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Lahore, Pakistan

Fatima I.,CENUM | Munawar M.A.,University of Punjab | Nasir W.,University of Punjab | Khan M.A.,University of Punjab | And 3 more authors.
Journal of the Mexican Chemical Society | Year: 2012

Some novel derivatives of 2-(9H-Purin-6-ylsulfanyl)acetohydrazide were synthesized by reacting it with respective aldehydes in ethanol. The antithyroid effect of these compounds was ascertained in vitro by studying their complexation with iodine spectrophotometrically. In vivo, the hormonal as well as histological variations in male Wistar rats demonstrated significant antithyroid potential (p ≤ 0.05) of these compounds. © 2012, Sociedad Química de México.

Fatima I.,University of Punjab | Munawar M.A.,University of Punjab | Tasneem A.,CENUM | Asmatullah,University of Punjab | Khan M.A.,University of Punjab
Medicinal Chemistry Research | Year: 2012

2,8-Disulfanyl-1,9-dihydro-6H-purin-6-one has been examined in vitro and in vivo, for its potential antithyroid effects. It exhibited stable higher order complexation with iodine in vitro, which is a sign of its possible antithyroid activity. The blood assays of rats were carried out using radioimmunoassay technique to determine free triiodothyronine and thyroxin levels and with ELISA method for thyroid stimulating hormone concentration; which showed a decrease in the former two hormone levels and increase in the latter, for the animals treated with 2,8-disulfanyl-1,9-dihydro-6H-purin-6-one as compared to the control groups. Similarly, thyroid histology of the treated animals depicted hyperactive gland conditions with little colloid material and cylindrical shape of follicular epithelium as compared to the normal cuboidal epithelium with sufficient stores of colloid material in the control animals, which confirms the antithyroid activity of the 2,8-disulfanyl-1,9-dihydro-6H-purin-6-one. The results were also compared with the animals treated with methimazole (1-methyl-1H-imidazole-2-thiol), the well known antithyroid drug and it was found that 2,8-disulfanyl-1,9-dihydro-6H-purin-6-one is more potent than methimazole as far as hormonal variations are concerned. © Springer Science+Business Media, LLC 2011.

Akhtar M.S.,BINO Hospital | Kousar F.,CENUM | Fatmi S.S.,BINO Hospital | Jabeen K.,BINO Hospital | Akhtar K.,BINO Hospital
Journal of the College of Physicians and Surgeons Pakistan | Year: 2012

Objective: To compare the quality of life and symptomatic improvement after palliative radiotherapy to brain metastasis using two different treatment protocols. Study Design: Comparative study. Place and Duration of Study: Bahawalpur Institute of Nuclear Medicine and Oncology, Bahawalpur, from January 2009 to November 2010. Methodology: Patients presenting with brain metastasis referred to Bahawalpur Institute of Nuclear Medicine and Oncology, Bahawalpur for whole brain radiotherapy (WBRT) were included. Patients were divided in two groups. In group A WBRT 30 Gys in 10 fractions were given. While in group B 30 Gys in 15 fractions to whole brain followed by 20 Gys in 10 fractions boost to primary metastatic site with 2 cm margins were given. Follow-up was done at 1 and 3 months. Results: A total of 46 patients with brain metastasis were enrolled with median Karnofsky performance score 50. Median age was 64 years. Most common presenting symptoms were headache, weakness, balance problem and early fatigability. Fifty percent of patients had improvement in their presenting symptoms after completion of palliative radiotherapy at one month and three months follow-up. There was a statistically significant improvement in headache, nausea or vomiting, focal weakness, dizziness, balance problem and problems with smell, hearing and tingling sensation in group B patients as compared to group A. Conclusion: More controlled and better quality of life was observed in patient given 30 Gys in 15 fractions followed by a boost of 20 fractions to primary metastatic site versus WBRT with 30 Gys in 10 fractions and in patients with metastatic sites are less than three and having difference not more than 2 cm apart between two metastatic sites.

Fatima I.,University of Punjab | Munawar M.A.,University of Punjab | Tasneem A.,CENUM
Journal of the Mexican Chemical Society | Year: 2010

Some novel as well as known derivatives of 8-sulfanyl-3,9- dihydro-1H-purine-2,6-dione were synthesized and their antithyroid activity was measured in rats after administration of a daily dose of 20mg/kg via i.p. injection for 15 days. Free thyroxine and triiodothyronine concentrations were determined using radioimmunoassay technique. The assay results showed decrease in the hormonal concentrations for the animals treated with these compounds as compared to the control animals. Similarly, thyroid stimulating hormone level was measured with ELISA method and the results demonstrated a comparative increase of this hormone for the treated animals. The hormonal variations indicated significant (α≤0.05) activity of the compounds. Histological study of thyroid tissues from the test animals showed cellular modifications in the treated animals like cylindrical shape of follicular epithelium, depletion of colloid and high values of thyroid body indices. All these factors further confirmed the antithyroid effects of the compounds under study. © 2010, Sociedad Química de México.

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