Ch Charan Singh University

Meerut, India

Ch Charan Singh University

Meerut, India
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Pandey R.K.,Ch Charan Singh University | Bhardwaj S.K.,Ch Charan Singh University
Chronobiology International | Year: 2011

This study investigated whether changes in illumination modify perception of day and night conditions in a diurnal species, the Indian weaver bird. Birds were initially subjected to a 12-h light:12-h dark regime (12L:12D; L=20 lux, D =0.5 lux). After every 2 wks, the combinations of light illumination in L and D phases were changed as follows: 20:2 lux, 20:5 lux, 20:10 lux, 20:20 lux, 20:100 lux, and 20:200 lux. Finally, birds were released into dim constant light (0.5 lux) for 2 wks to determine the phase and period of the circadian activity rhythm. They were also laparotomized at periodic intervals to examine the effects of the light regimes on the seasonal testicular cycle. All individuals showed a consistently similar response. As evident by the activity pattern under these light regimes, both in total activity during contrasting light phases and during the 2h in the beginning and end of first light phase, birds interpreted the period of higher light intensity as day, and the period of lower intensity as the night. During the period of similar light intensity, i.e., under LL, birds free-ran with a circadian period (∼24h). In bright LL (20 lux), the activity rhythm was less distinct, but periodogram analysis revealed the circadian period for the group as 24.46±0.41h (mean±SE). However, in dim LL at the end of the experiment, all birds exhibited a circadian pattern with average period of 25.52±0.70h. All birds also showed testicular growth and regression during the 16-wks study. It is suggested that weaver birds interpret day and night subjectively based on both the light intensity and contrast between illuminations during two phases over the 24h. © Informa Healthcare USA, Inc.


Gupta P.K.,Ch Charan Singh University | Kulwal P.L.,Mahatma Phule Agricultural University | Jaiswal V.,Ch Charan Singh University
Advances in Genetics | Year: 2014

The research area of association mapping (AM) is currently receiving major attention for genetic studies of quantitative traits in all major crops. However, the level of success and utility of AM achieved for crop improvement is not comparable to that in the area of human health care for diagnosis of complex human diseases. These AM studies in plants, as in humans, became possible due to the availability of DNA-based molecular markers and a variety of sophisticated statistical tools that are evolving on a regular basis. In this chapter, we first briefly review the significance of a variety of populations that are used in AM studies, then briefly describe the molecular markers and high-throughput genotyping strategies, and finally describe the approaches used for AM studies. The major part of the chapter is, however, devoted to analysis of reasons why the results of AM have been underutilized in plant breeding. We also examine the opportunities available and challenges faced while using AM for crop improvement programs. This includes a detailed discussion of the issues that have plagued AM studies, and the solutions that have become available to deal with these issues, so that in future, the results of AM studies may prove increasingly fruitful for crop improvement programs. © 2014 Elsevier Inc.


Kumar A.,Indian Institute of Toxicology Research | Pant M.C.,University of Lucknow | Singh H.S.,Ch Charan Singh University | Khandelwal S.,Indian Institute of Toxicology Research
Tumor Biology | Year: 2012

Squamous cell carcinoma of head and neck (SCCHN) is the sixth most common cancer globally, and in India, it accounts for 30% of all cancer cases. Epidemiological studies have shown a positive association between defective DNA repair capacity and SCCHN. The underlying mechanism of their involvement is not well understood. In the present study, we have analyzed the relationship between SCCHN and the expression of DNA repair genes namely X-ray repair cross-complementing group 1 (XRCC1), xeroderma pigmentosum group D (XPD), and 8-oxoguanine DNA glycosylase (OGG1) in 75 SCCHN cases and equal number of matched healthy controls. Additionally, levels of DNA adduct [8-hydroxyguanine (8-OHdG)] in 45 SCCHN cases and 45 healthy controls were also determined, to ascertain a link between mRNA expression of these three genes and DNA adducts. The relative expression of XRCC1, XPD, and OGG1 in head and neck cancer patients was found to be significantly low as compared to controls. The percent difference of mean relative expression between cases and controls demonstrated maximum lowering in OGG1 (47.3%) > XPD (30.7%) > XRCC1 (25.2%). A negative Spearmen correlation between XRCC1 vs. 8-OHdG in cases was observed. In multivariate logistic regression analysis (adjusting for age, gender, smoking status, and alcohol use), low expression of XRCC1, XPD, and OGG1 was associated with a statistically significant increased risk of SCCHN [crude odds ratios (ORs) (95%CI) OR 2.10; (1.06-4.17), OR 2.76; (1.39-5.49), and 5.24 (2.38-11.52), respectively]. In conclusion, our study demonstrated that reduced expression of XRCC1, XPD, and OGG1 is associated with more than twofold increased risk in SCCHN. © 2011 International Society of Oncology and BioMarkers (ISOBM).


Dutt K.,University of Delhi | Soni R.K.,Ch Charan Singh University
Iranian Polymer Journal (English Edition) | Year: 2013

Polyethylene terephthalate (PET) waste is not biodegradable; thus, it will create environmental hazards if disposed in landfills. Therefore, the only way of addressing the problem of disposal of post-industrial and post-consumer PET wastes is through recycling. The polyester plasticizer for polyacrylonitrile butadiene rubber (NBR) and polyacrylonitrile butadiene-polyvinylchloride rubber blend (NBR-PVC) was obtained by the depolymerization of PET waste with 2-ethyl-1-hexanol. The PET waste was depolymerized until a polymeric plasticizer with the average molecular weight in the range of 450-900 g/mol was obtained. The polymeric plasticizer was characterized for acid and hydroxyl numbers, viscosity, density, FTIR, NMR and TGA/DTA thermogram. The prepared polymeric plasticizer was used in the preparation of nitrile rubber and nitrile-PVC rubber blend rubber sheets, where these sheets were tested for compatibility, tensile strength, elongation-at-break, hardness and ageing properties. Nitrile rubber and nitrile-PVC blend sheets were also prepared using DOP as a plasticizer and a comparative study with the synthesized polymeric plasticizer was made. It was observed that synthesized polymeric plasticizer provides excellent tensile properties and ageing resistance for high-performance applications as compared to that obtained from DOP. The end uses for nitrile rubber and nitrile-PVC rubber blend compounds are quite diverse, but they can be loosely categorized as being either general performances or higher performance applications. Each of these performance categories requires a different set of considerations in terms of compounding with plasticizers. © 2013 Iran Polymer and Petrochemical Institute.


Verma Y.,Ch Charan Singh University | Rana S.V.S.,Ch Charan Singh University
Environmental Toxicology and Pharmacology | Year: 2011

The aim of the study was to determine the influence of ovariectomy on phase II enzymes viz. glutathione-S-transferase (GST), glutathione peroxidase (GPX) and catalase (CAT) in liver and kidney of female rats treated with benzene. The results showed the significant decrease of the GST and GPX activity in benzene treated rats after ovariectomy. However progesterone supplementation stimulated the activity of GST and GPX in liver and kidney of benzene treated non ovariectomized and ovariectomized rats. Progesterone supplementation to benzene treated ovariectomized rats helps to gain in CAT activity. Our results on DNA damage using single cell gel electrophoresis also confirmed our findings on antioxidant enzymes. The results showed that lack of protective progesterone against benzene toxicity is reflected in alterations in antioxidant enzyme activities. However progesterone therapy to benzene treated ovariectomized rats results in activating the antioxidant defence system. Since female workers are engaged in industrial sector, these results are important from occupational health point of view. Benzene exposure affects their reproductive health. Nevertheless, it could be modulated by suitable hormonal therapy. © 2011 Elsevier B.V.


Kumar A.,University of New Brunswick | Kumar A.,Ch Charan Singh University | Thakkar A.J.,University of New Brunswick
Journal of Chemical Physics | Year: 2010

The construction of the dipole oscillator strength distribution (DOSD) from theoretical and experimental photoabsorption cross sections combined with constraints provided by the Kuhn-Reiche-Thomas sum rule and molar refractivity data is a well-established technique that has been successfully applied to more than 50 species. Such DOSDs are insufficiently accurate at large photon energies. A novel iterative procedure is developed that rectifies this deficiency by using the high-energy asymptotic behavior of the dipole oscillator strength density as an additional constraint. Pilot applications are made for the neon, argon, krypton, and xenon atoms. The resulting DOSDs improve the agreement of the predicted S2 and S1 sum rules with ab initio calculations while preserving the accuracy of the remainder of the moments. Our DOSDs exploit new and more accurate experimental data. Improved estimates of dipole properties for these four atoms and of dipole-dipole C 6 and triple-dipole C9 dispersion coefficients for the interactions among them are reported. © 2010 American Institute of Physics.


Kumar A.,Institute of Engineering and Technology | Kumar M.,Toyohashi University of Technology | Singh B.P.,Ch Charan Singh University
Applied Surface Science | Year: 2010

Arsenic doped p-type ZnO thin films were grown on sapphire substrate by magnetron sputtering. As grown films reveal p-type conduction confirmed by Hall-effect and photoluminescence measurements. The p-type film with a hole concentration of 2.16× 1017 cm-3, mobility of 1.30 cm2/V.s and resistivity of 22.29 Ω-m were obtained at substrate temperature of 700 °C. ZnO homojunction synthesized by in-situ deposition of As doped p-ZnO layer on Al doped n-ZnO layer showed p-n diode like characteristics. X-ray pole figure and Transmission Electron Microscope studies confirm epitaxial nature of the films. Photoluminescence results exhibit the peaks associated with donor acceptor pair emission. © 2010 Elsevier B.V.


Kumar A.,Indian Institute of Toxicology Research | Pant M.C.,University of Lucknow | Singh H.S.,Ch Charan Singh University | Khandelwal S.,Indian Institute of Toxicology Research
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis | Year: 2012

Effective DNA repair machinery ensures maintenance of genomic integrity. Environmental insults, ageing and replication errors necessitate the need for proper DNA repair systems. Any alteration in DNA repair efficacy would play a dominant role in progression of squamous cell carcinoma of head and neck (SCCHN).Genotypes of XRCC1 gene-Arg194Trp, Arg280His, Arg399Gln and XPD Lys751Gln, by PCR-RFLP were studied in 278 SCCHN patients and an equal number of matched healthy controls residing in north India.In XRCC1 polymorphisms, Arg194Trp and Arg399Gln variants showed a reduced risk, whereas, XPD Lys751Gln variants exhibited ∼2-fold increase in SCCHN risk. With XRCC1-Arg280His variants, there was no association with SCCHN risk. Arg399Gln of XRCC1 appears to have a protective role in people those consume alcohol, while XPD Lys751Gln variants indicated ∼2-fold increased risk of SCCHN in all the co-variate groups.Comparison of gene-gene interaction among XRCC1 Arg280His and XPD Lys751Gln suggested enhanced risk of SCCHN by ∼2.3-fold in group one and ∼6.1-fold in group two. In dichotomized groups of this combination, the risk was ∼2.4 times. Haplotype analysis revealed the frequency of C-G-G-G and C-A-G-G to be significantly associated with an increased risk of SCCHN. On the contrary, T-G-A-A significantly diminished the risk. CART analysis results showed that the terminal node that contains homozygous mutants of XPD Lys751Gln and XRCC1 Arg194Trp, wild type of XRCC1 Arg399Gln and homozygous mutant of XRCC1 Arg280His, represent the highest risk group.Our results demonstrate high degree of gene-gene interaction involving DNA repair genes of NER and BER pathways, namely XRCC1 and XPD. This study amply demonstrates positive association of XPD Arg751Gln polymorphism with an increased risk of SCCHN. Further, XRCC1 Arg280His variant though dormant individually, may also contribute to the development of cancer in combination with XPD Arg751Gln. © 2011 Elsevier B.V.


Recently, a two-factor authenticated key agreement scheme for session initiation protocol is published by Lu et al. in Multimedia Tools and Applications [doi:10.1007/s11042-015-3166-4]. I have examined this scheme and found some design flaws in it. Due to flaw in registration phase, the scheme is vulnerable to guessing attacks. However, flaws during key agreement phase hinder the functionality of the scheme in such a way that mutual authentication process between the user and the server is not viable. © 2016 Springer Science+Business Media New York


Dutt K.,University of Delhi | Soni R.K.,Ch Charan Singh University
Polymer Science - Series B | Year: 2013

Many research papers have been contributed by several authors for making PET waste recycling economically and ecologically more viable. Recycling of PET waste was started in last two decades. Most of the authors are devoting their time in getting economically viable solution for development of methods based on either mechanical or chemical recycling. Some success has been obtained in development of chemical recycling methods which provides value added products from PET waste. However, different products developed by chemical recycling have not provided economically enough and reliable methods of recycling of PET waste. © 2013 Pleiades Publishing, Ltd.

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