Changchun City Hospital for Infectious Diseases

Changchun, China

Changchun City Hospital for Infectious Diseases

Changchun, China
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Wang X.,Jilin University | Wu W.,Jilin University | Zhang F.,Changchun City Hospital for Infectious Diseases | Wu S.,Jilin University
Molecules and Cells | Year: 2016

Wound healing is a complex physiological process necessitating the coordinated action of various cell types, signals and microRNAs (miRNAs). However, little is known regarding the role of miRNAs in mediating this process. In the present study, we show that let-7c miRNA is decreased in heat-denatured fibroblasts and that inhibiting let-7c expression leads to the increased proliferation and migration of dermal fibroblasts, whereas the overexpression of let-7c exerts an opposite effect. Further investigation has identified heat shock protein 70 as a direct target of let-7c and has demonstrated that the expression of HSP70 in fibroblasts is negatively correlated with let-7c levels. Moreover, down-regulation of let-7c expression is accompanied by up-regulation of Bcl-2 expression and down-regulation of Bax expression, both of which are the downstream genes of HSP70. Notably, the knockdown of HSP70 by HSP70 siRNA apparently abrogates the stimulatory effect of let-7c inhibitor on heat-denatured fibroblasts proliferation and migration. Overall, we have identified let-7c as a key regulator that inhibits fibroblasts proliferation and migration during wound healing. © The Korean Society for Molecular and Cellular Biology. All rights reserved.


Wang H.,Jilin University | Wang X.,Changchun City Hospital for Infectious Diseases | Li S.,Jilin University
International Journal of STD and AIDS | Year: 2012

Lues maligna is a severe and rare manifestation of syphilis, also known as malignant syphilis or ulceronodular syphilis and mostly occurring in patients with HIV infection. In this report, we present a case of lues maligna in an AIDS patient. Our report shows the typical clinical features of lues maligna and the important association between lues maligna and HIV/AIDS. Although the clinical manifestations of lues maligna are complicated and severe, the response to the therapy of penicillin is excellent.


PubMed | Jilin University and Changchun City Hospital for Infectious Diseases
Type: Journal Article | Journal: Molecules and cells | Year: 2016

Wound healing is a complex physiological process necessitating the coordinated action of various cell types, signals and microRNAs (miRNAs). However, little is known regarding the role of miRNAs in mediating this process. In the present study, we show that let-7c miRNA is decreased in heat-denatured fibroblasts and that inhibiting let-7c expression leads to the increased proliferation and migration of dermal fibroblasts, whereas the overexpression of let-7c exerts an opposite effect. Further investigation has identified heat shock protein 70 as a direct target of let-7c and has demonstrated that the expression of HSP70 in fibroblasts is negatively correlated with let-7c levels. Moreover, down-regulation of let-7c expression is accompanied by up-regulation of Bcl-2 expression and down-regulation of Bax expression, both of which are the downstream genes of HSP70. Notably, the knockdown of HSP70 by HSP70 siRNA apparently abrogates the stimulatory effect of let-7c inhibitor on heat-denatured fibroblasts proliferation and migration. Overall, we have identified let-7c as a key regulator that inhibits fibroblasts proliferation and migration during wound healing.


Cui W.-Y.,Changchun City Hospital for Infectious Diseases | Yan S.-M.,Changchun City Hospital for Infectious Diseases | Zhao Y.-H.,Changchun City Hospital for Infectious Diseases | Yang G.-X.,Changchun City Hospital for Infectious Diseases | And 2 more authors.
Chinese Journal of Biologicals | Year: 2011

Objective: To observe the time limit for virus nucleic acid negative conversion in patients with influenza A (H1N1). Methods: The pharynx swabs of 38 patients with influenza A (H1N1), who were hospitalized in Changchun City Hospital for Infectious Diseases during September 16 to September 27, 2009, were collected by the same doctor, and determined for four virus subtypes, i. e. A, A1, seasonal flu and A(H1N1), by RT-PCR, and those negative for subtypes A, A1 and A(H1N1) were judged as virus nucleic acid negative conversion. Results: The minimum and the maximum time limits of virus nucleic acid negative conversion of 38 patients were 1 and 14 d respectively, with a mean of 4.5 d. The negative conversion mainly appeared on days 3, 4 and 5 after hospitalization, and was significantly higher on day 5 than on day 4 (P < 0.05). The mean time for virus nucleic acid negative conversion of patients receiving antiviral therapy within 36 h after onset was 4.1 d, while those within 37-72 h was 5.2 d. However, the subtypes A, A1 and A (H1N1) of three patients failed to converse simultaneously. Conclusion: Most of patients with influenza A (H1N1) were negative for virus nucleic acid and were non-infectious after receiving antiviral therapy for one week. The time for virus nucleic acid negative conversion might be shortened by receiving antiviral therapy as early as possible (within 36 h). The negative conversions of subtypes A, A1 and A (H1N1) were in agreement. When the three indexes were not conversed simultaneously, care shall be taken to determine whether concurrent infection with other subtypes of influenza A virus occurred.

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