Lu Q.,Chengdong Branch |
Huang Y.,Chengdong Branch |
Kong L.-Y.,Chengdong Branch
Chinese Journal of Tissue Engineering Research | Year: 2014
BACKGROUND: Tissue patch is used to increase bone mass after mandibular molar extraction, which is conducive to late-stage repair, but it is unexpectedly found that after implantation of tissue patch, incidence of dry socket is significantly reduced. OBJECTIVE: To assess the efficacy of tissue patch for the control of dry socket caused by mandibular molar extraction via the method of systematic review. METHODS: MEDLINE (OVID), CENTRAL, EMBASE and CBM were searched for clinical randomized controlled trials and clinical controlled trials. The keywords were “dry socket, tissue patch, acellular dermis matrix, tooth extraction” in English and Chinese. The references of the included studies and 19 Chinese dental journals were hand-searched. Two reviewers independently assessed the risk of bias using Cochrane Collaboration’s tool, and extracted data. Meta-analysis was delivered with Revman 5.1. RESULTS AND CONCLUSION: Eight studies, including five randomized controlled trials and three clinical controlled trials, were included. Totally 2 052 participants were involved. Seven of the included studies had moderate risk of bias and one had high risk of bias. Meta analysis showed that implantation of the tissue patch into the extraction socket could reduce 86% of the risk of dry socket (relative risk=0.14, 95% confidence interval [0.08, 0.26], P < 0.000 01). Sensitivity analysis showed that this outcome was relatively stable. Implantation of tissue patch into extraction socket could significantly reduce the risk of dry socket, but more randomized controlled trials are needed. © 2014, Journal of Clinical Rehabilitative Tissue Engineering Research. All Rights Reserved.