Chemical Industry Company Ltd
Chemical Industry Company Ltd
Xing L.-G.,Chemical Industry Ltd. |
Xing L.-G.,Shenyang Pharmaceutical University |
Wu Y.-L.,Shenyang Pharmaceutical University
Chinese Journal of Pharmacology and Toxicology | Year: 2014
Peroxisome proliferator-activated receptors (PPARs) are ligand-activated nuclear transcription factors, playing an important role in the regulation of glucose and lipids metabolism, inflammation response, proliferation and differentiation. Some drugs targeted on PPARs, such as lipid-lowering and antidiabetic drugs have been developed. Some PPAR agonists were found carcinogenic in animal experiments, including PPARα agonist fibrates, PPARγ agonist thiazolidinediones, PPARα/γ dual agonist compounds, and PPARδ agonist compounds for clinical development. PPARα agonist carcinogenicity is associated with PPAR receptor activation that regulates lipid metabolism, and leads to lipids abnormalities and increase by peroxisome oxidase in reactive oxygen species (ROS), causing DNA damage. Kupffer cells can generate ROS by NADPH oxidase that promotes hepatocyte proliferation and inhibition of apoptosis. PPARγ agonist carcinogenicity is generally caused by bladder stone. The carcinogenicity of PPAR agonists to humans has not been confirmed, but the carcinogenic potential of these drugs cannot be ignored.
Li H.-J.,Northwest University, China |
Liu C.-G.,Dalian University of Technology |
Jiao F.,Chemical Industry Corporation |
Lin G.-F.,1st Engineering Co.
Journal of the International Association for Shell and Spatial Structures | Year: 2011
Parametric sensitivity is important for reliability design, optimization and evaluation. The parametric sensitivity and reliability of two typical spatial structures, a star-shaped dome and a lattice truss, are investigated. Four parametric importance measures are employed to identify the relative importance of each random variable under deformation capacity limit state, and the sensitivities of their means and standard deviations on the reliability index are researched. The FOSM (first-order second moment) and the FORM (first-order reliability method) are employed to carry out the sensitivity analysis. The main conclusions are as follows: the influence of the randomness of nodal coordinates on the reliability and sensitivity of these two spatial structures cannot be neglected as it can play an important role; the variables reduction technique (VRT) is an effective way to reduce the considerable computational efforts of reliability analysis for large-scale space structures; the reliabilities of these two structures will decrease with the increase in correlation between the variables.
Song H.,Northeast Petroleum University |
Dong H.,Northeast Petroleum University |
Li F.,Northeast Petroleum University |
Wang S.,Chemical Industry Company Ltd
Petroleum Processing and Petrochemicals | Year: 2012
Pt/TiO 2 catalyst was prepared by microemulsion system of CTAB/butarol/cyclohexane/ H 2PtCl 6 usinghydrazine as reductant and TiO 2 as support. The effect of microemulsion compositions and the crystalline state of TiO 2 on the activities of Pt/TiO 2 catalysts for selective hydrogenation was studied using o-chloronitrobenzene (o-CNB) selective hydrogenation as a probe reaction. The results showed that Pt/TiO 2 catalyst having the highest activity in selective hydrogenation of o-CNB was prepared from a microemulsion system with M ctab M butanol - 3 : 7, (M ctab M butanol) : M cyclohexane=3: 7 and the amount of H 2PtCl 6 solution occupied 3.6% of the total system mass. Furthermore, the study of crystalline states revealed that anatase type TiO 2was helpful to enhance the catalytic activity of Pt/TiO 2 catalyst.
Guan A.-Y.,Chemical Industry Company |
Liu C.-L.,Chemical Industry Company |
Huang G.,Chemical Industry Company |
Li H.-C.,Chemical Industry Company |
And 3 more authors.
Journal of Agricultural and Food Chemistry | Year: 2013
Chlorothalonil with both low cost and low toxicity is a popularly used fungicide in the agrochemical field. The presence of nucleophilic groups on this compound allows further chemical modifications to obtain novel chlorothalonil derivatives. Fluazinam, another commercially available agent with a broad fungicidal spectrum, has a scaffold of diaryl amine structure. To mimic this backbone structure, a variety of (un)substituted phenyl amines was used as nucleophilic agents to react with chlorothalonil to obtain compounds with a diphenyl amine structure. Via an elegant design, two leads, 2,4,5-trichloro-6- (2,4-dichlorophenylamino)isophthalonitrile (7) and 2,4,5-trichloro-6-(2,4,6- trichlorophenylamino)isophthalonitrile (11), with potential fungicidal activity were discovered after a preliminary bioassay screen. These two leads were further modified to obtain final products by replacing the chlorine groups in the phenyl ring in phenyl amine with other functional groups. These functional groups with various electronic properties and spatial characteristics were considered to explore the relationship between structure and fungicidal activity. The results indicate that the electron-withdrawing group NO 2 on the 4 position on the right phenyl ring plays a unique role on enhancing the fungicidal activity. The compounds were identified by proton nuclear magnetic resonance and elemental analysis. Bioassays demonstrated that some of the title compounds exhibited excellent fungicidal activities against cucumber downy mildew at 25 mg/L. Compound 20 has been shown as the optimal structure with 85% control against cucumber downy mildew at 6.25 mg/L concentration. The relationship between structure and fungicidal activity is reported. The present work demonstrates that chlorothalonil derivatives can be used as possible lead compounds for developing novel fungicides. © 2013 American Chemical Society.
Huang X.-F.,Hangzhou Dianzi University |
Li S.-J.,Chemical Industry Ltd. |
Wang G.-Q.,Hangzhou Dianzi University |
Luo D.,Hangzhou Dianzi University |
And 3 more authors.
Asia-Pacific Power and Energy Engineering Conference, APPEEC | Year: 2011
Micropump is one of the key components of MEMS, which has been used widely in many fields. This article focused on the review of micropumps driving and controlling and the application for micro power systems including microturbomachinery, micro fuel cells and microthrusters. © 2011 IEEE.
Cheng L.,Chemical Industry Co. |
Zhang H.-W.,Chemical Industry Co.
Petrochemical Equipment | Year: 2015
According to the problem of shaft concentricity deviation of the syngas compressor turbine in a chemical plant due to stream pipeline stress, the reasons of the accident has been analyzed, and the comprehensive analysis has been made for the solutions for recovering turbine shaft concentricity and eliminating steam pipeline stress. Finally, according to the site situation, the turbine has been made to return to normal by adjusting the cylinder position and changing spring bracket and spring hanger.
Xu F.,Shanxi Institute of Coal CAS Chemistry |
Xu F.,University of Chinese Academy of Sciences |
Dong M.,Shanxi Institute of Coal CAS Chemistry |
Gou W.,Chemical Industry Company |
And 4 more authors.
Microporous and Mesoporous Materials | Year: 2012
Two methods were used to control the crystal size of ZSM-5 synthesized with commercial silica sol. One is use of organic additives; the other is use of colloidal silicalite-1 seed. Addition of polyethylene glycol (PEG) to the synthesis gel favors the formation of relatively small uniform crystals because of promotion of nucleation and somehow hindering the growth of crystals, although it has little influence on the structure, crystallinity, acidity, and crystal shape. The prepared catalyst shows higher catalytic stability than the sample synthesized with the PEG-free gel in the methanol-to-hydrocarbon (MTH) reaction. Finely controllable synthesis of different-sized ZSM-5 crystals was realized by epitaxially growing ZSM-5 crystals around colloidal silicalite-1 seed. The crystal size could be tuned from 200 to 1000 nm by every 100 nm through adjusting the crystallization time and the amount of the added silicalite-1 seed. This makes it possible to systematically study the effect of zeolite crystal size on its catalytic performance and tune product distribution. A significant increase in the catalytic stability was observed with decreasing crystal size for ZSM-5 catalyzing MTH reaction. The crystals with a size of about 270 nm showed a catalytic life of about 6 and 3 times as long as those of the samples synthesized in the absence and presence of PEG respectively. © 2012 Elsevier Inc. All rights reserved.
News Article | November 8, 2016
The report “Adipic Acid Market by Application (Polyamide 66, Polyurethane, Adipic Esters, & Others), by Material Type (Engineering Plastics & Fibers) & by Geography (North America, Europe, Asia-Pacific, & ROW) - Global Trends & Forecast to 2019” report analyzes the adipic acid market with respect to market drivers, opportunities, and trends in different regions. Browse 119 market data tables and 27 figures spread through 217 slides and in-depth TOC on “Adipic Acid Market” The adipic acid market is majorly used as an intermediate of polyamide 66. The adipic acid is also used in polyurethane and adipic esters to manufacture various end products. The Asia-Pacific region dominates this market with its growing demand for adipic acid in the polyamide 66 for different applications; especially, the automotive, electrical & electronics, and other industrial and commercial goods applications. The Asia-Pacific and North America markets are estimated to show a rising growth in the next five years with the allied industries expected to stabilize the overall business need in the respective regions. R&D is a key part of this market. The manufacturing companies, associations, and end-product manufacturers infuse high investments for future advancements and technology modifications to produce bio-based adipic acid as precursor with similar or competitive properties to replace metals and match the new demands coming from various end-user industries. Asia-Pacific is the largest region, both in terms of volume and value, followed by Europe and North America. China, U.S., India, and other countries of Latin America and Russia are expected to continue as successful adipic acid markets. The key players in the Asia-Pacific adipic acid market are Asahi Kasei Corporation (Japan), PetroChina Liaoyang Petrochemical (China), Shandong Haili Chemical Industry Company Ltd. (China), and Shandong Hongye Chemical Company, Ltd. (China). The Eastern and Central European nations and the emerging South-East Asian and Latin American nations that hosts’ the global events would supplement the growth of adipic acid industry. An increase in auto sales, proposals for improvement of infrastructure, and rising housing market in emerging economies will drive the polyamide 66 market, eventually driving the adipic acid market. The demand for polyurethane in garments to household moldings, and also use of adipate esters as a solvent in paints and coatings is expected to rise in future and thus increase the demand for adipic acid. The adipic acid demand, in terms of value and volume, depicts the current and future projections according to the parallel economic and industrial outlook. This analysis covers important developments, expansions, agreements, and mergers & acquisitions of the leading global companies. The estimated market value of adipic acid in 2012 was $5,884.6 million, and is projected to reach $7,539.2 million by 2019, growing at a CAGR of 3.7%, from 2014 to 2019. The high demand across the industries, such as electrical & electronics, consumer goods & appliances, and automotive will increase the overall adipic acid consumption in the polyamide 66 industry.