Braun F.C.M.,University of Greifswald |
Grabarczyk P.,University of Greifswald |
Mobs M.,Chariteumboldt University Berlin |
Braun F.K.,Chariteumboldt University Berlin |
And 9 more authors.
Leukemia | Year: 2011
Despite recent therapeutic improvements, the prognosis for patients suffering from Sézary syndrome (SS), a disseminated form of cutaneous T-cell lymphomas, is still poor. We identified bi-and monoallelic deletions of the tumor necrosis factor-α-induced protein 3 gene (TNFAIP3; A20) in a high proportion of SS patients as well as biallelic A20 deletion in the SS-derived cell line SeAx. Furthermore, we demonstrate that inhibition of A20 activates the NF-B pathway thereby increasing the proliferation of normal T lymphocytes. On the other hand, the reconstitution of A20 expression slowed down the cell cycle in SeAx cells. Recently A20 inactivation has been reported in various B-cell lymphomas. In this study, we show that A20 is also a putative tumor suppressor in the T-cell malignancySS. © 2011 Macmillan Publishers Limited All rights reserved.