Fahy G.M.,Century Inc.
Cryobiology | Year: 2010
Cryoprotectant toxicity is a fundamental limiting factor for the successful cryopreservation of living systems by both freezing and vitrification, and the ability to negate it would be attractive. Past attempts to demonstrate " cryoprotectant toxicity neutralization" (CTN) have had many ups and downs. First convincingly introduced by Baxter and Lathe in 1971, the concept that certain amides can block toxic effects of dimethyl sulfoxide (Me2SO) was contradicted by direct experiments in 1990. But in 1995, the opposite mode of CTN, in which Me2SO blocked the damaging effects of formamide, was robustly demonstrated. Recent experiments have verified the original 1995 results and extended them to urea and acetamide, but no CTN was detected for N-methylamides (N-methylformamide, N,N-dimethylformamide, and N-methylacetamide). On the theory that the latter amides and acetamide might serve as low-toxicity structural analogs of formamide, urea, or Me2SO, competition experiments were carried out between them and formamide or urea, but CTN was not observed for these amide-amide systems. The idea that the N-methylamides might have non-specific rather than specific toxicity was supported by the fact that the concentrations of these amides that cause toxicity are similar to the concentrations that denature model proteins. Clear examples of neutralization of the toxicity of glycerol, propylene glycol, ethylene glycol, or Me2SO are presently lacking, but effects of the latter that depend on sulfhydryl oxidation have been reversed with reducing agents. In summary, CTN is a useful phenomenon with significant theoretical and practical implications. © 2009 Elsevier Inc..
Agency: Department of Defense | Branch: Army | Program: SBIR | Phase: Phase II | Award Amount: 665.36K | Year: 2015
Century has designed and manufactured aluminum metal matrix composite (MMC) brake drums for multiple applications both military and commerical with great success. Applications include axle loads ranging from 8,000 to 23,000 lbs. As applications vary the torque requirements of the brake system also vary. To work with multiple brake systems, multiple friction materials may be required to couple the MMC brake drums. This "family"of friction materials needs to emcompass both low and hig coefficients of friction. Currently available friction materials work very well in low to medium coefficient of friction (Mu) applications such as commercial trucks/braking systems. The purpose of the Phase II effort is to further evaluate the potential for a "newly developed" friction material that will be adaptable to wide-ranging heavy vehicles both in the Military and Commerical markets when coupled with MMC brake drums.
Agency: Department of Health and Human Services | Branch: National Institutes of Health | Program: SBIR | Phase: Phase I | Award Amount: 308.53K | Year: 2015
DESCRIPTION provided by applicant Methicillin resistant staphylococcus aureus MRSA is a serious pathogen that can cause patient mortality and extend hospital stays resulting in higher health care costs Currently over of staph cases around the world are caused by MRSA In recent years MRSA has evolved into several resistant strains that can resist to multiple antibiotics such as penicillin vancomycin tetracycline and erythromycin For this reason they are sometimes called andquot superbugs andquot In recent years these andquot superbugsandquot have become a serious threat to public health Because of the increasing presence of MRSA related infections especially in hospitals there are urgent needs for effective and novel antibiotic therapies In a preliminary study we have isolated a novel compound kaempferol O alpha L andquot andquot di p coumaroyl rhamnoside KCR from the American sycamore Platanus occidentalis that were active against MRSA and VRSA vancomycin resistant staphylococcus aureus in vitro and in vivo The sycamore materials have been classified by the USDA as generally regarded as safe GRAS because of extensive human contact and use of this plant in traditional folk medicines and paper industry among others Active metabolites of these anti MRSA compounds likely possess a distinct mechanism of action as they do not show cross resistance or structural homology with established antibiotics In this proposal we plan to furthe investigate these highly selective anti MRSA KCR platanosides including the maximum tolerated dose MTD therapeutic efficacy pharmacokinetics PK mechanism of action and in vivo toxicity using animal model and microbiological techniques This project clearly has the potential to generate a first in class new antibiotic with a novel mechanism of action and provides a unique opportunity for US economic development In addition the success of this project will address the limitations of current therapies for the control of MRSA and other antibiotic resistant staph infections such as VRSA PUBLIC HEALTH RELEVANCE MRSA stands for methicillin resistant staphylococcus aureus which is a serious drug resistant pathogen that causes patient mortality extend hospital stays and higher health care costs Statistical data suggest that as many as people per year have died from MRSA in the U S In recent years MRSA has evolved into several resistant strains that can resist to multiple antibiotics such as penicillin vancomycin tetracycline and erythromycin For this reason they are sometimes called andquot superbugs andquot In recent years these andquot superbugsandquot have become a serious threat to public health Because of the increasing presence of MRSA related infections there are urgent needs for effective and novel antibiotic therapies In this project we plan to investigate novel leaf compound known as KCR from American sycamore that exhibit potent anti MRSA activity in a preliminary study We propose to further study the therapeutic effects and the biological properties of the extracts using animal model and modern microbiological techniques The success of this project will generate a first in class new antibiotic for treating drug resistant infections This project also will provide a unique opportunity for US economic development
Century Inc. | Date: 2015-08-27
A load bearing panel member having a first portion, a second portion, and an appearance surface portion is formed by injection molding such that the first portion includes a plurality of ribs forming a grid pattern on the first portion and another plurality of ribs extending toward the periphery of the first portion which may be non-orthogonal to each other and to the ribs forming the grid pattern. An internal channel may be formed within each of the non-orthogonal ribs by injecting a gas into the rib during the molding process forming the panel. An appearance surface portion attached to the first portion and second portion of the panel member forms an integral hinge between the first and second portions of the panel member. The panel member may be configured as a floor panel of a vehicle.
Century Inc. | Date: 2015-10-13
Electric aircraft, including in-flight rechargeable electric aircraft, and methods of operating electric aircraft, including methods for recharging electric aircraft in-flight, and method of deploying and retrieving secondary aircrafts.