Alazet S.,University Claude Bernard Lyon 1 |
Zimmer L.,CERMEP in Vivo Imaging Groupement Hospitalier Est |
Zimmer L.,French National Center for Scientific Research |
Billard T.,University Claude Bernard Lyon 1
Chemistry - A European Journal | Year: 2014
A general method for the α-trifluoromethylthiolation of carbonyl compounds, without prefunctionalization, has been developed. Aldehydes, ketones, esters, amides, keto-esters, alkaloids, and steroids have been trifluoromethylthiolated with good yields. This work, proposing a new reagent for electrophilic trifluoromethylthiolation, provides a route towards the original synthesis of various trifluoromethylthiolated molecules for further applications. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.