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Xian, China

Zeng M.,Zangmeister Cancer Center | Han L.-F.,Changan Hospital
Chinese Journal of Cancer

The developments of medicine always follow innovations in science and technology. In the past decade, such innovations have made cancer-related targeted therapies possible. In general, the term "targeted therapy" has been used in reference to cellular and molecular level oriented therapies. However, improvements in the delivery and planning of traditional radiation therapy have also provided cancer patients more options for "targeted" treatment, notably stereotactic radiosurgery (SRS) and stereotactic body radiotherapy (SBRT). In this review, the progress and controversies of SRS and SBRT are discussed to show the role of stereotactic radiation therapy in the ever evolving multidisciplinary care of cancer patients. Source

Zheng Y.,Xian Jiaotong University | Jia J.,Xian Jiaotong University | Li W.,Xian Jiaotong University | Wang J.,Xian Jiaotong University | And 6 more authors.
Oncology Letters

The present study reports a case of extranodal natural killer (NK)/T-cell lymphoma, nasal type, involving the skin. The clinical manifestations, pathological characteristics, treatment and prognosis of the case were analyzed to improve the clinical diagnosis and treatment for this disease. The patient was a 56-year-old male, presenting with dark red nodules and plaques that had been visible on the nose for half a year. Based on the skin lesions and histopathological and immunohistochemical examination results, the patient was diagnosed with extranodal NK/T-cell lymphoma, nasal type. This disease has unique histopathological and immunohistochemical features and a high malignancy. The condition tends to be misdiagnosed and has a poor prognosis, but seldom involves the skin. In the present case, only radiotherapy was performed, with no relapse occurring within 6 months. © 2014 Spandidos Publications 2014. All rights reserved. Source

Cheng Y.,Shaanxi Traditional Chinese Medicine Hospital | Mei J.-T.,Changan Hospital | Jia X.-K.,Changan Hospital
Journal of Biomaterials and Tissue Engineering

In this study we tried to explore the therapeutic potential of triptolide (TPL), a traditional Chinese medicinal compound, in rat models after the induction of traumatic spinal cord injury. Three main groups (n = 15) of rats were used named as SCI (where only spinal cord injury was induced and no treatment was done), sham control (where only laminectomy was performed), and TPL/SCI group (where injured rats were treated with 5 mg/kg/day intraperitoneal triptolide injection. A study of IKK/NF-kappaB pathway was performed by studying the expression of IKB-α and phospho NFkB through western blotting. MPO activity was explored to study the effect of this compound on infiltration of neutrophiles to the injury site. TUNEL assay was performed to study the possible antiapoptotic properties of TPL and the effect on expression of proinflammatory cytokines was also studied. A statistical analysis was performed where p value less than 0.05 was considered significant. A positive inhibition of IKK/NF-kappaB pathway, decreased MPO activity, less number of apoptotic cells and decreased expression of proinflammatory cytokines was observed in group of rats treated with Triptolide compared to untreated group. It concluded that secondary injury attenuates after primary mechanical injury in rat models by the use of triptolide. © 2015 American Scientific Publishers. Source

Wang R.-A.,PLA Fourth Military Medical University | Li Q.-L.,PLA Fourth Military Medical University | Li Z.-S.,PLA Fourth Military Medical University | Zheng P.-J.,Changan Hospital | And 5 more authors.
Journal of Cellular and Molecular Medicine

Cancer has been considered to be the result of accumulated gene mutations, which result in uncontrolled cell proliferations for a long time. Cancers are also regarded to be capable of immune evasion. Furthermore, resistance to apoptosis was recognized as an important trait of cancer in the last score of years. However, there are numerous paradoxical issues in this whole set of theory. For example, there is no known set of genes of which mutations are responsible for human cancers. As for the trait of 'resistance to apoptosis', the fact is that cancer has increased frequency of apoptosis. The more malignant the tumour is, the more apoptosis shows. In this study, we propose a new theory that apoptosis plays a key role in the malignant progression and metastasis of cancer. The growth of tumour is the difference between tumour cell proliferation and attrition plus the hyperplastic growth of stroma. Increased and unpreventable death caused by innate or environmental factors such as ischaemia and inflammation drives the tumour cells to proliferate relentlessly, move to new lands to establish colonies. In short, increased cell death is the origin of malignancy. © 2012 The Authors. Published by Foundation for Cellular and Molecular Medicine/Blackwell Publishing Ltd. Source

Liang W.,Shaanxi Normal University | Nie Y.,Shaanxi Normal University | Wang J.,Changan Hospital | Wu J.,Changan Hospital | And 6 more authors.
Analytical Chemistry

We report the application of three-dimensional positron emission tomography/computed tomography (PET/CT) for the analysis of 13NO 3 - uptake and 13N distribution in growing kohlrabi. The analytical procedures, equipment parameters, and image reconstruction mode for plant imaging were tested and selected. 13N in growing kohlrabi plants was imaged versus time using both PET movies and PET/CT tomograms. The 13NO3 - transport velocity in kohlrabi from root to petiole was estimated to be 1.0 cm/min. The appearance of shell-shaped 13NO3 - transport pathways, corresponding to the kohlrabi corm, suggests the existence of special routes with higher efficiency for 13NO3 - transport, which tends to have the shortest distances to the leaves or buds. Standardized uptake values (SUVs), used as the representative figures for describing 13N distribution, were quantified versus time at some putative sites of interest. For multiple analysis of the same-plant, 13N distribution in kohlrabi under normal conditions, methionine sulfoximine (MSX) stress, and recovery from MSX stress was examined. The 13N distribution variation studies were also done under the above three growth conditions. Our results suggest a significant downregulation of nitrate uptake in kohlrabi in the presence of MSX. © 2010 American Chemical Society. Source

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