Changshu No 1 Peoples Hospital

Changshu, China

Changshu No 1 Peoples Hospital

Changshu, China
SEARCH FILTERS
Time filter
Source Type

Chou Y.,Changshu Institute of Technology | Xu B.,Changshu Institute of Technology | Zhang R.,Changshu Institute of Technology | Feng Y.,Changshu Institute of Technology | Jin Y.,Changshu No 1 Peoples Hospital
2016 International Conference on Control, Automation and Information Sciences, ICCAIS 2016 | Year: 2016

The signal to noise ratio (SNR) of dynamic pulse signal is time-varying, which influence the results of common used filtering methods. On the basis of integer-coefficients digital filter, in this study, we proposed a new approach can adjust the parameters of filter by the smooth degree of pulse signal. Moreover, the proposed method and three common used filtering methods: integer-coefficients digital filter, empirical mode decomposition) (EMD) filter and morphological filter are employed to suppress the noise and interference in the simulated and measured pulse signals. The results show that the proposed method can suppress the noise and interference of pulse signal effectively and can be used in dynamic pulse signal filtering. © 2016 IEEE.


Lu Q.,Shanghai JiaoTong University | Zou W.,Nanjing Medical University | Chen B.,Changshu No 1 Peoples Hospital | Zou C.,Shanghai JiaoTong University | And 2 more authors.
Graefe's Archive for Clinical and Experimental Ophthalmology | Year: 2016

Purpose: To investigate the relationship between angiopoietin-like protein 4 (ANGPTL-4) and vascular endothelial growth factor (VEGF) in the serum and vitreous of eyes in patients with proliferative diabetic retinopathy (PDR). Methods: Thirty-five eyes of 35 patients with PDR, 20 eyes of 20 patients with non-proliferative diabetic retinopathy, 20 eyes of 20 patients with diabetes but no diabetic retinopathy, and 14 eyes of 14 nondiabetic patients with an idiopathic macular hole (IMH) were recruited from Shanghai First People’s Hospital. The ANGPTL-4 and VEGF concentrations were determined using enzyme-linked immunosorbent assays. Group means were compared using one-way analysis of variance with GraphPad Prism 4.0 and SPSS ver. 17.0. The research followed the tenets of the Declaration of Helsinki. Results: The ANGPTL-4 and VEGF levels were significantly higher in the vitreous and serum of patients with PDR compared with patients with IMH. There were significant correlations between the ANGPTL-4 and VEGF levels in the vitreous and serum of patients with PDR. The vitreous and serum ANGPTL-4 levels were also significantly correlated in patients with PDR. The ANGPTL-4 in both the vitreous and serum correlated with the serum triglyceride and high-density lipoprotein cholesterol levels. Conclusions: The ANGPTL-4 levels were markedly elevated and the ANGPTL-4 expression was directly correlated with the VEGF expression in the vitreous and serum of patients with PDR. The vitreous and serum ANGPTL-4 levels were also significantly correlated with serum lipids in patients with PDR. Our results suggest that the ANGPTL-4 may be used as a new therapeutic target for the treatment of PDR. © 2015, Springer-Verlag Berlin Heidelberg.


PubMed | Nanjing Medical University, Changshu No 1 Peoples Hospital and Shanghai JiaoTong University
Type: Journal Article | Journal: Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie | Year: 2016

To investigate the relationship between angiopoietin-like protein 4 (ANGPTL-4) and vascular endothelial growth factor (VEGF) in the serum and vitreous of eyes in patients with proliferative diabetic retinopathy (PDR).Thirty-five eyes of 35 patients with PDR, 20 eyes of 20 patients with non-proliferative diabetic retinopathy, 20 eyes of 20 patients with diabetes but no diabetic retinopathy, and 14 eyes of 14 nondiabetic patients with an idiopathic macular hole (IMH) were recruited from Shanghai First Peoples Hospital. The ANGPTL-4 and VEGF concentrations were determined using enzyme-linked immunosorbent assays. Group means were compared using one-way analysis of variance with GraphPad Prism 4.0 and SPSS ver. 17.0. The research followed the tenets of the Declaration of Helsinki.The ANGPTL-4 and VEGF levels were significantly higher in the vitreous and serum of patients with PDR compared with patients with IMH. There were significant correlations between the ANGPTL-4 and VEGF levels in the vitreous and serum of patients with PDR. The vitreous and serum ANGPTL-4 levels were also significantly correlated in patients with PDR. The ANGPTL-4 in both the vitreous and serum correlated with the serum triglyceride and high-density lipoprotein cholesterol levels.The ANGPTL-4 levels were markedly elevated and the ANGPTL-4 expression was directly correlated with the VEGF expression in the vitreous and serum of patients with PDR. The vitreous and serum ANGPTL-4 levels were also significantly correlated with serum lipids in patients with PDR. Our results suggest that the ANGPTL-4 may be used as a new therapeutic target for the treatment of PDR.


PubMed | Changshu No 1 Peoples Hospital, Taixing Chinese Medicine Hospital and Soochow University of China
Type: Journal Article | Journal: Inflammation research : official journal of the European Histamine Research Society ... [et al.] | Year: 2016

Nuclear factor-kappa B (NF-B) has multiple physiological and pathological functions. The role of NF-B can be protective or destructive. We aim to investigate the biphasic activation of NF-B in brain after subarachnoid hemorrhage (SAH).Eighty male New Zealand rabbits are assigned to control, SAH, vehicle, and pyrrolidine dithiocarbamate (PDTC) groups.PDTC (3mg/kg, dissolved in saline) was injected into cisterna magna.Immunofluorescence and electrophoretic mobility shift assay experiments were performed to assess the activation of NF-B. The levels of inflammatory and apoptosis mediators were detected by ELISA and real-time polymerase chain reaction. Nissl and immunofluorescent stain was performed to evaluate neuron injury.NF-B activity in the brain cortex showed two peaks after SAH. Inflammatory mediators exhibited similar time course. PDTC could significantly inhibit the NF-B activity and inflammatory mediators. Suppressing the early NF-B activity significantly decreased neuron injury, while inhibiting the late one could statistically increase neuron injury.The biphasic NF-B activation in the brain cortex after SAH played a decisive role on neuronal fate through the inflammatory signaling pathway. The early NF-B activity contributed to neuron damage after SAH. Nevertheless, the late activated NF-B may serve as a protector.


Lin N.,Zhengzhou University | Wei T.,Henan Institute of Engineering | Xia K.,Changshu No 1 Peoples Hospital | Cai J.,Changshu No 1 Peoples Hospital | Fan H.,Changshu No 1 Peoples Hospital
Journal of Computational Information Systems | Year: 2015

Large dynamic networks are ubiquitous in today's web environment. The big volume and quick changing of structure make it even more difficult to analyze the transitivity of the underlined network. In order to solve this problem, we proposed a sampling method to analyze the transitivity of dynamic networks. Firstly, we defined transitivity in the dynamic network setting. Secondly, we proposed a dynamic network streaming representative sub-graph sampling algorithm. Finally, we gave a triangle counting update algorithm in such a representative sub-graph, and unbiased network transitivity index estimation. Experiments on two real-life network datasets show that, the proposed method is more effective and efficient than related works. ©, 2015, Binary Information Press. All right reserved.


Lu Z.-F.,Soochow University of China | Fu Y.,Changshu No 1 Peoples Hospital | Cheng M.-H.,Soochow University of China | Mao Y.-T.,Soochow University of China | And 4 more authors.
International Journal of Clinical and Experimental Medicine | Year: 2016

Objective: To compare treatment of femoral shaft fractures using traction bed assisted closed reduction (CR) or conventional open reduction (OR) for intramedullary nail fixation. Methods: The study group consisted of 126 patients with femoral shaft fractures who were treated via intramedullary nail fixation from July 2009 to May 2013. Traction bed assisted CR was adopted in 71 patients, while OR was performed in 55 cases. Data regarding surgery duration, intraoperative blood loss, complications and recovery of postoperative hip and knee function were abstracted and analyzed. Results: In patients with non-comminuted fractures, no significant differences were observed between the CR and OR groups in operation time (P = 0.560) or blood loss (P = 0.739). However, in patients with comminuted fractures, operation time (P = 0.024) and blood loss (P = 0.008) were significantly reduced in the table traction group when compared with the OR group. All patients in the CR group had prolonged positioning time (P = 0.000), but no statistically significant differences were found between the open and CR groups in the function of the hip (P = 0.058) or knee (P = 0.625) of the injured limb. Conclusions: Treatment of comminuted femoral shaft fractures using traction bed assisted CR during intramedullary nail fixation had the advantages of reduced surgical time and less intraoperative blood loss when compared with conventional OR. © 2016, E-Century Publishing Corporation. All rights reserved.


Jin Y.,Changshu Institute of Technology | Xia K.,Changshu No 1 Peoples Hospital | Ren X.,Changshu No 1 Peoples Hospital | Cai J.,Changshu No 1 Peoples Hospital | Fan H.,Changshu No 1 Peoples Hospital
Journal of Sensors | Year: 2014

In mobile Internet of Things, there are many challenges, including sensing technology of sensors, how and when to join cooperative transmission, and how to select the cooperative sensors. To address these problems, we studied the combination forecasting based on the multilevel sensing technology of sensors, building upon which we proposed the adaptive opportunistic cooperative control mechanism based on the threshold values such as activity probability, distance, transmitting power, and number of relay sensors, in consideration of signal to noise ratio and outage probability. More importantly, the relay sensors would do self-test real time in order to judge whether to join the cooperative transmission, for maintaining the optimal cooperative transmission state with high performance. The mathematical analyses results show that the proposed adaptive opportunistic cooperative control approach could perform better in terms of throughput ratio, packet error rate and delay, and energy efficiency, compared with the direct transmission and opportunistic cooperative approaches. Copyright © 2014 Yong Jin et al.


PubMed | Changshu No 1 Peoples Hospital and Soochow University of China
Type: Journal Article | Journal: Neurotoxicity research | Year: 2016

The importance and function of serum uric acid (UA) levels in patients with cardiovascular disease or stroke are unclear. We sought to evaluate the appropriate UA levels for stroke patients and the association between endogenous UA levels and clinical outcomes in acute ischemic stroke (AIS) patients, particularly regarding the possible interaction between gender and UA levels with respect to AIS prognosis. We examined 303 patients who had an onset of ischemic stroke within 48 h. Of those, 101 patients received thrombolytic treatment. Serum UA (mol/L) levels were measured the second morning after admission. Patient prognosis was evaluated 90 days after clinical onset by modified Rankin Scale. Patients were divided into four groups according to serum UA quartiles. A binary multivariate logistic regression model was used to assess clinical relevance in regard to functional outcome and endogenous UA levels. Analysis of subgroups by gender and normal glomerular filtration rate were also been done. Poor functional outcome was associated with older age, history of atrial fibrillation, or higher baseline National Institutes of Health Stroke Scale scores. After adjustment for potential confounders, patients with higher UA levels (>380 mol/L) or lower UA levels (250 mol/L) were 2-3 times more likely to have a poor outcome (OR 2.95, 95% CI 1.14-7.61; OR 2.78, 95% CI 1.02-7.58, respectively) compared to the baseline group (UA level 316-380 mol/L). The same results were observed in thrombolyzed patients. Patients with high and low UA levels were 9-18 times more likely to having poor outcomes compared to the baseline group (UA level: 316-380 mol/L; OR 18.50, 95% CI: 2.041-167.67; OR 9.66, 95% CI 1.42-65.88, respectively). In men, patients with high UA levels were 6 times more likely to have poor outcomes compared to the baseline group (UA level: 279-334 mol/L; OR 6.10, 95% CI 1.62-22.93). However, female patients with UA level 271-337 mol/L were seven times more likely to perform badly compared to the baseline group (UA level >337 mol/L, OR 7.06, 95% CI 1.00-49.81). Serum UA levels in an appropriate range were associated with better outcome in patients with AIS but may be harmful when too high or too low. The association of UA levels with AIS prognosis differed in male and female patients, which highlights the necessity of stratifying by gender in investigations of cerebrovascular risk factors.


Chen T.,Changshu No 1 Peoples Hospital | Chen H.,Changshu No 1 Peoples Hospital | Wang Y.,Changshu No 1 Peoples Hospital | Zhang J.,Changshu No 1 Peoples Hospital
Pharmaceutical Biology | Year: 2016

Context Pueraria lobata (Leguminoseae) shows cytotoxic effects against cancer cells; however, its active components remain unclear. Objective This study investigated the antitumour activity of puerarin 6″-O-xyloside (POS) on the human lung carcinoma A549 cell line. Materials and methods The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay was used to determine the cytotoxicity of POS (at 10, 20 and 40 μM) in vitro, and xenograft nude mice were established to evaluate the antitumour effect of POS (at 40 mg/kg/d) in vivo by 15 days intraperitoneal injection (ip). To explore its mechanism of action, flow cytometry was performed to determine the pro-apoptotic effect of POS (at 10, 20 and 40 μM). Subsequently, the expression of caspase-3, caspase-7, caspase-9, Bcl-2 and Bax in A549 cells were determined. Results POS showed significant cytotoxicity toward A549 cells (p < 0.05) by inducing apoptosis. Treatment with POS significantly upregulated the levels of caspase-3 (p < 0.01), caspase-7 (p < 0.01), caspase-9 (p < 0.01) and Bax (p < 0.01) in A549 cells, and Bcl-2 was downregulated (p < 0.01). Additionally, the in vivo animal study showed that POS significantly inhibited tumour growth in A549 cells (p < 0.01). Conclusion Our study demonstrated the POS has significant antitumour activities. The mechanisms are related to increased levels of caspase-3, caspase-7, caspase-9 and Bax, and reduced levels Bcl-2. © 2016 Taylor & Francis

Loading Changshu No 1 Peoples Hospital collaborators
Loading Changshu No 1 Peoples Hospital collaborators