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Vinci, Italy

Blosi M.,CNR Institute of Science and Technology for Ceramics | Albonetti S.,University of Bologna | Gatti F.,University of Bologna | Dondi M.,CNR Institute of Science and Technology for Ceramics | And 4 more authors.
Nanotechnology 2010: Advanced Materials, CNTs, Particles, Films and Composites - Technical Proceedings of the 2010 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2010 | Year: 2010

A simple, microwave-assisted route for producing Au/Ag concentred sols by glucose reduction in water was developed. Ag-Au bimetallic nanoparticles stabilized by polyvinylpyrrolidone (PVP) were characterized and their catalytic activity was studied in the reduction of 4-nitrophenol (4-NP) with NaBH 4. Moreover they were tested as red ceramic inks for ink-jet printing technology. Since the research was developed in collaboration with a company interested in the large scale production of the suspensions, some fundamental properties for an industrial scale up were developed: high metal concentration, long time stability. The Au-Ag core-shell structures were prepared by a two-step process. Particle size-control and colloidal stability were achieved thanks to the accurate reaction optimization, combined with microwave heating, that allows the intensification of process even on large scale production. Prepared Au, Ag and Au/Ag nanocrystals acted as effective catalyst for the reduction of 4-NP.

Arosio P.,University of Milan | Arosio P.,Consortium for Science and Technology of Materials | Baldi G.,CERICOL | Chiellini F.,University of Pisa | And 20 more authors.
Dalton Transactions | Year: 2013

Encapsulated Fe3O4 nanoparticles of average diameters d = 12 nm are obtained by coprecipitation, in the presence of 2-methoxyethanol hemiester of poly(maleic anhydride-alt-butyl vinyl ether) 5% grafted with poly(ethylene glycol) (VP-MAG nanoparticles). A complete characterization of nude and encapsulated nanoparticles through structural techniques (namely XRD, TEM, SEM), Raman spectroscopy and magnetic measurements has been performed. These nanoparticles compared with commercial compounds (ENDOREM®) present superparamagnetic behavior and nuclear relaxivities that make them promising as magnetic resonance imaging (MRI) contrast agents (CAs). We found that our nanostructures exhibit r2 relaxivity higher than those of commercial CAs over the whole frequency range. The MRI efficiency of our samples was related to their microstructural and magnetic properties. © 2013 The Royal Society of Chemistry.

Psimadas D.,Technological Educational Institute of Athens | Psimadas D.,Institute of Nuclear and Radiological Science and Technology | Baldi G.,CERICOL | Ravagli C.,CERICOL | And 5 more authors.
Nanotechnology | Year: 2014

Metal oxide nanoparticles, hybridized with various polymeric chemicals, represent a novel and breakthrough application in drug delivery, hyperthermia treatment and imaging techniques. Radiolabeling of these nanoformulations can result in new and attractive dual-imaging agents as well as provide accurate in vivo information on their biodistribution profile. In this paper a comparison study has been made between two of the most promising hybrid core-shell nanosystems, bearing either magnetite (Fe3O4) or cobalt ferrite (CoFe2O4) cores, regarding their magnetic, radiolabeling, hyperthermic and biodistribution properties. While hyperthermic properties were found to be affected by the metal-core type, the radiolabeling ability and the in vivo fate of the nanoformulations seem to depend critically on the size and the shell composition. © 2014 IOP Publishing Ltd.

Psimadas D.,University Hospital of Larissa | Psimadas D.,Institute of Radioisotopes Radiodiagnostic Products | Psimadas D.,Technological Educational Institute of Athens | Baldi G.,CERICOL | And 6 more authors.
Journal of Biomedical Nanotechnology | Year: 2012

Magnetic nanoparticles have become important tools for imaging a wide range of diseases, improving drug delivery and applying hyperthermic treatment. Iron oxide based nanoparticles have been widely examined, unlike cobalt ferrite based ones. Herein, monodisperse and stable CoFe 2O 4nanoparticles have been produced, coated and further stabilized using ethyl 12-(hydroxyamino)-12-oxododecanoate, poly(lactic-co-glycolic acid) and bovine serum albumin. The final product, NBRh1, was fully characterized and has been directly radiolabeled with 99mTc using SnCl 2 as the reducing agent in high yields. In vitro stability and hyperthermic properties of 99mTc-NBRh1 were encouraging for further application in low frequencies hyperthermia and biomagnetic applications. In vivo evaluation followed after injection in healthy mice. The planar and SPECT imaging data as well as the biodistribution results were in accordance, showing high liver and spleen uptake as expected starting almost immediately after administration. In conclusion the preliminary results for nanoparticles bearing a cobalt ferrite core justify further investigations towards potential hyperthermic applications, drug transportation and liver or spleen imaging. Copyright © 2012 American Scientific Publishers All rights reserved.

Baldi G.,CERICOL | Ravagli C.,CERICOL | Mazzantini F.,CERICOL | Loudos G.,Technological Educational Institute of Athens | And 10 more authors.
International Journal of Nanomedicine | Year: 2014

Polymeric nanoparticles with targeting moieties containing magnetic nanoparticles as theranostic agents have considerable potential for the treatment of cancer. Here we report the chemical synthesis and characterization of a poly(D,L-lactide-co-glycolide)-b-poly(ethylene glycol)-based nanocarrier containing iron oxide nanoparticles and human epithelial growth factor receptor on the outer shell. The nanocarrier was also radiolabeled with 99mTc and tested as a theranostic nanomedicine, ie, it was investigated for both its diagnostic ability in vivo and its therapeutic hyperthermic effects in a standard A431 human tumor cell line. Following radiolabeling with 99mTc, the biodistribution and therapeutic hyperthermic effects of the nanosystem were studied noninvasively in vivo in tumor-bearing mice. A substantial decrease in tumor size correlated with an increase in both nanoparticle concentration and local temperature was achieved, confirming the possibility of using this multifunctional nanosystem as a therapeutic tool for epidermoid carcinoma. © 2014 Baldi et al.

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