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Liao C.-C.,Cheng Ching Hospital | Liao C.-C.,Chung Shan Medical University | Ou T.-T.,Chung Shan Medical University | Wu C.-H.,China Medical University at Taichung | Wang C.-J.,Chung Shan Medical University
Journal of Agricultural and Food Chemistry | Year: 2013

This study investigated the influence of phenolic caffeic acid on obesity in mice fed a high fat diet and its underlying mechanisms base on adipose and hepatic lipid lipogenesis. C57BL/6 mice were fed a normal diet or a HFD (20% fat, w/w) with or without caffeic acid (0.02% and 0.08%, w/w) for 6 weeks. The effects of caffeic acid on hyperlipidemia, hyperglycemia, visceral fat accumulation, and related enzyme activities in HFD-mice are examined. The supplementation of caffeic acid significantly lowered body weight, visceral fat mass, plasma GOT and GPT levels, FAS activity, and free fatty acid compared to the HFD group. Caffeic acid also lowered triglyceride and cholesterol concentrations in plasma and liver. Furthermore, we showed that caffeic acid efficiently inhibited cholesterol biosynthesis as evidenced by 3-hydroxy-3-methylglutaryl CoA reductase in the liver. Caffeic acid supplementation suppressed the activity of lipogenesis via sterol regulatory element-binding protein 1 c and its target enzyme fatty acid synthase. In addition, caffeic acid resulted in increased phosphorylation of AMP-activated protein kinase and decreased acetyl carboxylase, a downstream target of AMPK, which are related to fatty acid β-oxidation in the liver. In conclusion, these results indicate that caffeic acid exhibits a significant potential as an antiobesity agent by suppression of lipogenic enzymes and hepatic lipid accumulation. © 2013 American Chemical Society. Source


Liao C.-C.,Cheng Ching Hospital | Liao C.-C.,Chung Shan Medical University | Ou T.-T.,Chung Shan Medical University | Huang H.-P.,Chung Shan Medical University | Wang C.-J.,Chung Shan Medical University
Journal of the Science of Food and Agriculture | Year: 2014

BACKGROUND: Caffeic acid (CA) can inhibit toxin-induced liver injury. In this study, CA is assessed for its lipid lowering potential when oleic acid is used to induce non-alcoholic fatty liver disease in human HepG2 cells. RESULTS: The results showed that both the triglyceride and cholesterol content are decreased in the HepG2 cells by using the enzymatic colorimetric method. CA enhances the phosphorylation of AMP-activated protein kinase (AMPK) and its primary downstream targeting enzyme, acetyl-CoA carboxylase. CA down-regulates the lipogenesis gene expression of sterol regulatory element-binding protein-1 and its target genes, fatty acid synthase in the presence of oleic acid. In addition, CA significantly decreases cholesterol and triglyceride production via inhibition the expression of both 3-hydroxy-3-methyglutary coenzyme A reductase and glycerol-3-phosphate acyltransferase. These effects are eliminated by pretreatment with compound C, an AMPK inhibitor. CONCLUSIONS: These results demonstrate that CA inhibits oleic acid induced hepatic lipogenesis and the promotion of lipolysis via up-regulation of AMP-activated kinase. © 2013 Society of Chemical Industry. Source


Hsieh Y.-L.,Graduate Institute of Rehabilitation Science | Chou L.-W.,Graduate Institute of Rehabilitation Science | Chou L.-W.,China Medical University at Taichung | Joe Y.-S.,Cheng Ching Hospital | And 2 more authors.
Archives of Physical Medicine and Rehabilitation | Year: 2011

Hsieh Y-L, Chou L-W, Joe Y-S, Hong C-Z. Spinal cord mechanism involving the remote effects of dry needling on the irritability of myofascial trigger spots in rabbit skeletal muscle. Objective: To elucidate the neural mechanisms underlying the remote effects produced by dry needling rabbit skeletal muscle myofascial trigger spots (MTrSs) via analyses of their endplate noise (EPN) recordings. Design: Experimental animal controlled trial. Setting: An animal laboratory of a university. Animals: Male New Zealand rabbits (N=96) (body weight, 2.53.0kg; age, 1620wk). Intervention: Animals received no intervention for neural interruption in group I, transection of the tibial nerve in group II, transection of L5 and L6 spinal cord in group III, and transection of the T1 and T2 spinal cord in group IV. Each group was further divided into 4 subgroups: animals received ipsilateral dry needling, contralateral dry needling, ipsilateral sham needling, or contralateral sham needling of gastrocnemius MTrSs. Main Outcome Measures: EPN amplitudes of biceps femoris (BF) MTrSs. Results: BF MTrS mean EPN amplitudes significantly increased (P<.05) initially after gastrocnemius verum needling but reduced to a level significantly lower (P<.05) than the preneedling level in groups I and IV with ipsilateral dry needling or contralateral dry needling, and in group II with contralateral dry needling (but not ipsilateral dry needling). No significant EPN amplitude changes were observed in BF MTrS in group III or in the control animals receiving superficial needling (sham). Conclusion: This remote effect of dry needling depends on an intact afferent pathway from the stimulating site to the spinal cord and a normal spinal cord function at the levels corresponding to the innervation of the proximally affected muscle. © 2011 American Congress of Rehabilitation Medicine. Source


Hsieh L.-P.,Cheng Ching Hospital | Hsieh L.-P.,Tunghai University | Hsieh L.-P.,Sudan University of Science and Technology | Huang C.-Y.,Tunghai University
Epilepsy Research | Year: 2011

Purpose: The aim of this study was to evaluate the prevalence of prescription and use of antiepileptic drugs (AEDs) for the treatment of epilepsy and other indications in a nationwide population using a prescription database. Materials and methods: AED prescription data were collected from the National Health Insurance Research Database (NHIRD) in Taiwan for a 5-year period (2003-2007). Patients prescribed AEDs at least two times from 2003 to 2007 were selected for the study from a random sample that included approximately 600,000 people. Results: The prevalence of AED use (per 1000 inhabitants) increased from 12.6 in 2003 to 13.8 in 2007. The prevalence of newer AED use increased progressively from 1.0 in 2003 to 3.8 in 2007, but the prevalence of older AED use decreased during this time (11.6-10). Carbamazepine and valproic acid were the most common AEDs used. Among the newer generation of AEDs, gabapentin was the most frequently used. Newer AEDs were used primarily to treat pain disorders. The primary class of drugs used to treat epileptic disorders was older AEDs. Conclusion: An increase in the use of AEDs was observed over a 5-year period in data collected from NHIRD. This might implicate the use of newer compounds at clinical practice not only increased in the treatment of epilepsy, but also in the conditions other than epilepsy especially pain disorders. © 2011 Elsevier B.V. Source


Tsai C.-H.,Cheng Ching Hospital | Tsai C.-H.,Chaoyang University of Technology | Tsai C.-H.,Hungkuang University
BMC Health Services Research | Year: 2010

Background. Studies of outpatient department patients indicate that somatic discomforts such as headache, neck pain, chest pain, low back pain, and gastrointestinal discomfort are commonly found in patients with multiple complaints. Clustering of some symptoms has been found in common somatic symptom analyses. Because of the complexity involved in the diagnosis of patients with multiple complaints, the aim of this study is to identify and classify patterns of somatic symptoms in individuals assessed during a health examination. Methods. A total of 683 patients (437 males, 246 females) received a one-day physical examination and completed a structured survey during the period from May 2007 to April 2008. A physical symptoms interview was conducted, and medical and demographic data was collected. Results. Based on the factor analysis, 4 clusters of symptoms were identified: 1) pain symptoms, 2) cold symptoms, 3) cardiopulmonary symptoms, and 4) gastrointestinal symptoms. The distribution of symptoms differed between males and females. After varimax rotation of factor patterns, 4 extracted factors emerged. In males, the factors were 1) pain symptoms, 2) cold symptoms, 3) cardiopulmonary symptoms, and 4) gastrointestinal symptoms. In females, the factors were 1) pain symptoms, 2) cold symptoms, 3) cardiopulmonary symptoms, and 4) head and gastrointestinal symptoms. Conclusions. Four clusters of somatic symptoms emerged for both males and females; however, the predominant symptoms were different in males and females. Females displayed more head-related symptoms than males. Patients should be thoroughly interviewed about additional symptoms within the same cluster after the recognition of a single somatic complaint. © 2010 Tsai; licensee BioMed Central Ltd. Source

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