Charles Perrens Hospital

Bordeaux, France

Charles Perrens Hospital

Bordeaux, France

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PubMed | Academic Hospital of Grenoble, Academic Hospital of Versailles, Montpellier University, FondaMental Foundation and 6 more.
Type: | Journal: Journal of affective disorders | Year: 2015

The aim of our study was to investigate, in bipolar patients, the association between tobacco status (use and dependence) and history of suicide attempt, and to assess the possible role of inflammation as a missing link in the association between smoking status and history of suicide attempt.A total of 453 adult bipolar out-patients recruited in the French FondaMental Advanced Centres of Expertise for Bipolar Disorder were divided into two subgroups: 274 patients without past history of suicide attempt (non-SA), and 179 patients with a past history of suicide attempt (SA). Tobacco use and dependence, psychiatric and somatic comorbidities, history of childhood abuse, family history of suicide were assessed. Fasting blood tests yielded samples collected for the measurement of high sensitivity (hs-)CRP.The risk of suicide attempt increased with smoking dependence. Notably, bipolar patients with a history of suicide attempt were three times more likely to have severe tobacco dependence, independently of confounding factors. However, we failed to find arguments promoting the hypothesis of inflammatory markers (through hs-CRP measure) in the link between tobacco dependence and suicidal behavior.We found a significant association between severe tobacco dependence and history of suicide attempt, but not with level of CRP, independently of confusing factors. Longitudinal studies taken into account all these potential confusing factors are needed to confirm our results.


PubMed | Academic Hospital of Grenoble, Academic Hospital of Versailles, Montpellier University, FondaMental Foundation and 6 more.
Type: | Journal: Journal of affective disorders | Year: 2016

Poor quality of sleep is frequent in euthymic bipolar patients and conveys worse clinical outcomes. We investigated the features of euthymic bipolar patients associated with poor sleep quality, with a focus on the effect of childhood trauma.493 euthymic patients with DSM-IV-defined bipolar disorders were recruited in FondaMental Advanced Centers of Expertize for Bipolar Disorders (FACE-BD) between 2009 and 2014. Clinical variables were recorded. Subjective sleep quality and history of childhood trauma were respectively measured by the Pittsburgh Sleep Quality Index (PSQI) and the Childhood Trauma Questionnaire (CTQ).Poor sleepers were older, less professionally active, had significantly higher anxiety levels, took more anxiolytic drugs and did endorse more suicide attempts and suicidal ideas than good sleepers after adjusting for anxiety levels and age. Emotional abuse was associated with poor sleep quality after adjustment for BMI, age, professional activity, and bipolar disorders (BD) type (OR=1.83; 95% CI [1.30; 3.10]; p=0.02). However, this association was lost after adjustment for anxiety levels, anxiolytic treatment and suicide ideation/attempts.The main limitation was the type of sleep assessment, which only measured the subjective part of sleep complaints.A history of emotional abuse might underlie sleep problems in many bipolar patients but anxiety seems to act as a confounding factor in this relationship. New studies are needed to elucidate the role of childhood maltreatment on poor sleep among bipolar patients.


van der Waerden J.,French Institute of Health and Medical Research | Galera C.,Charles Perrens Hospital | Saurel-Cubizolles M.-J.,Paris-Sorbonne University | Sutter-Dallay A.-L.,Bordeaux University | Melchior M.,French Institute of Health and Medical Research
Psychological medicine | Year: 2015

BACKGROUND: Maternal depression in the pre- and postpartum period may set women on a course of chronic depressive symptoms. Little is known about predictors of persistently elevated depressive symptoms in mothers from pregnancy onwards. The aims of this study are to determine maternal depression trajectories from pregnancy to the child's fifth birthday and identify associated risk factors.METHOD: Mothers (N = 1807) from the EDEN mother-child birth cohort study based in France (2003-2011) were followed from 24-28 weeks of pregnancy to their child's fifth birthday. Maternal depression trajectories were determined with a semi-parametric group-based modelling strategy. Sociodemographic, psychosocial and psychiatric predictors were explored for their association with trajectory class membership.RESULTS: Five trajectories of maternal symptoms of depression from pregnancy onwards were identified: no symptoms (60.2%); persistent intermediate-level depressive symptoms (25.2%); persistent high depressive symptoms (5.0%); high symptoms in pregnancy only (4.7%); high symptoms in the child's preschool period only (4.9%). Socio-demographic predictors associated with persistent depression were non-French origin; psychosocial predictors were childhood adversities, life events during pregnancy and work overinvestment; psychiatric predictors were previous mental health problems, psychological help, and high anxiety during pregnancy.CONCLUSIONS: Persistent depression in mothers of young children is associated to several risk factors present prior to or during pregnancy, notably anxiety. These characteristics precede depression trajectories and offer a possible entry point to enhance mother's mental health and reduce its burden on children.


PubMed | French Institute of Health and Medical Research, Ecole Normale Superieure de Paris, Corentin Celton Hospital, University of Paris Descartes and Charles Perrens Hospital
Type: Journal Article | Journal: BMC psychiatry | Year: 2016

This study aims to examine bidirectional relationships between childrens language skills and Inattention/Hyperactivity (IH) symptoms during preschool.Children (N=1459) from the EDEN mother-child cohort were assessed at ages 3 and 5.5years. Language skills were evaluated using the WPPSI-III, NEPSY and ELOLA batteries. Childrens behavior, including IH symptoms, was assessed using the parent-rated Strengths & Difficulties Questionnaire (SDQ). Using a Structural Equation Modeling (SEM) approach, we examined the relationship between language skills and IH symptoms, as well as potential mediating processes.SEM analyses indicated a small negative effect of language skills at 3years on ADHD symptoms at 5.5years after adjusting for IH symptoms at 3years (=-0.12, SE=0.04, p-value=0.002). Interpersonal difficulties did not mediate the relationship between early language skills and later IH symptoms, nor was this association reduced after adjusting for a broad range of pre- and postnatal environmental factors and performance IQ. Among different language skills, receptive syntax at 3years was most strongly related to IH symptoms at 5.5years.Poor language skills at age 3 may predict IH symptoms when a child enters primary school. Implications for the understanding and the prevention of the co-occurrence of language disorders and ADHD are discussed.


PubMed | Bordeaux University, French Institute of Health and Medical Research, Paris-Sorbonne University and Charles Perrens Hospital
Type: Journal Article | Journal: Psychological medicine | Year: 2015

Maternal depression in the pre- and postpartum period may set women on a course of chronic depressive symptoms. Little is known about predictors of persistently elevated depressive symptoms in mothers from pregnancy onwards. The aims of this study are to determine maternal depression trajectories from pregnancy to the childs fifth birthday and identify associated risk factors.Mothers (N=1807) from the EDEN mother-child birth cohort study based in France (2003-2011) were followed from 24-28 weeks of pregnancy to their childs fifth birthday. Maternal depression trajectories were determined with a semi-parametric group-based modelling strategy. Sociodemographic, psychosocial and psychiatric predictors were explored for their association with trajectory class membership.Five trajectories of maternal symptoms of depression from pregnancy onwards were identified: no symptoms (60.2%); persistent intermediate-level depressive symptoms (25.2%); persistent high depressive symptoms (5.0%); high symptoms in pregnancy only (4.7%); high symptoms in the childs preschool period only (4.9%). Socio-demographic predictors associated with persistent depression were non-French origin; psychosocial predictors were childhood adversities, life events during pregnancy and work overinvestment; psychiatric predictors were previous mental health problems, psychological help, and high anxiety during pregnancy.Persistent depression in mothers of young children is associated to several risk factors present prior to or during pregnancy, notably anxiety. These characteristics precede depression trajectories and offer a possible entry point to enhance mothers mental health and reduce its burden on children.


Atzeni T.,University of Bordeaux Segalen | Henry C.,Henri Mondor Albert Chenevier Hospitals | Henry C.,French Institute of Health and Medical Research | Henry C.,University Paris Est Creteil | And 6 more authors.
Psychiatry Research | Year: 2013

To better explore the clinical heterogeneity of bipolar mood states, we developed a dimensional scale for assessing all mood episodes (depressive, hypomanic, manic, mixed states) using the same tool. The Multidimensional Assessment of Thymic States (MATHYS) (Henry et al., 2008) provides two scores, a total score measuring a level of activation and a sub-score of emotional reactivity. The aim of this study was to establish the appropriate cut-off in total activation versus inhibition and in the emotional reactivity sub-score in bipolar disorders. Patients (n = 187) during an acute episode and controls (n=89) filled in the MATHYS. Receiver Operating Characteristic (ROC) curves were obtained to estimate the sensitivity and specificity of the global score and the emotional reactivity sub-score of the MATHYS, in order to differentiate patients from controls. ROC curves showed very satisfactory sensitivity and specificity levels both for the total score and the sub-score of emotional reactivity, thus providing an appropriate cut-off. Concerning the total score between 0 and 200, patients with a score lower than 91 had significant global inhibition and those with a score higher than 109 had significant global activation. Regarding the emotional reactivity sub-score between 0 and 40, patients with a score lower than 16 had significant emotional hyporeactivity and those with a score higher than 24 had significant emotional hyperreactivity. Our results provide cut-offs for the MATHYS to identify patients in an acute phase. © 2012 Elsevier Ireland Ltd.


Jean F.A.M.,University of Bordeaux 1 | Jean F.A.M.,French National Center for Scientific Research | Jean F.A.M.,Charles Perrens Hospital | Swendsen J.D.,University of Bordeaux 1 | And 5 more authors.
Journal of Geriatric Psychiatry and Neurology | Year: 2013

Approximately one-third of stroke survivors have symptoms of depression. A better understanding of the early risk factors implicated in this form of comorbidity may contribute to the development of early prevention strategies and to improving outcomes for this population. The current study uses ecological momentary assessment techniques to identify behavioral risk factors for depression 3 months after stroke. Thirty-six participants completed ambulatory monitoring of daily life circumstances (location, social environment, and activity) 5 times per day during a 1-week period after hospital discharge. Clinician-administered measures of depression were also provided before discharge and 3 months later. Ambulatory monitoring revealed that depression scores at 3 months were lower among individuals with more social interactions but higher among those who reported having sports activities and working in the week following hospital discharge. Daily life behaviors may have important implications for understanding the risk of poststroke depression, and mobile technologies may provide important contributions to their investigation. © The Author(s) 2013.


Rotge J.-Y.,Charles Perrens Hospital | Rotge J.-Y.,University of Bordeaux Segalen | Grabot D.,Charles Perrens Hospital | Aouizerate B.,Charles Perrens Hospital | And 4 more authors.
Journal of Affective Disorders | Year: 2011

Background: Behavioral inhibition (BI), a heritable temperament, predisposes one to an increased risk of social phobia. Recent investigations have reported that BI may also be a precursor to anxiety as well as depressive and alcohol-related disorders, which are frequently comorbid with social phobia. In the present study, we explored the relationship between BI and psychiatric disorders in 256 adults with a primary diagnosis of social phobia. Methods: BI severity was retrospectively assessed with the Retrospective Self-Report of Inhibition (RSRI). The severity of social phobia and the presence of comorbid diagnoses were evaluated with the Liebowitz Social Anxiety Scale (LSAS) and the Mini-International Neuropsychiatric Interview, respectively. Results: The RSRI score was significantly and positively correlated with both the LSAS score and the occurrence of a major depressive disorder. No significant association was found with other anxiety and substance-related disorders. Limitation: The assessment of BI was retrospective and self-reported. Conclusion: A childhood history of BI was associated with an increased risk of depressive comorbidity in social phobia. © 2010 Elsevier B.V. All rights reserved.


Gaiffas A.,Charles Perrens Hospital | Gaiffas A.,University of Bordeaux Segalen | Galera C.,Charles Perrens Hospital | Galera C.,French Institute of Health and Medical Research | And 4 more authors.
Journal of Forensic Sciences | Year: 2014

While forensic studies have reported higher than community rates of mental disorders in imprisoned populations, few studies have focused on attention-deficit/hyperactivity disorder (ADHD) in these subjects. The aim of this study was to investigate ADHD prevalence among young French male prisoners. A specific diagnostic interview (Conners' Adult ADHD Diagnostic Interview for DSM-IV, CAADID) was used. Correlations between ADHD, subsyndromal ADHD, and criminal features were investigated. 11% of young male prisoners among 93 male subjects aged 18-35 years met the criteria for actual ADHD, and 17% met those for childhood ADHD. Considering ADHD and subsyndromal ADHD, prevalence was about 43% in adulthood. ADHD and subsyndromal ADHD in adulthood were significantly associated with a higher number of imprisonments and a younger age at first arrest. It could be advisable to better identify subjects with ADHD symptoms among prison populations. © 2014 American Academy of Forensic Sciences.


PubMed | University of Bordeaux 1 and Charles Perrens Hospital
Type: Journal Article | Journal: Journal of autism and developmental disorders | Year: 2016

This study aimed to identify parental stress predictors in ASD by considering individual and environmental factors in an ecological approach. Participants were 115 parents of children with ASD aged from 3 to 10years. Multiple regression analyses were conducted to determine the best predictors of parental stress among child-related, parent-related and environmental factors. Poor quality interactions within the extended family, high levels of expressed emotion and absence of childrens schooling were associated with higher stress, regardless of the childs age and developmental quotient [F (3)=37.051; p<0.001; Adj. R(2)=0.457]. This study highlights the importance of considering environmental factors, specifically family variables, to understand parental stress. These key findings should be considered when designing support programs.

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