Chatham University is an American university that has coeducational academic programs through the doctoral level, located in the Shadyside neighborhood of Pittsburgh, Pennsylvania, United States. The current campus population of approximately 2,300 includes on-campus and online undergraduate and graduate students. The University grants certificates and degrees including bachelor, master, first-professional, and doctorate in the School of Arts, Science, and Business, the School of Health science, and the Falk School of Sustainability. Wikipedia.
Habib M.,Chatham University
Biological Journal of the Linnean Society | Year: 2010
Mass-specific bone strength was examined in the forelimb and hindlimb of 64 species of birds to determine if aquaflying birds (which utilize the wings for propulsion underwater) differ in their skeletal strength compared with other avian taxa. Long bone strengths were estimated from cross-sectional measurements. Compared with the expectation from geometric similarity, humeral section modulus in volant birds scales nearly isometrically, while femoral strength scales with significant positive allometry. Penguin mass-specific humeral strength is greatly elevated, but the average humeral strength in species that are propelled by the wings in both air and water do not differ from the values calculated in non-diving taxa. However, amphibious flyers have gracile femora. Comparative analyses using independent contrasts were utilized to examine the impact of phylogenetic signal. The residual measured for the penguin-procellariiform humeral strength contrast was larger in magnitude (residual of 2.14) than at any other node in the phylogeny. The data strongly indicate that the transition from an amphibious flight condition to a fully aquatic condition involves greater changes in mechanical factors than the transition from purely aerial locomotion to amphibious wing use. There remains the possibility that a historical effect, such as ancestral body size, has impacted the mechanical scaling of penguins. © 2010 The Linnean Society of London.
Lambert L.A.,Chatham University
Biochimica et Biophysica Acta - General Subjects | Year: 2012
Background: In vertebrates, serum transferrins are essential iron transporters that have bind and release Fe(III) in response to receptor binding and changes in pH. Some family members such as lactoferrin and melanotransferrin can also bind iron while others have lost this ability and have gained other functions, e.g., inhibitor of carbonic anhydrase (mammals), saxiphilin (frogs) and otolith matrix protein 1 (fish). Scope of review: This article provides an overview of the known transferrin family members and their associated receptors and interacting partners. Major conclusions: The number of transferrin genes has proliferated as a result of multiple duplication events, and the resulting paralogs have developed a wide array of new functions. Some homologs in the most primitive metazoan groups resemble both serum and melanotransferrins, but the major yolk proteins show considerable divergence from the rest of the family. Among the transferrin receptors, the lack of TFR2 in birds and reptiles, and the lack of any TFR homologs among the insects draw attention to the differences in iron transport and regulation in those groups. General significance: The transferrin family members are important because of their clinical significance, interesting biochemical properties, and evolutionary history. More work is needed to better understand the functions and evolution of the non-vertebrate family members. This article is part of a Special Issue entitled Molecular Mechanisms of Iron Transport and Disorders. © 2011 Elsevier B.V. All rights reserved.
Li T.,University of Pittsburgh |
Kozlowski M.T.,University of Pittsburgh |
Doud E.A.,University of Pittsburgh |
Blakely M.N.,Chatham University |
Rosi N.L.,University of Pittsburgh
Journal of the American Chemical Society | Year: 2013
A stepwise ligand exchange strategy is utilized to prepare a series of isoreticular bio-MOF-100 analogues. Specifically, in situ ligand exchange with progressively longer dicarboxylate linkers is performed on single crystalline starting materials to synthesize products with progressively larger mesoporous cavities. The new members of this series of materials, bio-MOFs 101-103, each exhibit permanent mesoporosity and pore sizes ranging from ∼2.1-2.9 nm and surface areas ranging from 2704 to 4410 m2/g. The pore volume for bio-MOF 101 is 2.83 cc/g. Bio-MOF-102 and 103 have pore volumes of 4.36 and 4.13 cc/g, respectively. Collectively, these data establish this unique family of MOFs as one of the most porous reported to date. © 2013 American Chemical Society.
Viehland L.A.,Chatham University
International Journal for Ion Mobility Spectrometry | Year: 2012
The zero-field mobilities of 46 atomic ions in helium are calculated as functions of the gas temperature in an ion mobility spectrometer. The calculations are based on highly accurate, ab initio potential energy curves obtained in the last few years. In general, they start from a small value at low temperature, rise steadily to a maximum at some specific temperature, T max, and then decline at higher temperatures. The ratio of T max to the dissociation energy (well depth) of the ion-neutral interaction potential is shown to be approximation the same for all singly-charged ions and a few multiply-charged ions. © 2011 Springer-Verlag.
Karas S.,Chatham University
Asian Journal of Sports Medicine | Year: 2012
Purpose: We performed a systematic review to assess the functional outcomes of Birmingham Hip Resurfacing as reported in peer-reviewed literature. Methods: We performed a computerized search on the data sources up to February 2011. The following text and key words were searched: "Birmingham hip", "Birmingham hip resurfacing" and "Hip resurfacing". Each of these key words was again searched with "outcomes" following them. We also hand searched the bibliographies of the retrieved articles and our own files to identify specifically relevant articles. Results: Fourteen retrospective studies and three prospective studies were included for review. Each of these studies was evaluated by the criteria given by Sackett and AACPDM. The design, patient criteria, intervention, outcomes, duration of follow up and results of the research were reported. Conclusions: Although the technique of BHR does allow the femur to be spared, claims that it may allow patients to be more active need to be further investigated. © 2012 by Sports Medicine Research Center, Tehran University of Medical Sciences.