Wilmington, MA, United States

Charles River Laboratories International

www.criver.com
Wilmington, MA, United States
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Patent
Charles River Laboratories International | Date: 2017-03-13

The invention relates to a filtration system for use in a method of determining the presence and/or amount of cells, for example, viable cells, in a liquid sample, and to methods of using and manufacturing such a filtration system. The filtration system includes a cup with an upper portion and a ring portion, where the ring portion is separably coupled to the upper portion.


Patent
Charles River Laboratories International | Date: 2014-09-12

Systems and methods for object identification. Objects in a color image of a biological sample are identified by using a signal function to transform the color image into a single-channel image with localized extrema. The localized extrema may be segmented into objects by an iterative thresholding process and a merit function may be used to determine the quality of a given result.


Patent
ReaMetrix and Charles River Laboratories International | Date: 2013-05-02

The invention relates to a method for determining the presence and/or amount of viable cells in a liquid sample.


Patent
Charles River Laboratories International | Date: 2015-09-18

The invention relates to a filtration system for use in a method of determining the presence and/or amount of cells, for example, viable cells, in a liquid sample, and to methods of using and manufacturing such a filtration system. The filtration system includes a cup with an upper portion and a ring portion, where the ring portion is separably coupled to the upper portion.


Patent
Charles River Laboratories International | Date: 2014-03-28

The application provides heat-treated Limulus amebocyte lysates useful for detecting -glucans.


Patent
Charles River Laboratories International | Date: 2014-07-07

Methods and apparatus for the interactive display of images and measurements of samples. A user may interact with embodiments of the present invention to display measurements for a set of biological samples and subsequently display images associated with particular biological samples of interest. For example, selecting data indicators in the set may result in the display of an image associated with a biological sample as well as one or more overlays presenting information of interest as well as controls affecting the display of the image or the information.


Patent
Charles River Laboratories International | Date: 2015-02-19

The invention relates to a method of detecting viable cells in a cell sample, using a membrane permeable fluorescent label that permeates both viable and non-viable cells and a membrane impermeant quencher that selectively permeates non-viable cells.


Patent
Charles River Laboratories International | Date: 2015-02-19

The invention relates to a method of detecting viable cells in a cell sample, using a membrane permeable fluorescent label that permeates both viable and non-viable cells and a membrane impermeant quencher that selectively permeates non-viable cells.


Patent
Charles River Laboratories International | Date: 2014-11-04

The invention relates to a method for determining the presence and/or amount of viable cells in a cell containing sample, for example, a fluid sample, using a dye precursor selected from the group consisting of a bioactivatable tetrazolium dye and a bioactivatable esterase dye, where the dye precursor is converted into a fluorescent label by a viable cell.


Patent
Charles River Laboratories International and Allentown Inc. | Date: 2016-06-01

Embodiments of the present disclosure are directed to systems and methods for collection and analysis of environmental air dust (EAD) within an individually ventilated cage rack (IVR) environment for detecting pathogens. The method includes collection of an EAD sample by a collection media, isolation of a plurality of nucleic acids (e.g., RNA and/or DNA) representative of one or more infectious agents from the EAD sample, optional reverse transcription of RNA to cDNA if the isolated nucleic acids contain RNA, amplification of the cDNA and/or DNA (e.g., by polymerase chain reaction (PCR)), and assay interpretation. Optionally, the EAD sample may be analyzed with one or more other sample types (e.g., fecal pellets, oral swabs, body swabs, tissue, etc.) to improve detection of low-copy organisms.

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