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Gebze Kocaeli, Turkey

Cigremis Y.,Inonu University | Ulukanli Z.,Osmaniye Korkut Ata University | Ilcim A.,Kahramanmaras Sutcu Imam University | Akgoz M.,Chemistry Group Laboratories
European Review for Medical and Pharmacological Sciences | Year: 2010

Background and Objectivies: Nepeta species are used as diuretic, diaphoretic, antitussive, antispasmodic, antiasthmatic, febrifuge, emmenagogue, sedative agents, insecticidal, acaricidal, antiviral, anti-inflammatory and antioxidant. Acetone extract of Nepeta meyeri (Labiatae) was screened for antioxidant and antimicrobial activities. Materials and Methods: The antioxidant properties of the extract were investigated by using various methods established in vitro systems such as 1,1-diphenyl-2-picrylhydrazyl (DPPH)/nitric oxide (NO) radical scavenging activity. Reducing power and total phenolic substance analysis and also antimicrobial activity of acetone extract of Nepeta meyeri were tested against six gram negative, seven gram positive bacteria and the yeast strain using the disc diffusion method. Results and Discussion: Acetone extract of the plant examined exhibited a significant concentration-dependent inhibition of DPPH and NO• radical. Furthermore, Nepeta meyeri showed very high reducing power. In DPPH radical and NO• scavenging assays the IC50 value of extract was 672.2 μg/ml and 165.32 μg/ml, respectively. The amounts of total phenolic compounds were also determined and 12.86 μg pyrocatechol equivalents of phenols were detected in the extract. The data obtained from these in vitro models clearly demonstrated antioxidant potential of acetone extract of Nepeta meyeri. The extract revealed antibacterial activity against all gram positive bacteria but not was active against gram negative bacteria. Source


Goren A.C.,Chemistry Group Laboratories | Bilsel G.,Chemistry Group Laboratories | Ozturk A.H.,Istanbul University | Topcu G.,Technical University of Istanbul
Natural Product Communications | Year: 2010

The compositions of colophony resins obtained from Pinus brutia Ten trees by three different methods (acid paste, carved hole and scraping) from Ayvacik, Gökova and Kemalpaşa in Turkey were analyzed by capillary GC-MS. The main components were the monoterpenes α-pinene, β-pinene, and Δ 3-carene, and the diterpenic resin acids palustric, abietic, kaur-9(11)-16-en-18-oic and neoabietic acid. The synthetic colophony resins exhibited similar contents to those of the natural resins obtained from the Gökova and Kemalpaşa regions of Turkey. However, colophony resins from Ayvacik exhibited only half the diterpenic acid content as those of the Gökova and Kemalpaşa resins. Out of the three techniques, the carved hole method caused rather different percentages in the constituents of the essential oils. Source


Goren A.C.,Chemistry Group Laboratories | Piozzi F.,University of Palermo | Akcicek E.,Balikesir University | Kili T.,Balikesir University | And 3 more authors.
Phytochemistry Letters | Year: 2011

The essential oils from twenty-two different Stachys species were obtained by hydrodistillation and analyzed by gas chromatography-mass spectrometry (GC-MS). Thirty-nine compounds, which accounted for 70.5-97.8% of the total composition of the oils, have been identified. Germacrene-D (2.9-45.3%), β-caryophyllene (2.3-62.3%), caryophyllene oxide (trace to 7.8%), spathulenol (trace to 7.8%) and α-cadinene (1.4-8.5%) have been identified as the main components of the essential oils. Antimicrobial assessments of the essential oils were evaluated against Escherichia coli, Staphylococcus aureus, Klebsiella pneumoniae, Pseudomonas aeruginosa and Candida albicans by disc diffusion method. Most of the essential oils showed moderate activity against the studied microorganisms. © 2011 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved. Source

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