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Lin G.,Changchun SinoBiomaterials Co. | Cui Y.,CAS Changchun Institute of Applied Chemistry | Cui Y.,Changchun SinoBiomaterials Co. | Yan X.,Changchun SinoBiomaterials Co. | And 3 more authors.
Gaofenzi Cailiao Kexue Yu Gongcheng/Polymeric Materials Science and Engineering | Year: 2012

Wide angle X-ray diffraction (WAXD), small angle x-ray scattering (SAXD), differential scanning calorimetry (DSC), field emission scanning electron microscope (ESEM) and universal testing machine were utilized to study the structures and properties of Poly(L-lactic acid) (PLLA) in different draw ratio conditions. The results show that when draw ratio of PLLA increases from 0 to 6, the degree of crystallinity increases from 3% to 30.8%, the crystallite size increases from 0.9 nm to 3.43 nm, and the long period of crystal face (200) also increases from 50.2 nm to 66.1 nm. The two-dimensional SAXD results show that with the increase of draw ratio, the asymmetric scattering arc of PLLA becomes larger, indicating the increase of orientation degree. The stretching of PLLA also results in fiber orientation structure of PLLA, leading to increase of tensile strength and impact strength, while the elongation at break decreases obviously. Source


Song Z.,Jilin University | Shi B.,CAS Changchun Institute of Applied Chemistry | Shi B.,Jilin University | Ding J.,CAS Changchun Institute of Applied Chemistry | And 7 more authors.
Science China Chemistry | Year: 2015

Complications arising from tendon injury include tendon sheath infection and peritendinous adhesion, in which tendon adhesion often leads to serious motor dysfunction. In this work, the electrospun membranes of poly(L-lactide) (PLA) and poly(ε-caprolactone) (PCL) with different degradation kinetics were used to investigate their efficacy for anti-adhesion toward Achilles tendon repair. Compared with the PCL membrane, the PLA sample showed a faster rate of degradation in 42 d, and all the degradation media (i.e., phosphate-buffered saline) maintained at a constant pH of around 7.4. Meanwhile, the superior biocompatibility of both the PLA and PCL membranes were proved by the in vitro cellular adhesion tests and in vivo histopathological assays. Simultaneously, the PLA membrane was more effective than the PCL sample in decreasing adhesion and promoting functional recovery. Furthermore, the experiment result was further confirmed by hematoxylin-eosin and Masson's trichrome staining, and type I collagen immunohistochemical analysis. All results revealed that the model treated with the electrospun PLA membrane was obviously better with regard to both anti-adhesion and tendon repair than that in the PCL membrane group. Considering the results of degradation and adhesion prevention efficacy, the electrospun polyester membranes, especially the PLA one, would be applied with fascinating potential in clinical prevention of postoperative tendon adhesion. © 2015 Science China Press and Springer-Verlag Berlin Heidelberg. Source


Song Z.-M.,Jilin University | Shi B.,CAS Changchun Institute of Applied Chemistry | Shi B.,Jilin University | Ding J.-X.,CAS Changchun Institute of Applied Chemistry | And 7 more authors.
Chinese Journal of Polymer Science (English Edition) | Year: 2015

An electrospun poly(lactide-co-glycolide) (PLGA) membrane was prepared and used to perform the anti-adhesion of Achilles tendon. Throughout the experiments, the membrane showed an appropriate degradation rate, and the pH values of degradation media were maintained at around 7.4. Simultaneously, the excellent biocompatibility of the membrane in vitro and in vivo was confirmed by live/dead and histopathological analyses. Meanwhile, the membrane can reduce tendon adhesion significantly and promote functional recovery effectively. The encouraging results were further demonstrated by hematoxylin and eosin (H&E), and Masson’s trichrome stainings, and type I collagen immunohistochemical analysis. It was concluded that the model treated with the electrospun PLGA membrane was significantly better with respect to the adhesion prevention and tissue repair than that without treatment. Considering the results of degradation and adhesion prevention efficacy, the electrospun PLGA membrane would be a great candidate for the prevention of postoperative tendon adhesion. © 2015, Chinese Chemical Society, Institute of Chemistry, Chinese Academy of Sciences and Springer-Verlag Berlin Heidelberg. Source


Zhang Y.-B.,Jilin University | Zhang Y.-B.,CAS Changchun Institute of Applied Chemistry | Ding J.-X.,CAS Changchun Institute of Applied Chemistry | Ding J.-X.,Changchun SinoBiomaterials Co. | And 8 more authors.
Chinese Journal of Polymer Science (English Edition) | Year: 2014

Poly(lactide-co-glycolide)-poly(ethylene glycol)-poly(lactide-co-glycolide) (PLGA-PEG-PLGA) triblock copolymer was synthesized through the ring-opening polymerization of LA and GA with PEG as macroinitiator and stannous octoate as catalyst. The amphiphilic copolymer self-assembled into micelles in aqueous solutions, and formed hydrogels as the increase of temperature at relatively high concentrations (> 15 wt%). The favorable degradability of the hydrogel was confirmed by in vitro and in vivo degradation experiments. The good cellular and tissular compatibilities of the thermogel were demonstrated. The excellent adhesion and proliferation of bone marrow mesenchymal stem cells endowed PLGA-PEG-PLGA thermogelling hydrogel with fascinating prospect for cartilage tissue engineering. © 2014, Chinese Chemical Society, Institute of Chemistry, Chinese Academy of Sciences and Springer-Verlag Berlin Heidelberg. Source

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