Mountain View Acres, CA, United States
Mountain View Acres, CA, United States

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Patent
ChemoCentryx Inc. | Date: 2016-11-17

Compounds are provided that are modulators of the C5a receptor. The compounds are substituted piperidines and are useful in pharmaceutical compositions, methods for the treatment of diseases and disorders involving the pathologic activtation of C5a receptors.


Patent
ChemoCentryx Inc. | Date: 2016-12-19

Compounds are provided that act as potent antagonists of the CCR2 receptor. Animal testing demonstrates that these compounds are useful for treating inflammation, a hallmark disease for CCR2. The compounds are generally aryl sulfonamide derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR2-mediated diseases, and as controls in assays for the identification of CCR2 antagonists.


Patent
ChemoCentryx Inc. | Date: 2017-01-06

Compounds are provided that are modulators of the C5a receptor. The compounds are substituted piperidines and are useful in pharmaceutical compositions, methods for the treatment of diseases and disorders involving the pathologic activation of C5a receptors.


Patent
ChemoCentryx Inc. | Date: 2016-03-18

Compounds of formula (I) are provided which are useful in the treatment of diseases or conditions modulated at least in part by CCR6:


Patent
ChemoCentryx Inc. | Date: 2016-02-23

Compounds are provided that act as potent antagonists of the CCR1 receptor, and have in vivo anti-inflammatory activity. The compounds are generally aryl piperazine derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR1-mediated diseases, and as controls in assays for the identification of competitive CCR1 antagonists.


Patent
ChemoCentryx Inc. | Date: 2016-10-12

A process for preparing a compound of formula (ii),(a) treating a compound of formula (i) with H_(2) and a platinum oxide catalyst under reducing conditions; and(b) subjecting the product of step (a) to resolution with di-toluoyl-L-tartaric acid to provide compound (ii) in about 97% enantiomeric excess.


Patent
ChemoCentryx Inc. | Date: 2016-07-11

Aniline compounds are provided which bind to CCR(4) and are useful for the treatment of diseases such as allergic diseases, autoimmune diseases, graft rejection and cancer.


Compounds are provided that act as potent antagonists of the CCR2 receptor. The compounds are generally aryl sulfonamide derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR2-mediated diseases and as controls in assays for the identification of CCR2 antagonists.


Patent
ChemoCentryx Inc. | Date: 2016-03-18

Compounds are provided that act as potent antagonists of the CCR1 receptor, and have in vivo anti-inflammatory activity. The compounds are diazole lactam derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR1-mediated disease, and as controls in assays for the identification of competitive CCR1 antagonists.


Patent
ChemoCentryx Inc. | Date: 2016-05-19

Compounds are provided that are modulators of the CCR2 receptor. The compounds have the general formula (I): and are useful in pharmaceutical compositions, methods for the treatment of diseases and disorders involving the pathologic activtation of CCR2 receptors.

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