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Bian L.,Shanghai University | Lu X.,Changning District Central Hospital | Xu J.,Shanghai University | Chen J.,Shanghai University | And 6 more authors.
Journal of Fluorine Chemistry | Year: 2013

The synthesis of 2-perfluoroalkylated benzoxazolines and benzothiazolines was easily achieved under mild conditions in high yields and purity. The protocol uses readily available methyl 2-perfluoroalkynoates as fluorine-containing building block, and furnished the expected product in good to excellent yields in MeOH under reflux for 10 h. This novel synthetic protocol is efficient and general. A plausible mechanism for this process is proposed. © 2013 Elsevier B.V. All rights reserved.


Han J.,Shanghai University | Li L.,Changning District Central Hospital | Shen Y.,Shanghai University | Chen J.,Shanghai University | And 6 more authors.
European Journal of Organic Chemistry | Year: 2013

One-pot, two-step cyclization of o-aminophenyl ketones 1 and methyl perfluoroalk-2-ynoates 2 takes place in the presence of copper(I) as catalyst and diisopropylethylamine as base, leading to 2-perfluoroalkylated quinolines. Compared with previous methods that have been used to generate quinoline skeletons, this technique uses inexpensive copper salt as catalyst, methyl perfluoroalk-2-ynoate as fluorinated building block and proceeds smoothly under mild conditions, which makes the transformation both sustainable and practical. Copper(I)-catalyzed, one-pot, two-step cyclization of o-aminophenyl ketones 1 and methyl perfluoroalk-2-ynoates 2 in the presence of diisopropylethylamine leading to 2-perfluoroalkylated quinolines 3 proceeds smoothly under mild conditions. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.


Zhu T.-q.,Shanghai JiaoTong University | Zhang Q.,Shanghai JiaoTong University | Ding F.-h.,Shanghai JiaoTong University | Qiu J.-p.,Gong Li Hospital | And 8 more authors.
Chinese Medical Journal | Year: 2013

Background No randomized trial has been performed to compare the efficacy of an intracoronary bolus of tirofiban versus urokinase during primary percutaneous coronary intervention (PCI). We investigated whether the effects of adjunctive therapy with an intracoronary bolus of urokinase was noninferior to the effects of an intracoronary bolus of tirofiban in patients with ST-elevation myocardial infarction (STEMI) undergoing PCI. Methods A total of 490 patients with acute STEMI undergoing primary PCI were randomized to an intracoronary bolus of tirofiban (10 μg/kg; n=247) or urokinase (250 kU/20 ml; n=243). Serum levels of P-selectin, von Willebrand factor (vWF), CD40 ligand (CD40L), and serum amyloid A (SAA) in the coronary sinus were measured before and after intracoronary drug administration. The primary endpoint was the rate of complete (≥70%) ST-segment resolution (STR) at 90 minutes after intervention, and the noninferiority margin was set to 15%. Results In the intention-to-treat analysis, complete STR was achieved in 54.4% of patients treated with an intracoronary bolus of urokinase and in 60.6% of those treated with an intracoronary bolus of tirofiban (adjusted difference: -7.0%; 95% confidence interval: -15.7% to 1.8%). The corrected TIMI frame count of the infarct-related artery was lower, left ventricular ejection fraction was higher, and the 6-month major adverse cardiac event-free survival tended to be better in the intracoronary tirofiban group. An intracoronary bolus of tirofiban resulted in lower levels of P-selectin, vWF, CD40L, and SAA in the coronary sinus compared with an intracoronary bolus of urokinase after primary PCI (P<0.05). Conclusions An intracoronary bolus of urokinase as an adjunct to primary PCI for acute STEMI is not equally effective to an intracoronary bolus of tirofiban with respect to improvement in myocardial reperfusion assessed by STR. This may be caused by less reduction in coronary circulatory platelet activation and inflammation.


Zuo X.,Fudan University | Zuo X.,Tongji University | Zuo X.,Changning District Central Hospital | Shen A.,Tongji University | Chen M.,Changning District Central Hospital
Australian and New Zealand Journal of Obstetrics and Gynaecology | Year: 2012

Aims To analyse the optimal laparoscopic surgical techniques for the treatment of interstitial pregnancy to minimise bleeding during the operative procedure and the safety of the subsequent pregnancy. Methods Advanced bipolar coagulator was used to achieve haemostasis. Results The mean gestational age was 55 ± 5.1 days. All 17 women with an interstitial pregnancy were successfully treated by laparoscopic surgery without any complication. No surgery was converted to laparotomy. The mean pre-operative beta-human chorionic gonadotropin (β-hCG) serum concentration was 14 696 ± 11 705 mIU/mL. This value decreased to 1911 ± 1769 mIU/mL at 3-day post-operation. Among women who underwent laparoscopic surgery, a cornual resection was performed in 16 (94.1%) cases. One (5.8%) woman underwent a laparoscopic evacuation of the conceptus and received a local injection of 10 mg methotrexate. The volume of blood loss was <25 mL in 16 cases. However, one woman experienced a rupture at the beginning of the operation and lost 250 mL of blood. The mean hospital stay was 4.5 days. Four of the nine women who chose to retain their reproductive function had subsequent normal pregnancies, but all received an elective caesarean delivery prior to labour. Conclusions The laparoscopic management of women with unruptured interstitial pregnancy can frequently be performed without haemorrhage or complication using advanced bipolar coagulation. The small sample of successful subsequent pregnancies demonstrates the safety and effectiveness of this technique, but this finding should be confirmed by further investigations. © 2012 The Royal Australian and New Zealand College of Obstetricians and Gynaecologists.


Lin X.L.,Changning District Central Hospital
Zhonghua fu chan ke za zhi | Year: 2011

To investigate the relationship between vaginal and intestinal candida in patients with vulvovaginal candidiasis by using microbiological and molecular methods. The samples of vaginal discharge and anal swabs were collected from 148 cases with vulvovaginal candidiasis, followed by fungal culture, identification, purification and genome DNA extraction. The genome sequences from respective locations were aligned and typed according to their homology analyzed by internal transcribed spacer (ITS) PCR and random amplified polymorphic DNA (RAPD) PCR. Patients with vulvovaginal infection or those with infections in intestine and vulvovagina were pooled respectively, while the recurrent incidences after local anti-fungal treatments were analyzed. Candida albicans is the dominant pathogen in 148 cases with vulvovaginal candidiasis (91.9%, 136/148); 33.1% (49/148) of patients with vulvovaginal candidiasis were infected in both intestine and vulvovagina. While 92% (22/24) of patients with intestinal and vaginal candida infection showed high homology. The recurrent rate of patients with vulvovaginal candidiasis complicated with concurrent intestinal candida infection (7/14) was significantly higher than that of solo vaginal infected patients [21% (6/29)] after vaginal treatment (P<0.05). The infection of vulvovaginal candidiasis is highly associated with the concurrent infection of intestinal candida. The recurrent rate is high in patients with vulvovaginal candidiasis with concurrent infection of intestinal candida after vaginal treatment. The general management to those patients infected by both vulvovaginal and intestinal candida is necessary in reducing the recurrence of the disease.


Qian M.,Changning District Central Hospital | Zhang Y.-M.,Changning District Central Hospital | Sun J.,Changning District Central Hospital
Journal of Clinical Dermatology | Year: 2012

Objective: To investigate the efficacy and safety treatment with mizolastine for acute urticaria, and assess the effect on quality of life. Methods: All of the patients with acute urticaria were randomly assigned into two groups: mizolastine treatment group (108 cases) and cetirizine treatment group (105 cases). And the patients were taken mizolastine or cetirizine 10 mg daily for 14 days. The severity of acute urticaria in patients was rated according to UAS (uticaria activity score). Dermatology life quality index (DLQI) questionnaire scores were used and then statistical analysis was made. Results: After 7 days, there were significant differences in the UAS and DLQI among the two groups. The UAS and DLQI scores significantly improved in the mizolastine group. No severe adverse reactions were observed. Conclusion: Mizolastine can not only decrease UAS scores but also improve the DLQI in patients with acute urticaria.


Li Y.,Changning District Central Hospital | Xiao Y.-T.,Changning District Central Hospital | Min Y.-J.,Changning District Central Hospital | Liu Q.,Changning District Central Hospital | And 2 more authors.
International Journal of Ophthalmology | Year: 2010

AIM: To observe the application value of fundus pre-set lens examination in preoperative fundus examination and predicting postoperative best-corrected visual acuity (BCVA) of cataract. METHODS: A total of 671 patients 874 eyes with cataract were observed and all the eyes were divided into 3 groups according to lens opacities degree; group A: grade 3 or lower; group B: grade 4; group C: grade 5. Before phacoemulsification, ocular fundus was observed respectively by direct ophthalmoscope and fundus pre-set lens(+90D). We tried to forecast the postoperative BCVA by fundus examination combining lens opacities degree and preoperative BCVA analysis. Ocular fundus and BCVA were reexamined in two weeks after phacoemulsification. Compare the detection rate of preoperative ocular fundus diseases and coincidence rate of predictive postoperative BCVA by direct ophthalmoscope and fundus pre-set lens. Pearson's chi-square test was used in the data statistics. RESULTS: The detection rate of preoperative ocular fundus diseases by direct ophthalmoscope; group A: 96.8% (30/31); group B: 69.5% (66/95); group C: 35.3% (18/51), coincidence rate of predictive postoperative BCVA by direct ophthalmoscope: group A: 94.8% (163/172); group B: 87.4% (416/476); group C: 60.6% (137/226). The detection rate of preoperative ocular fundus diseases by fundus pre-set lens: group A: 100% (31/31); group B: 93.7% (89/95); group C: 84.3% (43/51) coincidence rate of predictive postoperative BCVA by fundus pre-set lens: group A: 95.9%(165/172); group B: 92.0%(438/476); group C: 76.1% (172/226). The detection rate of preoperative ocular fundus diseases and coincidence rate of predictive postoperative BCVA by fundus pre-set lens were significantly higher than by direct ophthalmoscope in group B and group C. The total detection rate of preoperative ocular fundus diseases by fundus pre-set lens was 92.1% while the coincidence rate of predictive postoperative BCVA was 88.7%. CONCLUSION: The detection rate of preoperative ocular fundus diseases by fundus pre-set lens examination in preoperative examination of cataract is higher than by direct ophthalmoscope. Combined with lens opacities degree and preoperative BCVA analysis, fundus pre-set lens examination can roughly predict post-operative BCVA in patients with cataract in immature stage.


Huang S.,Changning District Central Hospital | Peng W.,Changning District Central Hospital | Zhao W.,Changning District Central Hospital | Sun B.,Changning District Central Hospital | Jiang X.,Changning District Central Hospital
Asian Biomedicine | Year: 2013

Background: Impaired Glucose Regulation (IGR) is a term that refers to blood glucose levels that are higher than the normal range, but lower than Type 2 diabetes mellitus (T2DM). Objective: We aimed to test the role of plasma adiponectin (APN) and plasma C-reactive protein (CRP) in predicting the risk of cardiovascular disease in patients with different degrees of impaired glucose regulation (IGR). Methods: A total of 210 outpatients for physical examination were divided into 4 groups: 42 cases of normal glucose tolerance (NGT), 36 cases of impaired fasting glucose (IFG), 92 cases of impaired glucose tolerance (IGT) and 40 cases of IFG+IGT. Body mass index (BMI), blood pressure, lipids, insulin resistance (homeostasis model assessment, HOMA-IR), APN, CRP and carotid intima-media thickness (CIMT) were measured. Results: In IGT and IFG+ IGT groups, CIMT and CRP were significantly higher, whereas APN was significantly lower compared with IFG and NGT groups (p < 0.05). BMI and HOMA-IR were significantly higher in IGR patients compared with control subjects (p < 0.05). CIMT was positively related to CRP and HOMA-IR and negatively to APN (p < 0.05). Multiple stepwise regression analysis using CIMT as a dependent variable showed that APN and 2hPG were independently risk factors associated with CIMT. Conclusion: Increased CIMT in prediabetes state may in part be explained by lower plasma adiponectin and higher C-reactive protein levels.


Liu W.,Changning District Central Hospital | Yang J.,Changning District Central Hospital | Zhang Y.,Changning District Central Hospital | Shao K.-W.,Changning District Central Hospital | Zhu C.-S.,Changning District Central Hospital
Chinese Journal of Radiology | Year: 2010

Objective: To study the diagnostic value of calcification in differentiating benign and malignant thyroid lesions. Methods: CT images of 318 consecutive patients with pathologically proven thyroid lesions were retrospectively reviewed by two radiologists. The following characteristics of calcification on CT images were evaluated: (1) size (≤ 2 mm indicating microcalcification and > 2 mm or shelly and irregular shape indicating macrocalcification, and both features indicating mixed calcification), (2) number (single or multiple) and (3)location (internal or edge). χ2 test was used for statistical analysis. Results: Of the 318 cases, 48 were diagnosed as malignant (papillary carcinoma 26, follicular carcinoma 7, medullary carcinoma 3 and microcarcinoma 12) and 270 were benign (nodular goiter 36, adenoma 170, nodular goiter with adenoma 38 and adenoma with Hashimoto's thyroiditis 26). Calcification was found in 60 cases (18.9%). Among them 21(papillary carcinoma 12, microcarcinoma 6, follicular carcinoma 2 and medullary carcinoma 1) were malignant(43.8%) and 39(nodular goiter 6, adenoma 13, nodular goiter with adenoma 19 and adenoma with Hashimoto's thyroiditis 1) were benign(14.4%) (P <0.01). Sensitivity and specificity for diagnosing thyroid carcinoma were 43.8% (21/48) and 85.6% (231/270) , respectively. Microcalcification was found in 37 cases (malignant 8, benign 29) and macrocalcification was found in 23 cases (malignant 13, benign 10) (P < 0.01). Sensitivity and specificity of macrocalcification for diagnosing thyroid carcinoma were 61.9% (13/21) and 74.4% (29/39), respectively. Single calcification was found in 31 cases(malignant 13, benign 18) and multiple calcification was found in 29 cases(malignant 8, benign 21) (P > 0.05). Internal calcification was found in 15 cases of malignant lesions(71.4%) and 12 of benign lesions(30.8%); Edge calcification was found in 6 cases of malignant and 27 of benign, (P < 0.01). Sensitivity and specificity of internal calcification for diagnosing thyroid carcinoma were 71.4% (15/21) and 69.2% (27/39), respectively. Conclusion: Internal calcification or(and) macrocalcification of the thyroid lesions may strongly suspect thyroid carcinoma and fine-needle aspiration or surgery should be further performed.


PubMed | Changning District Central Hospital
Type: Journal Article | Journal: Zhonghua fu chan ke za zhi | Year: 2011

To investigate the relationship between vaginal and intestinal candida in patients with vulvovaginal candidiasis by using microbiological and molecular methods.The samples of vaginal discharge and anal swabs were collected from 148 cases with vulvovaginal candidiasis, followed by fungal culture, identification, purification and genome DNA extraction. The genome sequences from respective locations were aligned and typed according to their homology analyzed by internal transcribed spacer (ITS) PCR and random amplified polymorphic DNA (RAPD) PCR. Patients with vulvovaginal infection or those with infections in intestine and vulvovagina were pooled respectively, while the recurrent incidences after local anti-fungal treatments were analyzed.Candida albicans is the dominant pathogen in 148 cases with vulvovaginal candidiasis (91.9%, 136/148); 33.1% (49/148) of patients with vulvovaginal candidiasis were infected in both intestine and vulvovagina. While 92% (22/24) of patients with intestinal and vaginal candida infection showed high homology. The recurrent rate of patients with vulvovaginal candidiasis complicated with concurrent intestinal candida infection (7/14) was significantly higher than that of solo vaginal infected patients [21% (6/29)] after vaginal treatment (P<0.05).The infection of vulvovaginal candidiasis is highly associated with the concurrent infection of intestinal candida. The recurrent rate is high in patients with vulvovaginal candidiasis with concurrent infection of intestinal candida after vaginal treatment. The general management to those patients infected by both vulvovaginal and intestinal candida is necessary in reducing the recurrence of the disease.

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