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Rochester, NY, United States

Grulke E.,University of Kentucky | Reed K.,Cerion Enterprises LLC | Beck M.,University of Kentucky | Huang X.,University of Kentucky | And 2 more authors.
Environmental Science: Nano | Year: 2014

Nanoceria redox properties are affected by particle size, particle shape, surface chemistry, and other factors, such as additives that coat the surface, local pH, and ligands that can participate in redox reactions. Each CeO2 crystal facet has a different chemistry, surface energy, and surface reactivity. Unlike nanoceria's industrial catalytic applications, biological and environment exposures are characterized by high water activity values and relatively high oxygen activity values. Electrochemical data show that oxygen levels, pH, and redox species affect its phase equilibria for solution and dissolution. However, not much is known about how the many and varied redox ligands in environmental and biological systems might affect nanoceria's redox behaviour, the effects of coated surfaces on redox rates and mechanisms, and whether the ceria solid phase undergoes dissolution at physiologically relevant pH and oxygen levels. Research that could answer these questions would improve our understanding of the links between nanoceria's redox performance and its morphology and environmental conditions in the local milieu. © 2014 the Partner Organisations. Source


Cormack A.N.,Alfred University | Lamphier S.,Alfred University | Wang B.,Alfred University | Gubb T.,Alfred University | Reed K.,Cerion Enterprises LLC
Proceedings of the Royal Society A: Mathematical, Physical and Engineering Sciences | Year: 2015

Atomistic computer simulations, using classical potential models, have been used to model ceria nanoparticles (NPs) with diameters of approximately 1 and 2 nm. Lattice expansion is observed in the stoichiometric 1nm NP, consistent with experiment, indicating that reduction is not the primary driver for such expansion. Furthermore, on reduction, the 1 nm NP is found to distort significantly, offering a possible explanation for its reduced oxygen storage capacity compared to the 2 nm NP. Point defect calculations on the 2 nm NP indicate that while doping with La is energetically favourable, Fe incorporation is not. © 2015 The Author(s) Published by the Royal Society. All rights reserved. Source


Patent
Cerion Enterprises LLC | Date: 2013-03-15

A process for making nanoparticles of biocompatible materials is described, wherein an aqueous reaction mixture comprising cerous ion, citric acid and ethylenediaminetetraacetic acid in a predetermined ratio, an oxidant, and water is provided along with temperature conditions to directly form, without isolation, a stable dispersion of cerium oxide nanoparticles. These biocompatible cerium oxide nanoparticles may be used to prevent and/or treat oxidative stress related diseases, such as stroke, relapse/remitting multiple sclerosis, chronic-progressive multiple sclerosis, amyotrophic lateral sclerosis, and ischemic reperfusion injury.


Patent
Cerion Enterprises LLC | Date: 2013-03-19

A process for the production of Li


Patent
Cerion Enterprises LLC | Date: 2013-04-17

A process for making nanoparticles of biocompatible materials is described, wherein an aqueous reaction mixture comprising cerous ion, an -amino acid, an oxidant and water is provided along with temperature conditions to effectively form nanoparticles. These biocompatible nanoparticles may be further conjugated to biologically active agents, such as plasmid DNA, siRNA or proteins, such that a cell transfection agent is formed.

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