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Imeni Vorovskogo, Russia

Bogdanov D.V.,Chelyabinsk State Medical Academy

We examined 86 patients with various forms and variants of hypertrophic cardiomyopathy (HCM). Examination of 69 patients with nonobstructive form of the disease included echocardiography. The state of left atrium (LA) was studied by measurement of its systolic and diastolic longitudinal and transversal dimensions with calculation of main parameters of contractility. In 60% of patients with HCM including those with nonobstuctive form we found spherical remodeling of LA with lowering of its contractility. Coefficient of remodeling was suggested as ratio of transversal and longitudinal dimensions of its cavity. In control group mean value of this parameter was equal to 0.38±0.G1 relative units, in the group of patients with nonobstructive HCM - 0.61 ±0.02 units (p<0.05). Source

Sushko I.,EADMET GmbH | Salmina E.,Russian Academy of Sciences | Potemkin V.A.,Chelyabinsk State Medical Academy | Poda G.,Ontario Cancer Institute | And 2 more authors.
Journal of Chemical Information and Modeling

The article presents a Web-based platform for collecting and storing toxicological structural alerts from literature and for virtual screening of chemical libraries to flag potentially toxic chemicals and compounds that can cause adverse side effects. An alert is uniquely identified by a SMARTS template, a toxicological endpoint, and a publication where the alert was described. Additionally, the system allows storing complementary information such as name, comments, and mechanism of action, as well as other data. Most importantly, the platform can be easily used for fast virtual screening of large chemical datasets, focused libraries, or newly designed compounds against the toxicological alerts, providing a detailed profile of the chemicals grouped by structural alerts and endpoints. Such a facility can be used for decision making regarding whether a compound should be tested experimentally, validated with available QSAR models, or eliminated from consideration altogether. The alert-based screening can also be helpful for an easier interpretation of more complex QSAR models. The system is publicly accessible and tightly integrated with the Online Chemical Modeling Environment (OCHEM, http://ochem.eu). The system is open and expandable: any registered OCHEM user can introduce new alerts, browse, edit alerts introduced by other users, and virtually screen his/her data sets against all or selected alerts. The user sets being passed through the structural alerts can be used at OCHEM for other typical tasks: exporting in a wide variety of formats, development of QSAR models, additional filtering by other criteria, etc. The database already contains almost 600 structural alerts for such endpoints as mutagenicity, carcinogenicity, skin sensitization, compounds that undergo metabolic activation, and compounds that form reactive metabolites and, thus, can cause adverse reactions. The ToxAlerts platform is accessible on the Web at http://ochem.eu/alerts, and it is constantly growing. © 2012 American Chemical Society. Source

Manoylov A.E.,Chelyabinsk State Medical Academy

We studied awareness of physicians of the city health clinics (polyclinics) about the causes of heart failure in hypertensive patients and their attitude to the prevention of complications of hypertension. The study involved 194 general practitioners from five regions of Russia. The questionnaire method in the form of single-blind questionnaire survey was used. It was found that 36.6% (95% confidence interval [Di] from 29.81to 43.80) of respondents were aware of the cause-effect relation between hypertension and heart failure. Only 31.44% (95% DI from 24.98 to 38.48) medical professionals perceived left ventricular hypertrophy as risk factor for heart failure in people with high blood pressure. The percentage of internists-respondents who were aware of the major mechanisms of heart failure in hypertension was 28.37% (95% DI from 21.18 to 4.16]. Outdated or incorrect professional notions can become a barrier to early diagnosis, treatment and prevention of heart failure in patients with hypertension. Source

Garbuzenko D.V.,Chelyabinsk State Medical Academy
Vestnik Rossiiskoi Akademii Meditsinskikh Nauk

The data of the literature on the mechanisms of restructuring of vascular bed in response to hemodynamic changes due to portal hypertension. Despite the fact that these changes are compensatory-adaptive reaction to the deteriorating conditions of blood circulation, they contribute to its progression, promoting the development of serious complications, one of which was bleeding from esophageal varices. Source

Zorina I.G.,Chelyabinsk State Medical Academy
Vestnik Rossiiskoi Akademii Meditsinskikh Nauk

Environmentalactor is one of the most accurate indicators of determining the health of the population, especially in childhood and adolescence. A significant increase in the amount of data on the status of school health and the environment are the most precise and correct, in view of causation, to evaluate an individual's health at prenosological level in the presence of a specialized database of automated systems. The aim of our study the study of fundamental interactions and patterns of environmental factors in general and neuropsychiatrie disease in schoolchildren of the city of Chelyabinsk. Revealed that among the multi-pollutant air Chelyabinsk first and second rank positions are occupied by selectively harmful to the central nervous system (lead, arsenic, manganese), or have complex adverse effects on the central nervous system, combined with damaging effects on the respiratory and cardio- vascular, urogenital system and blood forming organs, involving the immune mechanism (chromium compounds, lead, arsenic, carbon monoxide and manganese). Source

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