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Wang H.,Jilin University | Wang X.,Changchun City Hospital for Infectious Diseases | Li S.,Jilin University
International Journal of STD and AIDS | Year: 2012

Lues maligna is a severe and rare manifestation of syphilis, also known as malignant syphilis or ulceronodular syphilis and mostly occurring in patients with HIV infection. In this report, we present a case of lues maligna in an AIDS patient. Our report shows the typical clinical features of lues maligna and the important association between lues maligna and HIV/AIDS. Although the clinical manifestations of lues maligna are complicated and severe, the response to the therapy of penicillin is excellent. Source


Cui W.-Y.,Changchun City Hospital for Infectious Diseases | Yan S.-M.,Changchun City Hospital for Infectious Diseases | Zhao Y.-H.,Changchun City Hospital for Infectious Diseases | Yang G.-X.,Changchun City Hospital for Infectious Diseases | And 2 more authors.
Chinese Journal of Biologicals | Year: 2011

Objective: To observe the time limit for virus nucleic acid negative conversion in patients with influenza A (H1N1). Methods: The pharynx swabs of 38 patients with influenza A (H1N1), who were hospitalized in Changchun City Hospital for Infectious Diseases during September 16 to September 27, 2009, were collected by the same doctor, and determined for four virus subtypes, i. e. A, A1, seasonal flu and A(H1N1), by RT-PCR, and those negative for subtypes A, A1 and A(H1N1) were judged as virus nucleic acid negative conversion. Results: The minimum and the maximum time limits of virus nucleic acid negative conversion of 38 patients were 1 and 14 d respectively, with a mean of 4.5 d. The negative conversion mainly appeared on days 3, 4 and 5 after hospitalization, and was significantly higher on day 5 than on day 4 (P < 0.05). The mean time for virus nucleic acid negative conversion of patients receiving antiviral therapy within 36 h after onset was 4.1 d, while those within 37-72 h was 5.2 d. However, the subtypes A, A1 and A (H1N1) of three patients failed to converse simultaneously. Conclusion: Most of patients with influenza A (H1N1) were negative for virus nucleic acid and were non-infectious after receiving antiviral therapy for one week. The time for virus nucleic acid negative conversion might be shortened by receiving antiviral therapy as early as possible (within 36 h). The negative conversions of subtypes A, A1 and A (H1N1) were in agreement. When the three indexes were not conversed simultaneously, care shall be taken to determine whether concurrent infection with other subtypes of influenza A virus occurred. Source

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