Roosens B.,Centrum Voor Hart en Vaatziekten |
Roosens B.,Vrije Universiteit Brussel |
Bala G.,Centrum Voor Hart en Vaatziekten |
Bala G.,Vrije Universiteit Brussel |
And 13 more authors.
Ultrasound in Medicine and Biology | Year: 2013
Chronic kidney disease (CKD) and secondary hyper-parathyroidism are associated with calcific aortic valve disease (CAVD). Innovative modalities for imaging CAVD are warranted. Our aim was to use echocardiographic calibrated integrated backscatter (cIB) to quantitatively determine the preventive effect of the calcimimetic R-568 on CAVD in a CKD rat model, and to compare the results with those of micro-computed tomography and histology. Thirty-six male Wistar rats were followed for 7wk. Rats were divided into four groups with respect to treatment: (1) adenine 0.5% to induce CKD+vehicle; (2) adenine+R-568 (30mg/kg/d); (3) control, normal diet+vehicle; (4) controls, normal diet+R-568. At week 7, cIB values of the aortic valve were significantly lower in R-568-treated group 2 than in vehicle-treated group 1. This was confirmed by the significantly lower calcified volume observed on micro-computed tomography and the calcified area observed on histology. There were no significant differences in fractional area change and aortic valve area between groups. In conclusion, echocardiographic cIB was able to quantitatively assess a reduction in CAVD by R-568 in a rat model of CKD. © 2013 World Federation for Ultrasound in Medicine & Biology.