for distinguishing a bowing femur and performing accurate planning of the distal femoral resection. © 2016 Elsevier Inc. Source


Xiao S.-M.,Sichuan Cancer Hospital | Gao X.-J.,Chengdu First Peoples Hospital | Zhao P.,Sichuan Cancer Hospital
Saudi Medical Journal | Year: 2014

Methods: This meta-analysis was conducted between April and July 2013 in Sichuan Cancer Hospital, Chengdu, China. We searched PubMed, EMBASE and China Knowledge Resource Integrated Database updated until May 2013. Eight retrospective studies and one prospective study involving 2,046 total patients were included.Results: The results showed that TLDG was associated with lower blood loss (mean difference=-22.39, p=0.04). and a greater number of harvested lymph nodes (mean diference=2.74, p=0.02). There was no signifcant diference between the 2 groups in operation time, time to frst fatus, length of postoperative hospital stay, and postoperative complications.Conclusion: Compared with laparoscopy-assisted distal gastrectomy, TLDG resulted in reduced blood loss, and a greater number of harvested lymph nodes. Total laparoscopy distal gastrectomy is safe and feasible for gastric cancer.Objectives: To assess the safety and feasibility of total laparoscopy distal gastrectomy (TLDG). © 2014 Saudi Arabian Armed Forces Hospital. All rights reserved. Source


Cao W.,University of Electronic Science and Technology of China | Luo C.,University of Electronic Science and Technology of China | Zhu B.,University of Electronic Science and Technology of China | Zhang D.,University of Electronic Science and Technology of China | And 9 more authors.
Frontiers in Aging Neuroscience | Year: 2014

Growing evidence suggests that normal aging is associated with cognitive decline and well-maintained emotional well-being. The anterior cingulate cortex (ACC) is an important brain region involved in emotional and cognitive processing. We investigated resting-state functional connectivity (FC) of two ACC subregions in 30 healthy older adults vs. 33 healthy younger adults, by parcellating into rostral (rACC) and dorsal (dACC) ACC based on clustering of FC profiles. Compared with younger adults, older adults demonstrated greater connection between rACC and anterior insula, suggesting that older adults recruit more proximal dACC brain regions connected with insula to maintain a salient response. Older adults also demonstrated increased FC between rACC and superior temporal gyrus and inferior frontal gyrus, decreased integration between rACC and default mode, and decreased dACC-hippocampal and dACC-thalamic connectivity. These altered FCs reflected rACC and dACC reorganization, and might be related to well emotion regulation and cognitive decline in older adults. Our findings provide further insight into potential functional substrates of emotional and cognitive alterations in the aging brain. © 2014 Cao, Luo, Zhu, Zhang, Dong, Gong, Gong, He, Tu, Yin, Li, Chen and Yao. Source


Yan F.,University of Sichuan | Tian L.,University of Sichuan | Xiao Z.,Chengdu First Peoples Hospital | Li S.,University of Sichuan | And 2 more authors.
Clinical Lipidology | Year: 2014

Aim: To compare the effects of fenofibrate and acipimox on lipoprotein subclasses distribution in the Chinese population with Type 2 diabetes mellitus (T2DM) and hypertriglyceridemia. Patients & methods: Sixty-six patients were recruited for the 2-month study, and were divided randomly into a micronized fenofibrate group (160 mg/day; n = 33) and an acipimox group (500 mg/day; n = 33), respectively. HDL subclasses were measured by 2D gradient gel electrophoresis coupled with immunoblotting; LDL subclasses were measured by 1D gradient gel electrophoresis. Results: Compared with baseline, both fenofibrate and acipimox increased HDL2b, whereas HDL3a, small, dense LDL and oxidized LDL decreased significantly. Lipoprotein(a) significantly decreased in acipimox but not the fenfibrate group. No difference was found between these two groups on the changes of lipoprotein subclasses. Conclusion: Fenofibrate and acipimox therapy were comparably effective in modifying atherogenic lipids profile, and contributed to metabolism of HDL subclasses maturation in the Chinese population with T2DM and hypertriglyceridemia. Meanwhile, the acipimox intensively decreased lipoprotein(a) levels. © 2014 Future Medicine Ltd. Source

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