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Agency: European Commission | Branch: H2020 | Program: RIA | Phase: NMP-08-2014 | Award Amount: 6.28M | Year: 2015

The aim of NanoPilot will be to set-up a flexible and adaptable pilot plant operating under GMP for the production of small batches of polymer-based nanopharmaceuticals, which exhibit significant potential in the field of drug-delivery particularly for the design of second-generation nanopharmaceuticals. Three different processes will be established for the production of three different nanopharmaceuticals selected on the basis of their TRL and positive commercial evaluation: a) topical treatment of ocular pain associated with dry eye syndrome containing short interfering RNA and lactic acid, b) A resuspendable HIV nanovaccine for intranasal vaccination containing 12 peptides in its formulation. c) Hyaluronan based hollow spheres intended for intravesical instillation, for the treatment of interstitial cystitis/painful bladder syndrome. State of the art production processes including micro reactors and highly advanced characterization techniques will ensure the quality of the nanodrugs. Existing laboratories suitable for large-scale production of biologics in compliance with GMP, and owned by the coordinator, will be adapted and certified within this project to enable the operability of the pilot plant. NanoPilot consists of nine complementary partners composed by 1 Industry and 2 academia developers of the nanosystems to scale-up. A research Institute expert in nanoparticle characterizacion and already operating in compliance with Good laboratory practices. An SME and an Industry that will develop ad-hoc continuous flow reactors for the optimization of two of the three processes. A consultancy (SME) expert in Quality system implementation and laboratory information management systems. A second consultancy (SME) in charge of the business plan, that will also help the coordinator in dissemination and exploitation activities. Finally, a research centre with a recorded track in nanomedicine, already operating under ISO 9001, and will be in charge of the pilot plant.


News Article | February 24, 2017
Site: marketersmedia.com

— In the reporting year, the sales Revenue of Micro Bioreactors increases from 177.51 M USD in 2012 to 256.84 M USD in 2016, with a CAGR of more than 9.68%. In the Europe, the region contributing the highest share of sales revenue of slightly more than 26% in 2016, despite stagnant macroeconomic environment in this region in the reporting year. The Emerging developing countries represented by China has Witnessed high rates increase in the reporting year, the sales revenue of China increases from 20.11 M USD in 2012 to 37.53 M USD in 2016, with an CAGR of more than 16.88%. However, high cost of instruments, lack of research and development of technology especially in emerging economies, and lack of laboratory technicians are expected to restrain the growth of this market. The Global Micro Bioreactors Market Research Report 2017 is a professional and in-depth study on the current state of the Micro Bioreactors industry. In a word, This report studies Micro Bioreactors in Global market, especially in North America, China, Europe, Japan, Southeast Asia and India, focuses on top manufacturers in global market, with capacity, production, price, revenue and market share for each manufacturer. Key companies included in this research are Pall Corporation , Sartorius, Eppendorf, M2p-labs, Applikon Biotechnology, Chemtrix, CerCell, INFORS HT, LAVAL LAB and PBS Biotech. Market Segment by Region, this report splits Global into several key Region, with sales, revenue, market share and growth rate of Micro Bioreactors in these regions, from 2011 to 2022 (forecast), like United States, North America, China, Europe, Japan, Southeast Asia and India. Firstly, Micro Bioreactors Market Split by Product Types, with production, revenue, price, market share and growth rate of each type, can be divided into 24 Parallel Bioreactors, 48 Parallel Bioreactors and Others. Split by applications, this report focuses on consumption, market share and growth rate of Micro Bioreactors in each application, can be divided into Pharma, Biotech, Food Industry, Scientific Research Institutes and Others. 7.1 Pall Corporation 48 7.1.1 Company Basic Information, Manufacturing Base, Sales Area and Its Competitors 48 7.1.2 Micro Bioreactors Product Types, Application and Specification 49 7.1.3 Pall Corporation Micro Bioreactors Production, Revenue, Gross and Price (2015 and 2016) 51 7.1.4 Main Business/Business Overview 51 7.2 Sartorius 52 7.2.1 Company Basic Information, Manufacturing Base, Sales Area and Its Competitors 52 7.2.2 Micro Bioreactors Product Types, Application and Specification 53 7.2.3 Sartorius Micro Bioreactors Production, Revenue, Gross and Price (2015 and 2016) 54 7.2.4 Main Business/Business Overview 55 7.3 Eppendorf 55 7.3.1 Company Basic Information, Manufacturing Base, Sales Area and Its Competitors 55 7.3.2 Micro Bioreactors Product Types, Application and Specification 56 7.3.3 Eppendorf Micro Bioreactors Production, Revenue, Gross and Price (2015 and 2016) 57 7.3.4 Main Business/Business Overview 58 Table Europe Micro Bioreactors Production, Revenue, Price and Gross Margin (2012-2017E) 33 Table China Micro Bioreactors Production, Revenue, Price and Gross Margin (2012-2017E) 33 Table Japan Micro Bioreactors Production, Revenue, Price and Gross Margin (2012-2017E) 34 Table Southeast Asia Micro Bioreactors Production, Revenue, Price and Gross Margin (2012-2017E) 34 Table India Micro Bioreactors Production, Revenue, Price and Gross Margin (2012-2017E) 35 Table Global Micro Bioreactors Consumption (Unit) Market by Regions (2012-2017E) 36 Table Global Micro Bioreactors Consumption Market Share by Regions (2012-2017E) 36 Figure Global Micro Bioreactors Consumption Market Share by Regions (2012-2017E) 37 Figure 2015 Global Micro Bioreactors Consumption Market Share by Regions 37 Table USA Micro Bioreactors Production, Consumption, Import & Export (2012-2017E) 38 Table Europe Micro Bioreactors Production, Consumption, Import & Export (2012-2017E) 38 Table China Micro Bioreactors Production, Consumption, Import & Export (2012-2017E) 38 Table Japan Micro Bioreactors Production, Consumption, Import & Export (2012-2017E) 39 Table Southeast Asia Micro Bioreactors Production, Consumption, Import & Export (2012-2017E) 39 Table India Micro Bioreactors Production, Consumption, Import & Export (2012-2017E) 39 Table Global Micro Bioreactors Production (Unit) by Types (2012-2017E) 40 Table Global Micro Bioreactors Production Share by Types (2012-2017E) 40 Figure Production Market Share of Micro Bioreactors by Types (2012-2017E) 41 Figure 2016 Production Market Share of Micro Bioreactors by Types 41 Table Global Micro Bioreactors Revenue (M USD) by Types (2012-2017E) 42 Table Global Micro Bioreactors Revenue Share by Types (2012-2017E) 42 Figure Production Revenue Share of Micro Bioreactors by Types (2012-2017E) 42 Figure 2016 Revenue Market Share of Micro Bioreactors by Types 43 Table Global Micro Bioreactors Price (K USD/Units) by Types (2012-2017E) 43 Figure Global Micro Bioreactors Production Growth by Type (2012-2017E) 44 Table Global Micro Bioreactors Consumption (Unit) by Applications (2012-2017E) 45 Table Global Micro Bioreactors Consumption Market Share by Applications (2012-2017E) 45 Figure Global Micro Bioreactors Consumption Market Share by Applications in 2015 46 Table Global Micro Bioreactors Consumption Growth Rate by Applications (2012-2017E) 46 For more information, please visit http://www.reportsweb.com/global-micro-bioreactors-market-2017


News Article | February 28, 2017
Site: marketersmedia.com

In the reporting year, the sales Revenue of Micro Bioreactors increases from 177.51 M USD in 2012 to 256.84 M USD in 2016, with a CAGR of more than 9.68%. In the Europe, the region contributing the highest share of sales revenue of slightly more than 26% in 2016, despite stagnant macroeconomic environment in this region in the reporting year. The Emerging developing countries represented by China has Witnessed high rates increase in the reporting year, the sales revenue of China increases from 20.11 M USD in 2012 to 37.53 M USD in 2016, with an CAGR of more than 16.88%. However, high cost of instruments, lack of research and development of technology especially in emerging economies, and lack of laboratory technicians are expected to restrain the growth of this market. This report studies Micro Bioreactors in Global market, especially in North America, Europe, China, Japan, Southeast Asia and India, focuses on top manufacturers in global market, with production, price, revenue and market share for each manufacturer, covering Market Segment by Regions, this report splits Global into several key Regions, with production, consumption, revenue, market share and growth rate of Micro Bioreactors in these regions, from 2011 to 2021 (forecast), like Split by Product Types, with production, revenue, price, market share and growth rate of each type, can be divided into 24 Parallel Bioreactors 48 Parallel Bioreactors Others Split by applications, this report focuses on consumption, market share and growth rate of Micro Bioreactors in each application, can be divided into Pharma Biotech Food Industry Scientific Research Institutes Others 1 Micro Bioreactors Market Overview 1 1.1 Product Overview and Scope of Micro Bioreactors 1 1.2 Micro Bioreactors Segment by Types 2 1.2.1 Global Revenue Market Share of Micro Bioreactors by Types in 2015 2 1.2.2 24 Parallel Bioreactors 3 1.2.3 48 Parallel Bioreactors 4 1.2.4 Others 5 1.3 Micro Bioreactors Segment by Applications 6 1.3.1 Micro Bioreactors Revenue Market Share by Applications in 2015 6 1.3.2 Pharma 7 1.3.3 Biotech 7 1.3.4 Food Industry 7 1.3.5 Scientific Research Institutes 8 1.3.6 Others 9 1.4 Micro Bioreactors Market by Regions 9 1.4.1 USA Status and Prospect (2017-2022) 9 1.4.2 Europe Status and Prospect (2017-2022) 10 1.4.3 China Status and Prospect (2017-2022) 11 1.4.4 Japan Status and Prospect (2017-2022) 12 1.4.5 Southeast Asia Status and Prospect (2017-2022) 13 1.4.6 India Status and Prospect (2017-2022) 14 1.5 Global Market Size (Value) of Micro Bioreactors (2017-2022) 15 7 Global Micro Bioreactors Manufacturers Profiles/Analysis 48 7.1 Pall Corporation 48 7.1.1 Company Basic Information, Manufacturing Base, Sales Area and Its Competitors 48 7.1.2 Micro Bioreactors Product Types, Application and Specification 49 7.1.3 Pall Corporation Micro Bioreactors Production, Revenue, Gross and Price (2015 and 2016) 51 7.1.4 Main Business/Business Overview 51 7.2 Sartorius 52 7.2.1 Company Basic Information, Manufacturing Base, Sales Area and Its Competitors 52 7.2.2 Micro Bioreactors Product Types, Application and Specification 53 7.2.3 Sartorius Micro Bioreactors Production, Revenue, Gross and Price (2015 and 2016) 54 7.2.4 Main Business/Business Overview 55 7.3 Eppendorf 55 7.3.1 Company Basic Information, Manufacturing Base, Sales Area and Its Competitors 55 7.3.2 Micro Bioreactors Product Types, Application and Specification 56 7.3.3 Eppendorf Micro Bioreactors Production, Revenue, Gross and Price (2015 and 2016) 57 7.3.4 Main Business/Business Overview 58 7.4 M2p-labs 59 7.4.1 Company Basic Information, Manufacturing Base, Sales Area and Its Competitors 59 7.4.2 Micro Bioreactors Product Types, Application and Specification 59 7.4.3 M2p-labs Micro Bioreactors Production, Revenue, Gross and Price (2015 and 2016) 60 7.4.4 Main Business/Business Overview 61 7.5 Applikon Biotechnology 62 7.5.1 Company Basic Information, Manufacturing Base, Sales Area and Its Competitors 62 7.5.2 Micro Bioreactors Product Types, Application and Specification 63 7.5.3 Applikon Biotechnology Micro Bioreactors Production, Revenue, Gross and Price (2015 and 2016) 64 7.5.4 Main Business/Business Overview 65 7.6 Chemtrix 65 7.6.1 Company Basic Information, Manufacturing Base, Sales Area and Its Competitors 65 7.6.2 Micro Bioreactors Product Types, Application and Specification 66 7.6.3 Chemtrix Micro Bioreactors Production, Revenue, Gross and Price (2015 and 2016) 67 7.6.4 Main Business/Business Overview 68 7.7 CerCell 69 7.7.1 Company Basic Information, Manufacturing Base, Sales Area and Its Competitors 69 7.7.2 Micro Bioreactors Product Types, Application and Specification 69 7.7.3 CerCell Micro Bioreactors Production, Revenue, Gross and Price (2015 and 2016) 70 7.7.4 Main Business/Business Overview 71 7.8 INFORS HT 72 7.8.1 Company Basic Information, Manufacturing Base, Sales Area and Its Competitors 72 7.8.2 Micro Bioreactors Product Types, Application and Specification 72 7.8.3 INFORS HT Micro Bioreactors Production, Revenue, Gross and Price (2015 and 2016) 74 7.8.4 Main Business/Business Overview 74 7.9 LAVAL LAB 75 7.9.1 Company Basic Information, Manufacturing Base, Sales Area and Its Competitors 75 7.9.2 Micro Bioreactors Product Types, Application and Specification 76 7.9.3 LAVAL LAB Micro Bioreactors Production, Revenue, Gross and Price (2015 and 2016) 77 7.9.4 Main Business/Business Overview 78 7.10 PBS Biotech 78 7.10.1 Company Basic Information, Manufacturing Base, Sales Area and Its Competitors 78 7.10.2 Micro Bioreactors Product Types, Application and Specification 79 7.10.3 PBS Biotech Micro Bioreactors Production, Revenue, Gross and Price (2015 and 2016) 80 7.10.4 Main Business/Business Overview 81 For more information, please visit https://www.wiseguyreports.com/sample-request/996004-global-micro-bioreactors-market-2017


Wiles C.,Chemtrix BV | Watts P.,University of Hull
Beilstein Journal of Organic Chemistry | Year: 2011

Whilst microwave heating has been widely demonstrated as a synthetically useful tool for rapid reaction screening, a microwaveabsorbing solvent is often required in order to achieve efficient reactant heating. In comparison, microreactors can be readily heated and pressurised in order to "super-heat" the reaction mixture, meaning that microwave-transparent solvents can also be employed. To demonstrate the advantages associated with microreaction technology a series of S NAr reactions were performed under continuous flow by following previously developed microwave protocols as a starting point for the investigation. By this approach, an automated microreaction platform (Labtrix® S1) was employed for the continuous flow synthesis of diaryl ethers at 195 °C and 25 bar, affording a reduction in reaction time from tens of minutes to 60 s when compared with a stopped-flow microwave reactor. © 2011 Verma et al; licensee Beilstein-Institut.


Wiles C.,Chemtrix BV | Watts P.,University of Hull
ChemSusChem | Year: 2012

In light of the growing interest in the use of rare earth metal triflates as water-tolerant Lewis acid catalysts, we embarked upon the development of a solid-supported gallium triflate (PS-Ga(OTf) 2) derivative as a means of increasing the cleanliness and cost effectiveness of using these increasingly expensive catalytic materials in synthetic processes. Having previously highlighted the advantages associated with coupling solid-supported catalysis and the emerging area of micro-reaction technology, we screened PS-Ga(OTf) 2 for activity towards the ketonic Strecker reaction, in which the target α-aminonitriles were obtained in higher yield and purity compared to reactions reported in literature, in which the analogous homogeneous catalyst was used. Trifle gallium supporters: A solid supported gallium triflate derivative is synthesized and screened for activity towards the ketonic Strecker reaction. The target α-aminonitriles are obtained in higher yield and purity compared to reactions reported in literature, for which the analogous homogeneous catalyst is used. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.


Wiles C.,Chemtrix BV | Watts P.,Chemtrix BV | Watts P.,University of Hull
Chemical Communications | Year: 2011

It is the intention of this review to provide the reader with a survey of the current literature pertaining to the use of micro reactors in synthetic chemistry; recent advances are briefly discussed, with references provided to assist with further reading on this rapidly growing research topic. © 2011 The Royal Society of Chemistry.


Wiles C.,Chemtrix BV | Watts P.,University of Hull
Green Chemistry | Year: 2012

With aspects of continuous processing featuring heavily in efforts towards increasing the 'green' prospects of pharmaceutical and fine chemical manufacturing, this article focuses on the developments made into the application of continuous flow reactors for sustainable chemical research and production. © 2012 The Royal Society of Chemistry.


Patent
Chemtrix B.V. | Date: 2010-11-17

The present invention relates to a micro-fluidic system comprising:a. a planar micro-fluidic device comprising a plurality of inlets and at least one outlet;b. a holder comprising a first part being provided with a plurality of channels having first ends and second ends, the holder comprising a fixing means for clamping the micro-fluidic device;c. sealing means being arranged to connect the plurality of inlets and the at least one out-let of the micro-fluidic device to the second ends of the plurality of channels;characterized in that the sealing means are arranged such that a surface contact between the micro-fluidic device and the sealing means and a surface contact between the sealing means and the first part of the holder is established. The present invention also relates to the use of such a micro-fluidic systems at high pressures and high temperatures.


Patent
Chemtrix B.V. | Date: 2011-08-24

The present invention relates to a micro-fluidic device comprising a process channel having a top wall, a bottom wall and side walls, the process channel having a height between 0.2 mm and 3 mm, a width between 1.0 and 50 mm and support means within said process channel. The support means extends between the bottom wall and the top wall of the process channel in a direction substantially perpendicularly to the top wall. The micro-fluidic device comprises at least one heat exchange means parallel to the process channel and optionally comprises a static mixing element. The present invention further relates to a kit of parts and a micro-fluidic system comprising such micro-fluidic devices.


Patent
Chemtrix B.V. | Date: 2013-08-14

The invention relates to a micro-fluidic system comprising a first element of a first material comprising a channel comprising at least one inlet and at least one outlet for transporting fluids, wherein the channel has at least one cross-sectional dimension in the range from 0.05 to 10mm and a second element of a second material in communication with the channel and which is contacted by the fluid materials during operation of the micro-fluidic system, wherein the second material comprises a reinforced polytetrafluoroethylene.

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