Ramagiri R.K.,National Institute of Technology Warangal |
Thupurani M.K.,Chaitanya Postgraduate College Autonomous |
Vedula R.R.,National Institute of Technology Warangal
Journal of Heterocyclic Chemistry | Year: 2015
A simple and highly efficient one-pot, three-component synthesis of novel substituted imidazole derivatives has been reported by the reaction of 3-(2-bromoacetyl)-2H-chromen-2-one, ammonium thiocyanate, and phenacyl aniline in the presence of acetic acid as a solvent under reflux condition with good yields. The structures of newly synthesized compounds were characterized by their analytical and spectral data. One of these compounds 4a showed good antibacterial activity against Escherichia coli gram-negative strains. © 2014 HeteroCorporation.