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Amin R.,Chemical Development | Chen J.-X.,Chemical Development | Cotterill I.C.,Fermentation and Biotransformations | Emrich D.,Chemical Development | And 9 more authors.
Organic Process Research and Development | Year: 2013

A practical synthesis targeting the C16-C20 segment of the endogenous metabolite Resolvin E1 (RvE1) is described. The original route was revised to avoid the use of source-constrained raw materials and chemistries that were problematic on larger scale. The revised route utilizes commercially available (E)-1-chloropent-1-en-3-one as the key raw material to replace (S)-glycidol. The (E)-vinyl iodide functionality was installed by an addition/elimination sequence to prepare the segment required for a subsequent Sonogashira coupling. The chiral secondary hydroxyl group at C18 was established by Corey-Bakshi-Shibata (CBS) reduction followed by lipase-catalyzed acetylation to achieve chiral purity in excess of 98% ee. The revised route offered a viable multikilogram process to support early clinical production of this pro-resolution therapeutic agent. © 2013 American Chemical Society.


Deshpande P.P.,Chemical Development | Singh J.,Process Research and Development | Pullockaran A.,Process Research and Development | Kissick T.,Process Research and Development | And 25 more authors.
Organic Process Research and Development | Year: 2012

A practical synthesis of the SGLT-2 inhibitor β-C-aryl-d-glucoside (1) has been developed. The route employed 2,3,4,6-tetra-O-trimethlysilyl-d- glucano-1,5-lactone as the key chiral building block, prepared efficiently from the commercially available, inexpensive raw materials, d-gluconolactone and trimethylsilyl chloride. The salient step in the synthesis is the Lewis acid-mediated stereoselective reduction of a methyl C-aryl peracetylated glycoside using a silyl hydride to set the stereochemistry of the crucial anomeric chiral center. Several novel cocrystalline complexes of 1 with l-phenylalanine and l-proline were discovered. Single-crystal structures of these complexes and several synthetic intermediates have been determined. The l-phenylalanine complex was developed and used to purify and isolate the API. All steps were implemented at multikilogram scale. © 2012 American Chemical Society.


News Article | November 16, 2016
Site: www.newsmaker.com.au

Notes: Sales, means the sales volume of Cetearyl Alcohol Revenue, means the sales value of Cetearyl Alcohol This report studies sales (consumption) of Cetearyl Alcohol in Global market, especially in United States, China, Europe, Japan, focuses on top players in these regions/countries, with sales, price, revenue and market share for each player in these regions, covering KLK OLEO VVF L.L.C Joshi Group Dr. Straetmans HallStar Company BASF Chemyunion Lubrizol Croda SEPPIC Shanghai Saifu Chemical Development Ashland Inc Lonza Group INOLEX Market Segment by Regions, this report splits Global into several key Regions, with sales (consumption), revenue, market share and growth rate of Cetearyl Alcohol in these regions, from 2011 to 2021 (forecast), like United States China Europe Japan Split by product Types, with sales, revenue, price and gross margin, market share and growth rate of each type, can be divided into Type I Type II Type III Split by applications, this report focuses on sales, market share and growth rate of Cetearyl Alcohol in each application, can be divided into Application 1 Application 2 Application 3 Global Cetearyl Alcohol Sales Market Report 2016 1 Cetearyl Alcohol Overview 1.1 Product Overview and Scope of Cetearyl Alcohol 1.2 Classification of Cetearyl Alcohol 1.2.1 Type I 1.2.2 Type II 1.2.3 Type III 1.3 Application of Cetearyl Alcohol 1.3.1 Application 1 1.3.2 Application 2 1.3.3 Application 3 1.4 Cetearyl Alcohol Market by Regions 1.4.1 United States Status and Prospect (2011-2021) 1.4.2 China Status and Prospect (2011-2021) 1.4.3 Europe Status and Prospect (2011-2021) 1.4.4 Japan Status and Prospect (2011-2021) 1.5 Global Market Size (Value and Volume) of Cetearyl Alcohol (2011-2021) 1.5.1 Global Cetearyl Alcohol Sales and Growth Rate (2011-2021) 1.5.2 Global Cetearyl Alcohol Revenue and Growth Rate (2011-2021) 2 Global Cetearyl Alcohol Competition by Manufacturers, Type and Application 2.1 Global Cetearyl Alcohol Market Competition by Manufacturers 2.1.1 Global Cetearyl Alcohol Sales and Market Share of Key Manufacturers (2011-2016) 2.1.2 Global Cetearyl Alcohol Revenue and Share by Manufacturers (2011-2016) 2.2 Global Cetearyl Alcohol (Volume and Value) by Type 2.2.1 Global Cetearyl Alcohol Sales and Market Share by Type (2011-2016) 2.2.2 Global Cetearyl Alcohol Revenue and Market Share by Type (2011-2016) 2.3 Global Cetearyl Alcohol (Volume and Value) by Regions 2.3.1 Global Cetearyl Alcohol Sales and Market Share by Regions (2011-2016) 2.3.2 Global Cetearyl Alcohol Revenue and Market Share by Regions (2011-2016) 2.4 Global Cetearyl Alcohol (Volume) by Application Figure Picture of Cetearyl Alcohol Table Classification of Cetearyl Alcohol Figure Global Sales Market Share of Cetearyl Alcohol by Type in 2015 Figure Type I Picture Figure Type II Picture Table Applications of Cetearyl Alcohol Figure Global Sales Market Share of Cetearyl Alcohol by Application in 2015 Figure Application 1 Examples Figure Application 2 Examples Figure United States Cetearyl Alcohol Revenue and Growth Rate (2011-2021) Figure China Cetearyl Alcohol Revenue and Growth Rate (2011-2021) Figure Europe Cetearyl Alcohol Revenue and Growth Rate (2011-2021) Figure Japan Cetearyl Alcohol Revenue and Growth Rate (2011-2021) Figure Global Cetearyl Alcohol Sales and Growth Rate (2011-2021) Figure Global Cetearyl Alcohol Revenue and Growth Rate (2011-2021) Table Global Cetearyl Alcohol Sales of Key Manufacturers (2011-2016) Table Global Cetearyl Alcohol Sales Share by Manufacturers (2011-2016) Figure 2015 Cetearyl Alcohol Sales Share by Manufacturers Figure 2016 Cetearyl Alcohol Sales Share by Manufacturers Table Global Cetearyl Alcohol Revenue by Manufacturers (2011-2016) Table Global Cetearyl Alcohol Revenue Share by Manufacturers (2011-2016) Table 2015 Global Cetearyl Alcohol Revenue Share by Manufacturers Table 2016 Global Cetearyl Alcohol Revenue Share by Manufacturers Table Global Cetearyl Alcohol Sales and Market Share by Type (2011-2016) Table Global Cetearyl Alcohol Sales Share by Type (2011-2016) Figure Sales Market Share of Cetearyl Alcohol by Type (2011-2016) Figure Global Cetearyl Alcohol Sales Growth Rate by Type (2011-2016) Table Global Cetearyl Alcohol Revenue and Market Share by Type (2011-2016) FOR ANY QUERY, REACH US @    Cetearyl Alcohol Sales Global Market Research Report 2016


Mortensen M.A.,Chemical Development | Guo C.,Discovery RandD | Reynolds N.T.,Chemical Development | Wang L.,Chemical Development | And 8 more authors.
Organic Process Research and Development | Year: 2012

Process development and production of a novel tubulin inhibitor are described. The desired API was obtained through selective iodination of the 12′ position of vinblastine and subsequent thiomethylation. Most of the impurities were identified, and process parameters were adjusted to control such impurities. The optimized process was scaled up under cGMP conditions to afford 230 g of the desired API. © 2012 American Chemical Society.


Guz N.R.,Exelixis Inc. | Leuser H.,Chemical Development | Goldman E.,Exelixis Inc.
Organic Process Research and Development | Year: 2013

Route scouting, process development, and multikilogram syntheses of an IGF-1R/Src/Bcr-Abl inihibitor are reported. Key aspects of the developed route are a regioselective [3 + 2] isoxazole formation on a pyrimidine core and a selective SNAr addition of an aryl amine to a symmetrical dichloro substituted pyrimidine. The route contains six synthetic steps and was demonstrated twice on scale, delivering 4.6 and 11.2 kg (25% and 16% overall yield), for Phase I clinical studies. © 2013 American Chemical Society.


Zhu D.,Scripps Research Institute | Yang G.,Scripps Research Institute | He J.,Scripps Research Institute | Chu L.,Scripps Research Institute | And 5 more authors.
Angewandte Chemie - International Edition | Year: 2015

2,4,6-Trimethoxypyridine is identified as an efficient ligand for promoting a Pd-catalyzed ortho-C-H amination of both benzamides and triflyl-protected benzylamines. This finding provides guidance for the development of ligands that can improve or enable PdII-catalyzed Csp2-H activation reactions directed by weakly coordinating functional groups. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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