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Tan Q.,Central South University | Xie L.,Central South University | Xia Y.,Central South University | Zhu Z.,Central South University | And 2 more authors.
Zhongnan Daxue Xuebao (Ziran Kexue Ban)/Journal of Central South University (Science and Technology) | Year: 2015

The wear rate of tunnel boring machine (TBM) disc cutter based on contact pressure and relative slide velocity was built. Then the effect of penetration, cutter radius change and installation radius on disc cutter wear rate was researched, and the prediction method of disc cutter's lifetime was studied. The conclusion was proved by engineering practice. The results show that the point with the maximum wear rate is between the deepest penetration point and breaking forward point. The wear rate of disc cutter increases almost linearly with the installation radius, and it increases with the increase of penetration and the decrease of disc cutter radius, and penetration is the most influential factor of wear rate of disc cutter. ©, 2015, Central South University of Technology. All right reserved.

She J.,Central South University | She J.,Changde Vocational and Technical College | Tang J.,Central South University | Hua M.,Changde Vocational and Technical College | And 2 more authors.
Zhongnan Daxue Xuebao (Ziran Kexue Ban)/Journal of Central South University (Science and Technology) | Year: 2013

The volatile constituents in herbal pair (HP) and its single herbs were detected and analyzed by the method of gas chromatography-mass spectrometry (GC-MS) and alternative moving window factor analysis (AMWFA) and by mass spectrometry library combining retention indices. Then, comparison analysis of common volatile constituents in herbal pair (HP) Fructus Aurantii (FA) -Rhizoma Atractylodis Macrocephalae (RAM) and its single herbs was performed. In total, 47, 46 and 89 volatile chemical components in volatile oil of FA, RAM and its herbal pair FA-RAM were separately determined qualitatively, accounting for 92.64%, 92.29% and 83.10% of total contents of volatile oil in FA, RAM and its herbal pair FA-RAM respectively. The results show that there are 39 common volatile constituents in herbal pair and single herb FA, and 37 common volatile constituents in herbal pair and single herb RAM. The volatile chemical components in herbal pair FA-RAM from single herb and FA from single herb RAM are all about 50%.

She J.-M.,Central South University | She J.-M.,Changde Vocational and Technical College | Zhong M.,Central South University | Liang Y.-Z.,Central South University | And 3 more authors.
Zhongnan Daxue Xuebao (Ziran Kexue Ban)/Journal of Central South University (Science and Technology) | Year: 2011

The volatile constituents were extracted from Ramulus Cinnamomi(RC), Atractylodes macrocephala(AM) and herbal pair(HP) RC-AM by steam distillation. Using gas chromatography-mass spectrometry (GC-MS) combined with heuristic evolving latent projections(HELP), a useful chemometric resolution method which can be used to resolve overlapping peaks in chromatogram, was employed to identify and comparatively analyze the volatile constituents, together with the temperature-programmed retention index for assistant identification. The results show that there are 66, 29 and 55 kinds of constituents of the essential oils being identified respectively from single herb RC, AM and HP-RC-AM, and the relative amount accounts for 94.43%, 95.93% and 96.35 % of the total relative contents in order. There are 4 common volatile constitutions in single herb and HP, and accounting for 13.14% total contents in HP. There are 4 components increasing in HP, while there are 33 and 7 components losing in the single herb CR and AM respectively. The volatile principally components in HP are 2-(2-Methoxyphenoxy)phenol, γ-Selinene and Cinnamaldehyde, et al., and they are mainly from single herb AM. Their relative kinds and amount in HP are not equal to the two single herbs, whose reaction mechanism in HP should be studied further.

He L.,Central South University | Liu G.,Changde Vocational and Technical College | Shi Y.,Changde Vocational and Technical College | Peng X.,Central South University | And 2 more authors.
Pharmacology | Year: 2015

Focal segmental glomerulosclerosis (FSGS) is a specific pattern of chronic renal injury with progressive glomerular scarring. The phenotypic alterations that contribute to FSGS include inflammatory response and oxidative stress. Astaxanthin (ATX) has a broad range of biological functions, particularly antioxidant and anti-inammatory ones. This study was designed to evaluate the renoprotective effect of ATX treatment on Adriamycin-induced FSGS. Methods: In Balb/c mice, Adriamycin nephropathy was induced by Adriamycin (10 mg/kg body weight, diluted in normal saline) via a tail vein on day 0. Then the mice were treated with ATX (50 mg/kg body weight) once daily by oral gavage, again starting on the day of Adriamycin injection and continued for 6 weeks. At 6 weeks, the mice were sacrificed; kidneys and blood samples were collected for further analysis. Results: Animals that underwent intermittent exposure to ATX treatment exhibited significant improvements in renal functional parameters as well as in glomerular and interstitial fibrosis compared to those undergoing saline treatment in FSGS mouse models. ATX treatment exerted anti-inflammatory and antioxidant effects by promoting Nrf2 expression and suppressing renal nucleotide-binding oligomerization domain-like receptor protein 3 inammasome activation. Conclusion: ATX might offer a ray of hope for ameliorating FSGS. © 2015 S. Karger AG, Basel.

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