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Draguignan, France

Mieville F.,University of Lausanne | Beaumont S.,Roche Holding AG | Torfeh T.,Roche Holding AG | Gudinchet F.,CH | Verdun F.R.,University of Lausanne
Radiation Protection Dosimetry | Year: 2010

The purpose of this study was to assess the spatial resolution of a computed tomography (CT) scanner with an automatic approach developed for routine quality controls when varying CT parameters. The methods available to assess the modulation transfer functions (MTF) with the automatic approach were Droege's and the bead point source (BPS) methods. These MTFs were compared with presampled ones obtained using Boone's method. The results show that Droege's method is not accurate in the low-frequency range, whereas the BPS method is highly sensitive to image noise. While both methods are well adapted to routine stability controls, it was shown that they are not able to provide absolute measurements. On the other hand, Boone's method, which is robust with respect to aliasing, more resilient to noise and provides absolute measurements, satisfies the commissioning requirements perfectly. Thus, Boone's method combined with a modified Catphan 600 phantom could be a good solution to assess CT spatial resolution in the different CT planes. © The Author 2010. Published by Oxford University Press. Source


Lavoue V.,Eugene Marquis Comprehensive Cancer Center | Lavoue V.,University of Rennes 2 - Upper Brittany | Roger C.M.,Eugene Marquis Comprehensive Cancer Center | Roger C.M.,University of Rennes 2 - Upper Brittany | And 12 more authors.
Breast Cancer Research and Treatment | Year: 2011

Flat epithelial atypia (FEA) is recognized as a precursor of breast cancer and its management (surgical excision or intensive follow-up) remains unclear after diagnosis on core needle biopsy (CNB). The aim of this study was to determine the underestimation rate of pure FEA on CNB and clinical, radiological, and pathological factors of underestimation. 4,062 CNBs from 5 breast cancer centers, performed over a 5-year period, were evaluated. A CNB diagnosis of pure FEA was made in 60 cases (1.5%) (the presence of atypical ductal hyperplasia, lobular neoplasia, radial scars, phyllodes tumor, papillary lesions, ductal carcinoma in situ or invasive carcinoma at CNB were exclusion criteria), and subsequent surgical excision was systematically performed. The histological diagnosis was retrospectively reviewed using standardized criteria and the precise terminology of the World Health Organization by two pathologist physicians. At surgical excision, 6 (10%) ductal carcinoma in situ and 2 (3%) invasive carcinoma were diagnosed. The total underestimation rate was 13%. FEA was associated with atypical ductal hyperplasia in 10 (17%) cases and with lobular neoplasia in 2 (3%) at final pathology. Residual FEA was found in 14 (23%) cases. No clinical, radiological or pathological factors were significantly associated with underestimation. Our data highlight the importance of recognizing and diagnosing FEA in core needle biopsies. Thus, the presence of FEA on CNB, even in isolation, warrants follow-up excision. © 2010 Springer Science+Business Media, LLC. Source


Degardin A.,CHRU | Devos P.,CH | Vermersch P.,CHRU | De Seze J.,CHRU
Acta Neurologica Belgica | Year: 2010

Clinical reports of cerebrovascular system involvement in sarcoidosis are extremely rare though pathological studies frequently describe granulomatous cerebral arterial and venous lesions. We report the case of a 47-year-old man with a history of pulmonary sarcoidosis at age 32 and abducens palsy at age 40, who presented cerebral pseudotumoral histologically proven sarcoidosis. He was admitted for acute left hemiplegia. Brain CT scan and MRI demonstrated a right posterior parietal haematoma associated with a superior sagittal sinus occlusion. He received intravenous corticosteroids and anticoagulant therapy. Six months later, he presented a right motor status epilepticus. MRI revealed new parenchymal haematomas. Cerebral angiography demonstrated cerebral vasculitis. Source


Lioure B.,CHU | Bene M.C.,University of Lorraine | Pigneux A.,Bordeaux University Hospital Center | Huynh A.,Toulouse University Hospital Center | And 20 more authors.
Blood | Year: 2012

The LAM2001 phase 3 trial, involving 832 patients with acute myeloid leukemia (AML; median: 46 years) proposed HLAidentical sibling allograft HSCT for all patients with an identified donor. The trial compared reduced-intensity conditioning (RIC) for patients older than 50 years of age (N ∇ 47) and myeloablative conditioning for younger patients (N ∇ 117). BM HSCT was performed in the younger patients, while the older ones received a consolidation course, followed by peripheral blood allo-HSCT using RIC. The incidence of grade II-IV acute GVHD, was 51.9% (95% confidence interval [CI]: 42.1- 61.8) and 11.3% (1.6-21.2) after myeloablative or RIC, respectively (P < .0001) and that of chronic GVHD 45.8% (95% CI: 34.8-56.7) and 41.7% (24.7-58.6; NS). Cumulative incidence of nonrelapse mortality at 108 months was 15.8% (95% CI: 9.8-23.2) for myeloablative, and 6.5% (0.2- 16.2) for RIC (NS). CI of relapse at 108 months was 21.7% (95% CI: 13.9-28.6) and 28.6% (16.5-43.4; NS). Overall survival at 108 months was 63.4% (95% CI: 54.6-72.2) and 65.8% (52.2-72.2), respectively, after myeloablative or RIC (NS). RIC peripheral blood stem cell allo- HSCT is prospectively feasible for patients between the ages of 51 and 60 years without excess of relapse or nonrelapse mortality, and compares favorably with myeloablative marrow allo- HSCT proposed to younger patients. This study was registered at clinicaltrials. gov as no. NCT01015196. © 2012 by The American Society of Hematology. Source


Jaggi M.,CH | Rollin S.,Spiez Laboratory | Corcho Alvarado J.A.,University of Lausanne | Eikenberg J.,CH
Applied Radiation and Isotopes | Year: 2012

241Pu was determined in slurry samples from a nuclear reactor decommissioning project at the Paul Scherrer Institute (Switzerland). To validate the results, the 241Pu activities of five samples were determined by LSC (TriCarb and Quantulus) and ICP-MS, with each instrument at a different laboratory. In lack of certified reference materials for 241Pu, the methods were further validated using the 241Pu information values of two reference sediments (IAEA-300 and IAEA-384). Excellent agreement with the results was found between LSC and ICP-MS in the nuclear waste slurries and the reference sediments. © 2011 Elsevier Ltd. Source

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