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Mohajer S.,University of Malaya | Mat Taha R.,University of Malaya | Lay M.M.,University of Malaya | Khorasani Esmaeili A.,University of Malaya | Khalili M.,Chemistry and Chemical Engineering Research Center
Scientific World Journal | Year: 2014

Sainfoin (Onobrychis viciifolia Scop. Syn. Onobrychis sativa L.) is a bloat-safe forage crop with high levels of tannins, which is renowned for its medicinal qualities in grazing animals. Mutagenesis technique was applied to investigate the influence of gamma irradiation at 30, 60, 90, and 120 Gy on mitotic behavior, in vitro growth factors, phytochemical and nutritional constituents of sainfoin. Although a percentage of plant necrosis and non-growing seed were enhanced by irradiation increment, the germination speed was significantly decreased. It was observed that gamma irradiated seeds had higher value of crude protein and dry matter digestibility compared to control seeds. Toxicity of copper was reduced in sainfoin irradiated seeds at different doses of gamma rays. Anthocyanin content also decreased in inverse proportion to irradiation intensity. Accumulation of phenolic and flavonoid compounds was enhanced by gamma irradiation exposure in leaf cells. HPLC profiles differed in peak areas of the two important alkaloids, Berberine and Sanguinarine, in 120 Gy irradiated seeds compared to control seeds. There were positive correlations between irradiation dose and some abnormality divisions such as laggard chromosome, micronucleus, binucleated cells, chromosome bridge, and cytomixis. In reality, radiocytological evaluation was proven to be essential in deducing the effectiveness of gamma irradiation to induce somaclonal variation in sainfoin. © 2014 Sadegh Mohajer et al.

Ghassempour A.,Shahid Beheshti University | Ghahramanzamaneh M.,Shahid Beheshti University | Hashempour H.,Shahid Beheshti University | Kargosha K.,Chemistry and Chemical Engineering Research Center
Acta Chromatographica | Year: 2011

In this study, different columns, including C18, C8, and CN, were investigated for the analysis of cyclotides in Viola ignobilis. Because of the complexity of the cyclotide matrix in V. ignobilis and the presence of their different isomers, suitable separations could not be obtained by high-performance liquid chromatography (HPLC). Also, a miniaturized column with a powerful determination technique, such as nanoliquid chromatography-Fourier transform mass spectroscopy (nano-LC-FTMS), could not succeed in the identification of all the cyclotides. Thus, a multidimensional liquid chromatography (MDLC), in the heart-cutting and mixed-bed modes, has been developed to separate the cyclotides. In the heart-cutting MDLC, the C8-C18 and C8-CN conditions were investigated and a good resolution could be obtained for the isolation of a few specific peaks. In the mixed-bed mode, a C8-CN condition was investigated and good separation was obtained by a gradient condition. The results of these methods are compared.

Saeidifar M.,Iranian Materials and Energy Research Center | Mansouri-Torshizi H.,University of Sistan and Baluchestan | Palizdar Y.,Iranian Materials and Energy Research Center | Eslami-Moghaddam M.,Chemistry and Chemical Engineering Research Center | And 2 more authors.
Acta Chimica Slovenica | Year: 2014

A new anionic 8-hydroxyquinolinatopalladate(II) complex with malonate has been synthesized and characterized by elemental analysis, conductivity, FT-IR, UV-Vis and 1H NMR techniques to enhance the development of potential anticancer agents. Cytotoxicity was determined against the human leukemia cells, molt, by MTT assay. The novel antitumor Pd(II) complex was evaluated for its binding to calf thymus DNA (ctDNA) in physiological buffer (pH 7.0) by using absorption spectroscopy, fluorescence titration spectra, ethidium bromide displacement and gel chromatography studies. The results obtained from these analyses indicated that the water-soluble complex can bind to DNA cooperatively through a static quenching procedure at low concentrations. Thermodynamic parameters obtained from fluorescence experiments at different temperatures revealed the hydrogen binding and van der Waals force in the binding process which was supported by Scatchard's plots.

Saeidifar M.,Iranian Materials and Energy Research Center | Khanlarkhani A.,Iranian Materials and Energy Research Center | Eslami-Moghaddam M.,Chemistry and Chemical Engineering Research Center | Mansouri-Torshizi H.,University of Sistan and Baluchestan | Akbar Saboury A.,University of Tehran
Polycyclic Aromatic Compounds | Year: 2016

The interaction of 1, 10-phenanthroline octhyldithiocarbamato palladium(II) nitrate ([Pd(Oct-dtc)(phen)]NO3) with human serum albumin (HSA) has been investigated by various spectroscopic techniques under physiological conditions. Here, HSA was titrated with the Pd(II) complex, followed by UV–Vis absorption spectroscopy to estimate a binding constant (Kb) and other thermodynamic parameters. The results indicate that the Pd (II) complex has a high affinity for bind HSA. Thermodynamic analysis showed that the enthalpy (ΔH°) and entropy changes (ΔS°) are positive and Gibbs free energy change (ΔG°) is negative which indicated that hydrophobic interactions played the predominant role in the binding process. Fluorescence spectroscopy were used to show the mechanism and binding parameters of this interaction. Utilizing the Stern–Volmer equation, the Pd(II) complex quenched the intrinsic fluorescence of HSA via a static quenching procedure. The specific binding distances between the tryptophan (donor) proteins and Pd(II) complex (acceptor) were estimated by Forster resonance energy transfer. The CD results also showed the conformational changes on serum albumin upon binding with the Pd(II) complex. © 2016, Taylor & Francis Group, LLC.

Home > Press > Application of Nanostructures; New Approach to Increase Efficiency, Decrease Cost of Solar Cells Abstract: Researchers from Chemistry and Chemical Engineering Research Center of Iran boosted the efficiency of dye sensitized solar cells and reduced their production cost by using specified nanostructures. The research was carried out at laboratorial scale, and nanostructures were synthesized through a simple and economic method with the ability to be mass produced. The aim of the research was to produce dye sensitized solar cells on one-dimensional nanobar basis to optimize and increase the efficiency of conversion of solar energy into electrical one. Titanium dioxide nanobars were produced in this research through a simple method. The proposed method reduces the cost but results in mass production of nanobars at bulk scale. In case the nanobars are mass produced at industrial scale, the quick and economic production solar cells will be achieved. This way, dye sensitized solar cells will be produced at reasonable price with high performance, and this fact reduces the dependency to fossil fuels and environmental pollution. Titanium dioxide nanobars have been mass produced in this research through hydrothermal method. In fact, many parameters can affect the structure and performance of the synthesized nanobars in this method. Nanobar annealing temperature is one of the parameters that affect the final performance of solar cell. Therefore, the effect of annealing temperature on the structure of nanobars and performance of solar cells produced by using the nanobars was studied in this research in details. Results of the research have been published in Journal of the Chinese Chemical Society, vol. 62, issue 9, 2015, pp. 811-816. For more information, please click If you have a comment, please us. Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

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