Chemical Industries Research Division

Chemical Industries Research Division

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Haroun A.A.,Chemical Industries Research Division | Mashaly H.M.,Textile Research Division | Helmy H.M.,Textile Research Division | Kamel M.M.,Textile Research Division
Egyptian Journal of Chemistry | Year: 2017

THE EFFECT of acid red 150 dye (AR150) adsorption parameters onto the prepared gelatin/chitosan/laponite based nanocomposites (NC I, II, III and IV) such as dye concentration, contact time, pH, and sorbent amount using ultrasonic energy had been studied. The standard adsorption affinity through the adsorbent suitability was also carried out. The results revealed that high concentrations of AR150 and chitosan content led to an increasing in the adsorption rate. A comparison between adsorption kinetics of the prepared nanocomposites with conventional and ultrasonic techniques was investigated. The time/dye-uptake isotherms were declared the improvement of dye adsorption in the second phase. Adsorption rate, reaction half-time and standard affinities were also studied. The dye adsorption uptake using ultrasound technique was higher than that in case of the conventional one in case of all the used nanocomposites. On the other hand, in case of using ultrasonic technique, the isotherms showed high dye uptake. In other words, the best dye adsorption rate could be obtained at different nanocomposite concentrations 0.3 and 0.8 g/L in case NCIII and IV, respectively. © 2017 The National Information & Documentation Center (NIDOC).


PubMed | Chemical Industries Research Division
Type: Comparative Study | Journal: Drug development and industrial pharmacy | Year: 2013

This work deals with the preparation, characterization and in vitro release study of IBU-loaded gel graft copolymer nanoparticles.Gelatin (Gel) graft copolymer nanoparticles were prepared using styrene (Sty) and/or 2-hydroxyethyl methacrylate (HEMA) monomers in the presence of potassium persulfate and glutaraldehyde as an initiator and cross-linker, respectively. The prepared nanoparticles as sustained release drug carriers were investigated using the nonsteriodal anti-inflammatory model drug, ibuprofen (IBU).The prepared nanoparticles as sustained release drug carriers were investigated using the nonsteriodal anti-inflammatory model drug, IBU. The prepared Gel/HEMA and Gel/Sty nanoparticles exhibited particles size ranging from 15 to 17nm and from 0.42 to 5mm, respectively. The dissolution of IBU in phosphate buffer, pH 7.4, at 37C from the prepared nanoparticles was evaluated using UV spectroscopy. In addition, the prepared nanoparticles were characterized using Fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), transmitting electron microscope (TEM) and zeta potential/particle size analyzer. In vitro dissolution study showed that the dissolution rates of the crosslinked nanoparticles were retarded relative to the uncrosslinked ones. Moreover, the released amount constantly decreases with increasing gluteraldehyde content in the gel nanoparticles.Crosslinked gel-based graft copolymers exhibited slow IBU release within six hours. Furthermore, results from different characterization techniques such as TEM, particles size and zeta potential measurements confirmed the formation of pH-responsive gel-graft copolymer nanoparticles.

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