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PubMed | Nizam's Institute of Medical Sciences, Chalmeda Anand Rao Institute of Medical science and Tata Memorial Center
Type: Journal Article | Journal: Indian journal of medical and paediatric oncology : official journal of Indian Society of Medical & Paediatric Oncology | Year: 2016

Treatment and outcome of Hodgkin lymphoma (HL) are the true success story of modern medicine. The data from the developing countries on long-term outcome of patients with HL is sparse.Primary objective is to assess the progression-free survival (PFS). Secondary objective are overall survival (OS) and toxicities.This is a retrospective analysis from the case records from a single institution.Institutional Ethical Committee approval was obtained. Between January 1991 and December 2010, 301 patients (age 18 years) underwent treatment at our institution.Kaplan-Meyer curves were used to calculate the PFS and OS.The median age at presentation was 36 years, range from 19 to 75 years. The male to female ratio was 2.9:1. Seventy-five percent of patients had B symptoms. Majority presented in advanced stage (Stage III and IV) disease (64.7%). Mixed cellularity (74.4%) was the most common histology, followed by nodular sclerosis (13.9%). The most common chemotherapy regimen used was ABVD (61%).Median follow-up of the cohort was 18.5 months (range 2-225). PFS and OS rate at 5 years is 66.3% and 79.7% respectively.


Chaitra B.,Jjm Medical College | Narhare P.,Chalmeda Anand Rao Institute of Medical science | Puranik N.,Karnataka Institute of Medical science | Maitri V.,Command Hospital
Biomedical Research | Year: 2012

The aim of the study was to evaluate the effect of aerobic exercise training on pulmonary function tests in healthy young men. We recruited twenty; apparently healthy male medical students aged 17-20 years. The subjects participated in a 16 weeks aerobic exercise plan. Pulmonary function test was recorded before the commencement of training and at the end of training. The data were analyzed by paired 't' test. P< 0.05 was considered significant. After the training there was significant improvement in pulmonary function tests (P < 0.05). In conclusion, the current study has shown that, there is significant positive relationship between aerobics training and pulmonary function in healthy young men.


Chaitra B.,Jjm Medical College | Narahare P.,Chalmeda Anand Rao Institute of Medical science | Puranik N.,Karnataka Institute of Medical science | Maitri V.,Command Hospital
International Journal of Pharma and Bio Sciences | Year: 2011

The aim of the study was to evaluate the effect of aerobic exercise training on pulmonary function tests in young healthy volunteers. We recruited eighty, apparently healthy medical students of either sex, aged 17-20 years. Randomization into experimental and control groups (40 each), was carried out with a table of random numbers. Experimental group participated in a 16 weeks aerobic exercise plan, while control group had no plan of exercise during that period of time. Pulmonary Function Test was recorded before the commencement of training and at the end of 16 weeks in both the groups. The data were analyzed by paired' test. P < 0.05 was considered significant. After 16 weeks of aerobic training there was significant improvement in pulmonary functions in the experimental group (P < 0.05). In conclusion, the current study has shown that, there is significant positive relationship between aerobic training and pulmonary function tests.


Srinivas Moorthy P.N.,Chalmeda Anand Rao Institute of Medical science | Srivalli M.,Princess Esra Hospital | Rau G.V.S.,Drraus Ent Super Speciality Hospital | Prasanth C.,RIMS
Indian Journal of Otolaryngology and Head and Neck Surgery | Year: 2012

Ear and nose foreign bodies are common problems affecting the children but adults are not an exception. A prospective study involving 87 patients is undertaken concentrating on presentation of patients with various types of ear or nasal foreign bodies. In the present study common presenting complaints and uncommon presentation scenarios encountered by us like a nasal foreign body with intra cranial complications, an impacted middle ear foreign body with mastoiditis is discussed. The present article emphasizes the need of considering presence of foreign bodies even in the absence of appropriate clinical signs and symptoms suggestive of a foreign body in ear or nose. © 2011 Association of Otolaryngologists of India.


Amar C.S.,Chalmeda Anand Rao Institute of Medical science | Ashish J.,Sree Gokulam Medical College | Hajare V.,Navodaya Medical College | Sreekantha,Navodaya Medical College | And 2 more authors.
International Journal of Pharma and Bio Sciences | Year: 2013

Background and Objectives: The yeast like fungus candida is the most common fungal pathogen causing disease in the human beings. As the disease is usually chronic and treatment failure cases were commonly noted, so the study was conducted to know the prevalence and antifungal susceptibility pattern of various candida species isolated from clinical samples. Materials and Results: A total of 1702 subjects were selected, among which 60.2%were male and 39.8% were female. The identification of various candida species was done by saline wet mount, 10% KOH mount, Gram stain, germ tube test, culture on SDA, Chromagar, cornmeal agar, sugar fermentation tests and sugar assimilation tests. Antifungal susceptibility test was done by disc diffusion method.103 candida species were isolated from 1702 samples. Conclusion: Candida albicans is the most common species isolated from clinical specimen and the infection is almost same in both the sexes and predisposing factors like diabetes mellitus, prolonged contact it water were noted. They were advised correct treatment for diabetes mellitus, to limit the contact with water and maintenance of good personal hygiene.


Sheikh N.A.,Kamineni Institute of Medical science | Londhe P.S.,Chalmeda Anand Rao Institute of Medical science
Indian Journal of Forensic Medicine and Toxicology | Year: 2012

The Lip prints are unique and distinguishable for every individual like fingerprints. Lip prints has been utilised in court at very few instances, more and more research need to be conducted in this field with regards to use of lip prints in personal identification and criminal investigation, it will certainly help as useful evidence in Identification and a tool to solve crime. The present study was aimed to study lip prints of different individuals in various quadrants of lip. The study group comprised of 50 males and 50 females. The materials used were lipstick, white bond paper and a magnifying lens. Present study shows that lip-prints are unique to an individual and behold the potential to act as a tool to solve crime.


Chinnam P.,Chalmeda Anand Rao Institute of Medical science | Mohsin M.,Chalmeda Anand Rao Institute of Medical science | Shafee L.M.,Chalmeda Anand Rao Institute of Medical science
Toxicology International | Year: 2012

Objectives: The primary objective of the study is to assess the toxic effect of pioglitazone in mice. Pioglitazone belongs to thiazolidinedione group of oral antidiabetic agents. The earlier drug of this group troglitazone has been withdrawn due to its liver toxicity. The other drug rosiglitazone which was used like pioglitazone as insulin sensitizing agent in type 2 diabetes has been banned due to its cardiovascular side effects, recently. So, Pioglitazone was administered in high doses 1/4 LD 50 and 1/2 LD 50 in mice to assess the acute toxic effect which also correlate with accidental over dose. Materials and Methods: Swiss albino mice of either sex weighing between 20 and 35 gm were selected. 18 mice were taken and divided into 3 groups of 6 each. The mice were kept for overnight fasting and on the following day group I (control) was administered 0.5 ml distilled water as single dose, group II (1/4 LD 50 ) 500 mg/kg pioglitazone as single dose and group III (1/2 LD 50 ) 1000 mg/kg pioglitazone as single dose, orally. All the animals had free access to food and water after drug administration. After 24 hours, mice were sacrificed by cervical dislocation. Heart, liver and kidneys were dissected and subjected to histopathological examination. Results: In group I (control), the histopathological examination of heart, liver and kidneys revealed no changes. In group II (1/4 LD 50 ), there was ventricular hypertrophy of heart in 4 out of 6 mice. Mild congestion of liver and kidneys was seen in 4 out of 6 and 2 out of 6 mice, respectively. In group III (1/2 LD 50 ), 2 mice out of 6 have died within 24 hours of pioglitazone administration. The histopathological studies of remaining 4 mice have shown ventricular hypertrophy of heart and congestion of liver and kidneys. Conclusions: Acute administration of large doses of pioglitazone has shown ventricular hypertrophy with congestion of liver and kidneys in mice which can happen with accidental overdose of pioglitazone in patients. It is therefore advisable not to prescribe pioglitazone in diabetic patients having congestive heart failure as well as in patients having chronic hypertension, since chronic hypertension leads to ventricular hypertrophy which might get worsened.


Pantam N.,Chalmeda Anand Rao Institute of Medical science | Pulloori M.,Chalmeda Anand Rao Institute of Medical science | Alugubelly K.,Chalmeda Anand Rao Institute of Medical science
Journal of Association of Physicians of India | Year: 2014

Stroke in young is a major health problem in developing countries along with CAD, according to various Indian studies its prevalence is 25-34%. Thrombophilic disorders constitute aetiology in 60% cases of stroke of undetermined aetiology. A 20 yrs old young female presented with symptoms of left PCA thrombosis (P2 syndrome), on evaluation – Isolated Protein – S deficiency is noticed. In this case Protein-S deficiency seems to be the only risk factor responsible for stroke. © 2014, Journal of the association of physicians of India. All rights reserved.


Shafee M.,Chalmeda Anand Rao Institute of Medical science | Leena M.S.,Chalmeda Anand Rao Institute of Medical science | Pavani C.,Chalmeda Anand Rao Institute of Medical science | Jogdand G.S.,Chalmeda Anand Rao Institute of Medical science
Indian Journal of Public Health Research and Development | Year: 2013

Background: There was a huge epidemic of Dengue Fever (DF) during 2009 in South India. Thousands of cases of dengue reported to various hospitals during this epidemic. This study was undertaken to evaluate various types of presentations of DF in the region. Objective: To study the clinical presentation and outcome of DF in South India. Method: A retrospective record based study was performed on 500 records of DF cases in a tertiary care hospital in a rural setting. The case records were selected by simple random sampling from Oct. to Dec. 2009. Results: Out of 500 cases majority were males 315(63%) and in the age group of 16 - 30 years. Most common form of infection was DF in 333(66.6%), DF with thrombocytopenia 153(30.6%), Dengue Hemorrhagic Fever (DHF) in nine (1.8%) and Dengue Shock Syndrome in eight (1.6%) cases. The serological test was done among 399(64.8%) patients and 324 (81.20%) were sero-positive. Most common bleeding manifestations were malena, haematuria and gingival bleeding. Total 463(92.6%) got cured, two males (0.4%) had fatal out come and others were referred to other centers. Conclusion: The Dengue epidemic was of mild form with common presentations and very few deaths.


PubMed | Chalmeda Anand Rao Institute of Medical science and Prathima Institute of Medical science
Type: Journal Article | Journal: Cureus | Year: 2015

DNA methylation, a process of adding a methyl group to DNA done by a DNA methyltransferase is a heritable (epigenetic) alteration leading to cancer, atherosclerosis, nervous disorders (Imprinting disorders), and cardiovascular diseases. The role of nutrition in DNA methylation is revealed by identification of methyl variable positions (MVP) on DNA. These regions are more susceptible to DNA methylations. Nutritional supplementation of folic acid and methionine in utero and in adults decreased epigenetic modifications due to its role in DNA metabolism (one carbon metabolism).Thus, in utero and adult supplementation of folic acid and methionine may reduce DNA methylation. This review attempts to highlight the process of DNA methylation, its effect on various diseases, and the probable protective role of nutrition.

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