Hengyang, China

Changsha Medical University

www.csmu.edu.cn
Hengyang, China

Changsha Medical UniversityCollege , China's governmental medical university for undergraduates,was founded by the famous educator Binsheng He in 1989. It is situated in Changsha, capital of Hunan Province and was upgraded to a medical university for undergraduates in 2005 by Ministry of Education. CSMU is under the jurisdiction of Hunan People's Government and the professional guidance of the Department of Public Health of the government. CSMU is listed in WHO's World Directory of Medical Schools and is welcoming students from all over the world. Wikipedia.

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Li H.-J.,Central University of Finance and Economics | Xiang J.,Changsha Medical University
Journal of Intelligent and Fuzzy Systems | Year: 2017

Detecting fuzzy network communities in directed network is a classic and very difficult task in the field of complex network analysis, principally for its applications in domains such as social or biological networks analysis. Present techniques rely heavily on network topology, which cannot provide a lot of important information, such as module correlation and hierarchical structure. In this paper, we present a new fuzzy community detection method, which is able to find fuzzy communities in directed line graphs by maximizing likelihood function. Firstly, the directed node graph is transformed to a new type directed line graph, and the direction and weight of line graph are defined. Then, the community unit consists of membership and correlation information is defined in the line graph. Specifically, there are two main contributions of this method: 1) to adequately characterize the community structure, the node and module correlation with different granularity can be calculated; 2) based on the membership and correlation information, we can extract the multiplex patterns between communities, according to different domain requirements. Furthermore, we are able to map the link community configuration to the optimal situation dynamically by maximizing the likelihood function with rigorous mathematical proof. Based on the spectral analysis of the Markovian transition matrix, a mathematical theory is provided to identify the optimum number of network communities, and to analyze the stability of the community structure. Extensive simulations using both synthetic and real-world benchmark networks are performed to verify the algorithmic performance. © 2017-IOS Press and the authors. All rights reserved.


Bao M.-H.,Central South University | Bao M.-H.,Changsha Medical University | Zhang Y.-W.,Central South University | Zhou H.-H.,Central South University
Journal of Ethnopharmacology | Year: 2013

Paeonol is an active compound isolated from traditional Chinese medicine, and has been shown to have anti-atherosclerosis, anti-inflammatory, antioxidant effects. The present investigation was undertaken to determine the suppression effects of paeonol on oxidized low-density lipoprotein (ox-LDL) induced endothelial cell line HUVEC apoptosis and to uncover some of the underlying mechanisms of these effects. Cell viability and lactate dehydrogenase (LDH) were measured to evaluate the cell injuries. Apoptosis was evaluated by Hoechst 33342 staining and flow cytometry. Intracellular reactive oxygen species (ROS) generation was detected by 2′,7′-dichlorofluorescein diacetate (DCFH-DA). Real-time PCR was used to confirm the expression of LOX-1 mRNA. Western blotting was used to evaluate the protein expression of LOX-1 and Bcl-2, as well as caspase-3 cleavage, p38-mitogen-activated protein kinase (p38MAPK) phosphorylation. NF-κB nuclear translocation was detected by Western blotting and immunofluorescence. Caspase-3 activity was measured using a colorimetric protease assay kit. The results showed that ox-LDL significantly decreased cell viability and increased the LDH release, as well as the apoptotic rate (P<0.01). Pre-treatment of paeonol resulted in remarkable increase of cell viability, decrease of LDH release and cell apoptosis in a concentration-dependent manner. Besides, ox-LDL caused the up-regulation of LOX-1, the down-regulation of Bcl-2, the phosphorylation of p38MAPK, the translocation of NF-κB and the activation of caspase-3. Paeonol pre-treatment reversed these effects introduced by ox-LDL. Moreover, paeonol also showed its inhibition effects on ox-LDL induced ROS overproduction. These results indicate the preventive effects of paeonol on ox-LDL induced endothelial cell apoptosis. The effects might, at least partly, be obtained via inhibition of LOX-1-ROS- p38MAPK-NF-κB signaling pathway. © 2013 Elsevier Ireland Ltd.


Luo H.,Changsha Medical University | Han L.,Changsha Medical University | Tian S.,University of South China
Neuroscience Letters | Year: 2014

There is increasing evidence that nitric oxide may be involved in learning and memory. However, there remain comparatively few studies that have explored the relationship between nitric oxide signaling and fear extinction, an inhibitory learning model. In the present study, we tested the effects of nitric oxide synthase inhibitor l-NAME on three tone fear extinction tasks in rats. In task 1, rats received fear conditioning, extinction training and extinction test in the same context (AAA design). In task 2, rats received fear conditioning in context A, extinction training in context B and extinction test in context A (ABA design). In task 3, rats received fear conditioning in context A, extinction training and extinction test in context B (ABB design). l-NAME (10, 20 and 40. mg/kg) was injected intraperitoneally 30. min prior to extinction training in each task. Percent of time spent freezing was used to measure conditioned fear response. We found that l-NAME administrations had no effect on freezing in task 1 and 2 but produced a dose-dependent increase in task 3. Further results indicated that the increased freezing in task 3 was not attributed to state-dependency effects or nonspecific changes of locomotor activity that followed l-NAME injection. These results showed that l-NAME produced a task-dependent impairment of fear extinction, and implied that nitric oxide signaling was involved in memory process of certain extinction tasks. © 2014 Elsevier Ireland Ltd.


Peng L.,Changsha Medical University | Cao Z.,Hunan University | Liu L.,Changsha Medical University
Journal of Computational and Theoretical Nanoscience | Year: 2013

We presented a network comparison method for finding the conservative interaction regions in the across-species protein interaction networks (PINs). In the first part, firstly, we made use of the correlated matrix to represent the PINs. Then we standardized the matrix and changed it into a unique representation to facilitate to judge whether the subgraphs is isomorphic. Subsequently, we proposed a network comparison algorithm based on the correlated matrix, edge-betweenness and the maximal frequent subgraphs mining. We used the tag graphs library composed of the multiple across-species PINs as input data and mined the maximal frequent subgraphs. In the second part, we clustered and merged the similar but different and duplicate locally regions according to the similarity between them and the principle of single linkage clustering. In the end we analysed the resulting subgraphs and predicted the conservative interaction regions. The results showed the network comparison algorithm based on mining the frequent subgraphs can be successfully applied to discover the conservative interaction regions, that is to say, we can find the functional complexes. Furthermore, we can conclude the protein interactions existing in one species will be able to exist in the other species when the occurrences of the conservative regions meet or exceed the threshold of minimum support. Copyright © 2013 American Scientific Publishers All rights reserved.


Yang K.,Changsha Medical University | Yang K.,Hunan University | Zeng M.,Changsha Medical University
New Journal of Chemistry | Year: 2013

A novel multiresponsive hydrogel based on polyacrylamide functionalized with thymine derivatives has been demonstrated. In this study, thymines are grafted to the polyacrylamide chains by introducing thymines to the acrylamide precursors. Based on the photodimerization/cleavage of grafted thymines, the reversible sol-gel transition can be operated by alternate irradiation with 365 and 240 nm UV light. More importantly, thymine-functionalized polyacrylamide can combine with each other by the formation of a thymine(T)-Hg2+- thymine(T) complex to form a hydrogel in the presence of Hg2+. The formed hydrogel can gradually dissolve with the dissociation of the T-Hg 2+-T complex by a series of external stimuli such as pH, thymine and thiol compounds. Subsequently, Ru(bipy)3 2+ dye-doped silica nanoparticles (FSiNPs) are selected as model guests and loaded into hydrogel to demonstrate multiresponsive controlled release behavior. Moreover, the FSiNPs loaded with Hg2+-cross-linked hydrogel can be employed as a sensor for the detection of cysteine biomolecule. These results indicate that thymine-functionalized polyacrylamide can not only realize a multiresponsive gel-sol transition but also has a promising application in the field of controlled release and biochemical analysis. © 2013 The Royal Society of Chemistry and the Centre National de la Recherche Scientifique.


Yang J.,Hunan City University | Li D.,Hainan Normal University | Peng L.,Changsha Medical University | Long K.,Hunan City University
Journal of Computational and Theoretical Nanoscience | Year: 2013

Based on the classification of the amino acid, the paper presents a mathematic representation of protein sequences, and then obtains a M matrix on the basis of mathematic expression. Then we computed the mathematic invariable according to the M matrix, namely five-dimensional feature vector. According to the angle between two vectors, we analyzed the similarity of 13 kinds of the original sequence of coronavirus N protein. With the software PHYLIP, we create a phylogenetic tree structure and compare the experimental results with the traditional one. The experimental results show that the mathematical model of this method is simple and have low computational complexity and better results. Such method of mathematic representation and similarity analysis of protein sequences is a new impetus for the comparison of protein sequences. Copyright © 2013 American Scientific Publishers.


Bao M.-H.,Changsha Medical University | Dai W.,Central South University | Li Y.-J.,Central South University | Hu C.-P.,Central South University
Canadian Journal of Physiology and Pharmacology | Year: 2011

It is proposed that myocardial cell apoptosis causes ventricular remodeling and heart failure. The aim of the present study was to determine the effects of rutaecarpine (Rut) on hypoxia-reoxygenation (H-R)-induced apoptosis in myocardial cell line H9c2, as well as the underlying mechanisms. Cultured H9c2 cells were exposed to hypoxia for 24 h, followed by 12 h reoxygenation. Rut (in concentrations of 0.1, 1, and 10 μmol/L) was added 1 h prior to H-R. Cell viability and lactate dehydrogenase were measured to evaluate the cell injuries. Apoptosis was evaluated by Hoechst 33258 staining and flow cytometry. NADPH oxidase activity was measured by assay kit; intracellular reactive oxygen species (ROS) generation was detected by 2′,7′-dichlorofluorescein diacetate; and Nox2, Nox4, and p47 phox mRNA and protein expression were analyzed by real-time PCR and Western blotting, respectively. The results showed that H-R significantly decreased cell viability and increased the lactate dehydrogenase release, as well as the apoptotic rate, concomitantly with enhanced NADPH oxidase activity. H-R also upregulated mRNA and protein expressions of Nox2, Nox4, and p47 phox and increased ROS production. Treatment with Rut markedly reversed these effects introduced by H-R. These results suggest that the protective effects of Rut against H-R-induced myocardial cell injury and apoptosis might, at least partly, be due to the inhibition of the NADPH oxidase - ROS pathway.


Xiao Z.,Changsha Medical University
Communications in Computer and Information Science | Year: 2011

Culture is an inseparable element of the sociolinguistic approach to language and language learning. A language cannot be taught and learned without coming to grips with its cultural content. It is well known that learning a foreign language is not only a process of understanding and using only the linguistic, but also the sociolinguistic level of cross-cultural communication as well. An inseparable element of the sociolinguistic approach to language and language learning is culture. A language cannot be taught without coming to grips with its cultural content. This eclectic paradigm entails designing learning resources that allow flexibility and variability while enabling students to learn through interaction with materials and other learners. © 2011 Springer-Verlag Berlin Heidelberg.


Qian M.,Changsha Medical University
Communications in Computer and Information Science | Year: 2011

Blended Learning modes create an ideal teaching environment and atmosphere by making good use of modern information and technology. As a result, the advantages of multimedia internet learning and regular classroom teaching are integrated well, bringing the teacher's guiding function (guidance, inspiring and monitoring) in teaching into full play and reflecting the student's subject position (initiative, enthusiasm and creativity) in learning. And the teaching concept "organic combination of the teacher's guiding function and the student's subject position" is actualized fully. © 2011 Springer-Verlag Berlin Heidelberg.


Luo H.-Q.,Changsha Medical University | Han L.,Changsha Medical University | Jiang Y.,Changsha Medical University
Asian Pacific Journal of Cancer Prevention | Year: 2014

Background: A meta-analysis was performed to examine the benefit/risk ratio for the addition of anti-HER MoAbs to chemotherapy in patients with advanced gastric and gastroesophageal cancer from six randomized phase II/III trials. Materials and Methods: We searched relative trials from Pubmed, EMBASE, Cochrane library databases, China National Knowledge Infrastructure databases, Google Scholar and the NIH ClinicalTrials. Primary outcomes were overall response rate (ORR), progression-free survival (PFS), overall survival (OS). Secondary outcomes were toxicities. All analyses were performed using STATA 12.0. Results: This meta-analysis included six randomized controlled trials (RCTs) with 2, 297 patients and we demonstrated that the anti-HER MoAbs arm did have a positive effect on ORR in the anti-HER MoAbs arm (OR 1.28, 95% CI 1.00-1.64, p=0.01). There was an increasing benefit regarding OS (HR 0.74, 95% CI 0.60-0.88, p<0.05) and PFS (HR 0.72, 95% CI 0.60-0.84, p<0.05) in the anti-HER2 subgroup, but a reduction of OS (HR 1.11, 95% CI 0.87-1.36, p<0.05) and PFS (HR 1.13, 95% CI 0.98 -1.28, P<0.05) in anti-EGFR subgroup. Some grade 3-4 toxicity had a significantly higher incidence in the anti-HER MoAbs arm. There was no significant publication bias for all endpoints. Conclusions: The addition of trstuzumab MoAb to chemotherapy for gastric and gastroesophageal cancer significantly improved outcome of OS and PFS endpoints, while other MoAbs led to no improvement in results. Some adverse events were increased in anti-HER MoAbs arm compared with the control.

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