Chaonan Minsheng Hospital of Shantou

Shantou, China

Chaonan Minsheng Hospital of Shantou

Shantou, China
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Yin J.-J.,Shantou University | Yin J.-J.,Chaonan Minsheng Hospital of Shantou | Yin J.-J.,Guangdong Key Laboratory of Medical Molecular Imaging | Ma S.-H.,Shantou University | And 15 more authors.
Clinical Imaging | Year: 2012

The study aimed to explore the abnormal activation of special brain areas associated with methamphetamine craving using functional magnetic resonance imaging (fMRI) and to reveal the neurobiological basis of addiction. Twenty-six methamphetamine addicts and 26 healthy subjects were scanned by brain fMRI while watching pictures of happy, sad, or methamphetamine to acquire resource data. SPM5 was used to analyze fMRI data to get related brain activation map, and it was found that methamphetamine addicts had high brain activation in cingulate and low activation in frontal lobe when watching methamphetamine-cue pictures. This study demonstrated that methamphetamine addicts had emotion-related brain activation abnormalities. © 2012 Elsevier Inc.

Yin J.-J.,Shantou University | Yin J.-J.,Chaonan Minsheng Hospital of Shantou | Yin J.-J.,Guangdong Key Laboratory of Medical Molecular Imaging | Liao L.-M.,Sun Yat Sen University | And 20 more authors.
Neuroendocrinology | Year: 2013

Objective: Using a block-designed BOLD-fMRI to explore the neural basis of spatial working memory impairment in patients with subclinical hypothyroidism (SCH) performing an n-back task. Methods: Sixteen patients with SCH before and after being treated with levothyroxine (LT4) for 6 months and 16 matched euthyroid subjects were scanned by fMRI under the n-back task. Results: The fMRI scan found that a neural network consisting of bilateral dorsolateral prefrontal cortex (DLPFC), bilateral premotor area (PreMA), supplementary motor area/anterior cingulate cortex, bilateral parietal lobe (PA) and right caudate nucleus/thalamus was activated, with right hemisphere dominance. In euthyroid subjects, all these regions of interest (ROIs) showed load effect; however, only left DLPFC, left PA, bilateral PreMA and right caudate nucleus/thalamus showed the same effect in Pre-SCH patients. Furthermore, activation intensities of most ROIs (especially DLPFC and right PA) for Pre-SCH patients were lower than those in the euthyroid subjects (F <3.046, p > 0.062). Importantly, after a 6-month treatment with LT4, the load effect in SCH patients appeared the same as in the euthyroid subjects in all the ROIs (F >13.176, p < 0.0001). Conclusion: Our previous study shows that verbal working memory of SCH patients is impaired with abnormal activity in bilateral frontal areas. In this study, the results indicated that SCH patients may also have spatial working memory impairments, and the altered activities of right DLPFC and right posterior parietal lobe may be one of the underlying neural mechanisms. Most importantly, this study shows that LT4 replacement therapy can improve the memory impairment and reverse the altered neural activity network. Copyright © 2012 S. Karger AG, Basel.

Huang R.-R.,Shantou University | Huang R.-R.,Chaonan Minsheng Hospital of Shantou | Huang R.-R.,Guangdong Key Laboratory of Medical Molecular Imaging | Ma S.-H.,Shantou University | And 4 more authors.
Chinese Journal of Medical Imaging Technology | Year: 2013

Diabetes mellitus can cause systematic complications associated with several systems. Central cognitive impairment and complications of diabetes have become the focus of clinical practice. Progresses on structural imaging and functional imaging of cerebral cognitive impairment in diabetes mellitus, such as MRI, MRS, SPECT, PET and fMRI, were reviewed in this article. Copyright © 2013 by the Press of Chinese Journal of Medical Imaging Technology.

Zeng R.,Chaonan Minsheng Hospital of Shantou | Lin J.,Shantou University | Wu S.,Chaonan Minsheng Hospital of Shantou | Chen L.,Chaonan Minsheng Hospital of Shantou | And 4 more authors.
Archives of Gerontology and Geriatrics | Year: 2015

Objectives: To investigate the effect of a 12-week balance training program, combined TCST, on balance activity and aerobic capacity in patients with hip osteoarthritis. Methods: Single-blind randomized grouping cohort study was conducted at our hospital from December 2008 to December 2011. A total of 81 patients aged from 60 to 69 years old diagnosed with end-stage hip osteoarthritis were recruited. They were randomly divided into two groups: training group (TG) and control group (CG). Participants in TG should do the TCST program under family's supervision for 12 weeks. Parameters including WOMAC score, 6. min walk test, stand up, walk test, situation of the hip mobility were compared between TG and CG by one-way ANOVA. Results: There was no significant difference of baseline characteristics between these two groups (. P>. 0.05). Participants in TG could complete 87.1% of movements of TCST. After training, the distance of 6-min walk was obviously increased from 409.59. ±. 51.31. m to 478.10. ±. 52.46. m (. P<. 0.01), and the time for up and go was significantly shorten from 18.53. ±. 3.90. s to 14.61. ±. 2.60. s (. P<. 0.01), and self-reported functional status scores evaluated by WOMAC was improved from 40.97. ±. 5.65 to 36.28. ±. 5.11 (. P<. 0.01). However, there were no significant changes in pain WOMAC and side hip motion. Conclusion: The 12-week TCST program have good adherence, and can effectively improve balance and aerobic capacity status in patients with end-stage osteoarthritis, while this training can not effectively alleviate the pain and improve hip motion of patients. Hence, further THA is necessary to solve the problems. Practice: Patients with osteoarthritis can do this training program under family's supervision. Implications: Providing a good advice on rehabilitation for patients preparing to do THA. © 2014 Elsevier Ireland Ltd.

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