Angra dos Reis, Brazil
Angra dos Reis, Brazil

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Onodera A.N.,University of Sao Paulo | Onodera A.N.,Sul Inc | Neto W.P.G.,Centro Universitario Ritter dos Reis | Roveri M.I.,University of Sao Paulo | And 2 more authors.
PeerJ | Year: 2017

Background. Resilience of midsole material and the upper structure of the shoe are conceptual characteristics that can interfere in running biomechanics patterns. Artificial intelligence techniques can capture features from the entire waveform, adding new perspective for biomechanical analysis. This study tested the influence of shoe midsole resilience and upper structure on running kinematics and kinetics of nonprofessional runners by using feature selection, information gain, and artificial neural network analysis. Methods. Twenty-seven experienced male runners (63 ± 44 km/week run) ran in four-shoe design that combined two resilience-cushioning materials (low and high) and two uppers (minimalist and structured). Kinematic data was acquired by six infrared cameras at 300 Hz, and ground reaction forces were acquired by two force plates at 1,200 Hz. We conducted a Machine Learning analysis to identify features from the complete kinematic and kinetic time series and from 42 discrete variables that had better discriminate the four shoes studied. For that analysis, we built an input data matrix of dimensions 1,080 (10 trials × 4 shoes × 27 subjects) × 1,254 (3 joints × 3 planes of movement × 101 data points C 3 vectors forces + 101 data points C 42 discrete calculated kinetic and kinematic features). Results. The applied feature selection by information gain and artificial neural networks successfully differentiated the two resilience materials using 200(16%) biomechanical variables with an accuracy of 84.8% by detecting alterations of running biomechanics, and the two upper structures with an accuracy of 93.9%. Discussion. The discrimination of midsole resilience resulted in lower accuracy levels than did the discrimination of the shoe uppers. In both cases, the ground reaction forces were among the 25 most relevant features. The resilience of the cushioning material caused significant effects on initial heel impact, while the effects of different uppers were distributed along the stance phase of running. Biomechanical changes due to shoe midsole resilience seemed to be subject-dependent, while those due to upper structure seemed to be subject-independent. © 2017 Onodera et al.


Zampieri F.L.,University Federal da Fronteira Sul | Da Costa Braga A.,Federal University of Rio Grande do Sul | De Ugalde C.M.,Grande Rio University | Rigatti D.,Centro Universitario Ritter dos Reis
SSS 2015 - 10th International Space Syntax Symposium | Year: 2015

Understanding generative pedestrian movement causes is a key urban planning issue, especially when it comes to verify public policies efficiency towards open public spaces maintenance or improvement and the correlation of such governance actions in strengthening social dynamics. Pedestrian movement is a complex phenomenon which patterns emerge from the interaction among multidimensional variables ranging from cultural behavioural patterns underlying social relations, spatial configuration accessibility patterns to sidewalk attributes. The most effective problem-solving tools applied in order to improve pedestrian movement focus on modelling sidewalk attributes through the relations held amidst their physical variables. In this paper we introduce a modelling method which processes data interactions through artificial neural networks and genetic algorithms. Hybrid data parallel processing allow the comparison between potential and empirically measured pedestrian movement based on space syntax variables and sidewalks service levels. It provides accurate and reliable descriptions for public open spaces social appropriation patterns and its correlations to changes in urban grid morphology and functional centralities. The model proved its efficiency in processing simultaneously large data samples which consider whole urban areas global spatial structure, what enabled the impact analysis of large scale vehicular through movement on local scale movement and depict changes on pedestrian behaviour. The empirical case from which data were collected, the city of Criciúma / Brazil, summarizes a pervasive phenomenon to several Brazilian cities located on crossroads-the rupture of a consolidated functional centrality by the convergence between roads and main street sectioning the city core and causing the emergence of dynamic barriers related to heavy traffic through movement which imposes discontinuities to the urban grid, changing natural movement potentials, social appropriation and land use patterns. Modelling data samples altogether for the whole configuration failed to provide significant correlations to measured pedestrian movement. Several modelling tests indicated that axial lines which displayed higher Choice variable values, that is, indicated higher fluxes probability through the urban system were coincident with morphological neighbourhood boundaries. Evidences obtained through the separated modelling of zones bounded by axial lines which displayed higher global Choice values led to the corroboration of the following hypothesis: barriers aroused by high regional and global accessibility road lanes might divide city cores and trigger morphological transformations that induce differentiation among the resulting parts which are coherent to the degree of spatial segregation. The outcome of this complex process at local scale is the socially shared acknowledgment of distinct neighbourhood boundaries defined by drastic changes on the spatial logic underlying the production of urban space depicted by pedestrians through morphological properties changes. It grants legibility to eventual spatial segregation imposed by a through movement route linking the city core to its regional surroundings.


Trevisan L.M.,Federal University of Rio Grande do Sul | Nalin T.,Federal University of Rio Grande do Sul | Tonon T.,Federal University of Rio Grande do Sul | Veiga L.M.,Centro Universitario Ritter dos Reis | And 4 more authors.
Ciencia e Saude Coletiva | Year: 2015

Treatment of phenylketonuria (PKU) includes the use of a metabolic formula which should be provided free of charge by the Unifed Health System (SUS). This retrospective, observational study sought to characterize judicial channels to obtain PKU treatment in Rio Grande do Sul (RS), Brazil. Lawsuits fled between 2001– 2010 and having as benefciaries PKU patients requesting treatment for the disease were included. Of 20 lawsuits fled, corresponding to 16.8% of RS patients with PKU, 19 were retrieved for analysis. Of these, only two sought to obtain therapies other than metabolic formula. In all the other 17 cases, prior treatment requests had been granted by the State Department of Health. Defendants included the State (n = 19), the Union (n = 1), and municipalities (n = 4). In 18/19 cases, the courts ruled in favor of the plaintiffs. Violation of the right to health and discontinuation of State-provided treatment were the main reasons for judicial recourse. Unlike other genetic diseases, patients with PKU seek legal remedy to obtain a product already covered by the national pharmaceutical assistance policy, suggesting that management failures are a driving factor for judicialization in Brazil. © 2015, Associacao Brasileira de Pos - Graduacao em Saude Coletiva. All rights reserved.


Zabadal J.,Federal University of Rio Grande do Sul | Garcia R.,State University of Rio Grande do Sul | Ribeiro V.,Centro Universitario Ritter dos Reis | Van Der Laan F.,Federal University of Rio Grande do Sul
Defect and Diffusion Forum | Year: 2012

This work presents a new analytical method for solving nonlinear heat conduction problems in arbitrary domains. The method is based on approximate mappings which transforms nonlinear partial differential equations into linear models which can be solved using standard techniques. In order to verify whether the proposed formulation can be employed to conceive new online control systems, numerical results are reported. © (2012) Trans Tech Publications.


Duarte J.P.,Centro Universitario Univates | Paludo J.,Federal University of Rio Grande do Sul | Lemos J.R.N.,Centro Universitario Ritter dos Reis | Moreira T.R.,Centro Universitario Univates
Scientia Medica | Year: 2014

Aims: To assess the prevalence of nutritional risk in hospitalized subjects and the agreement in nutritional diagnosis between five nutritional screening protocols. Methods: A cross-sectional study included patients of both genders, aged 18, admitted to hospital from January to March 2013 Within the first 48 hours of admission, the following nutritional screening protocols were applied: Mini Nutrition Assessment (MNA); Mini Nutrition Assessment Short Form (MNA-S); Subjective Global Assessment (ASG); Nutritional Risk Screening (NRS 2002); and Malnutrition Universal Screening Tool (MUST). The protocols consist of questions related to weight loss, body mass index, functional capacity, food appetite and gastrointestinal disturbances. Subjects were classified into two levels: well-nourished and malnourished. Results: A sample of 100 patients were evaluated, which showed 49 (49%) individuals at nutritional risk by the MNA protocol; 53 (53%) by MNA-SF; 23 (23%) by MUST; 7 (7%) by NRS; and 4 (4%) by ASG. The female and aged over 60 years prevailed in the sample. Three protocols, MNA-SF, MUST and NRS, showed a higher nutritional risk in patients over 60 years (p≤0.05). It was observed that MNA and MNA-SF protocols obtained better agreement (Kappa coefficient = 0.760, p<0.001). Conclusions: There was good agreement between the protocols MNA and MNA-SF, but not of those with other protocols, which also showed no correlation with each other. The protocol that ranked the highest percentage of patients at nutritional risk was the MNA-SF, and less nutritional risk was detected by ASG.


De Ugalde C.M.,Grande Rio University | Da Costa Braga A.,Federal University of Rio Grande do Sul | Rigatti D.,Centro Universitario Ritter dos Reis | Zampieri F.L.,University Federal da Fronteira Sul
SSS 2015 - 10th International Space Syntax Symposium | Year: 2015

Porto Alegre, Brazil, was one of the cities where the World Soccer Championship took place in 2014. Like in the other ones, authorities listed a number of decisions to be taken in order to better host thousands of tourists that would be in town not only to watch the games but also to enjoy the city and regional attractions. One of the main aspects to be improved was urban mobility. It was intended by authorities that all journeys should be easy for residents and tourists. Solutions towards straighter paths linking hotspots and attractors, like the airport, bus stations, soccer stadium, restaurants and pubs, hotels, parks and historical areas should be searched by urban planners. Thus, the road system conditions should be evaluated regarding to quickness, safeness and comfort for drivers and passengers. A basic aspect on mobility in cities issue is the urban grid accessibility. The purpose of the research was to discuss the situation in Porto Alegre before the sports event and the effects on accessibility and potential movement caused by the modifications and increments on the grid prescribed by planners and authorities for the World Cup. Seven infrastructure projects in different places were selected for the intended evaluation. Potential co-presence among local population and tourists was analyzed from the results of an overlay between the main street grid, emerged on the spatial configuration, and the specific roads and streets that were potentially coursed by visitors and tourists, in the sense that they could have increased social and economic opportunities as well as cultural exchange during the days of the event. Space syntax measures like step depth, global integration, and choice, were applied not only to evaluate the accessibility but also to identify the potential main routes chosen by tourists and citizens to move from one attractor to another. On one hand, results allowed the conclusion that those infrastructures didn't affect significantly the grid accessibility of Porto Alegre as a whole, although the integration core incorporated some important spaces as consequence of the modifications on connections. On the other hand, the potential routes of movement among different places of interest match with choice foreground network, what suggests that there was a considerable chance of co-presence between Porto Alegre citizens and strangers during the World Cup.


Reolon L.A.,Federal University of Rio Grande do Sul | Reolon L.A.,Centro Universitario Ritter Dos Reis | Martello C.L.,Federal University of Rio Grande do Sul | Schrank I.S.,Federal University of Rio Grande do Sul | Ferreira H.B.,Federal University of Rio Grande do Sul
PLoS ONE | Year: 2014

The characterization of the repertoire of proteins exposed on the cell surface by Mycoplasma hyopneumoniae (M. hyopneumoniae), the etiological agent of enzootic pneumonia in pigs, is critical to understand physiological processes associated with bacterial infection capacity, survival and pathogenesis. Previous in silico studies predicted that about a third of the genes in the M. hyopneumoniae genome code for surface proteins, but so far, just a few of them have experimental confirmation of their expression and surface localization. In this work, M. hyopneumoniae surface proteins were labeled in intact cells with biotin, and affinity-captured biotin-labeled proteins were identified by a gel-based liquid chromatographytandem mass spectrometry approach. A total of 20 gel slices were separately analyzed by mass spectrometry, resulting in 165 protein identifications corresponding to 59 different protein species. The identified surface exposed proteins better defined the set of M. hyopneumoniae proteins exposed to the host and added confidence to in silico predictions. Several proteins potentially related to pathogenesis, were identified, including known adhesins and also hypothetical proteins with adhesin-like topologies, consisting of a transmembrane helix and a large tail exposed at the cell surface. The results provided a better picture of the M. hyopneumoniae cell surface that will help in the understanding of processes important for bacterial pathogenesis. Considering the experimental demonstration of surface exposure, adhesion-like topology predictions and absence of orthologs in the closely related, non-pathogenic species Mycoplasma flocculare, several proteins could be proposed as potential targets for the development of drugs, vaccines and/or immunodiagnostic tests for enzootic pneumonia. © 2014 Reolon et al.


Sartori D.J.,Federal University of Rio Grande do Sul | Leivas P.G.C.,Centro Universitario Ritter dos Reis | de Souza M.V.,Federal University of Rio Grande do Sul | Krug B.C.,Federal University of Rio Grande do Sul | And 2 more authors.
Ciencia e Saude Coletiva | Year: 2012

Court-ordered access to high-cost drugs for rare genetic diseases, such as Fabry Disease (alpha-galactosidase-A deficiency), is a growing phenomenon as yet lacking systematic study. An observational, cross-sectional and retrospective study was conducted to characterize the lawsuits related to access to treatment for Fabry Disease by Enzyme Replacement Therapy in the State of Rio Grande do Sul prior to 2007. The study identified 13 lawsuits and 17 plaintiffs, 11 requesting alfa and 6 betagalsidase. The State of RS, the Federal Government, and 5 municipalities figured as defendants, in the form of joinder of parties or otherwise. There were 13 requests for interlocutory relief of which 12 were granted, and 2 sentences were handed down, both favorable. "Risk of death" was alleged by doctors in 4 prescriptions and by lawyers in the 13 lawsuits. The data suggest the lack of discussions combining aspects of medical efficacy and safety, cost-effectiveness, economic impact, and legal and constitutional arguments, which requires a specific policy for rare genetic diseases to standardize access to treatment.


Siqueira Da Silva I.C.,Federal University of Rio Grande do Sul | Siqueira Da Silva I.C.,Centro Universitario Ritter Dos Reis | Dal Sasso Freitas C.M.,Federal University of Rio Grande do Sul
IMAGAPP and IVAPP 2011 - Proceedings of the International Conference on Imaging Theory and Applications and International Conference on Information Visualization Theory and Applications | Year: 2011

Ontologies are used for sharing among people or software agents the common understanding of the information structure in a certain domain. Usually, ontologies are represented as static 2D graphs where the relationships are displayed as edges, which often overlap and cause cognitive overload. Three-dimensional representations can also lead to confusion due to occlusion. Moreover, as the ontology grows, incorporating new concepts (and their relationships) increases the visualization complexity either in 2D or in 3D. In this paper, we present a study about the requirements of visualization and interaction with ontologies. In order to do that, we interviewed with four experts on ontology creation and use. From the results, we propose the design of a 2.5D visualization tool for exploring relationships between ontology concepts.


PubMed | Secretaria Estadual da Saude do Rio Grande do Sul, Hospital Materno Infantil Presidente Vargas, Centro Universitario Ritter dos Reis and Federal University of Rio Grande do Sul
Type: Journal Article | Journal: Ciencia & saude coletiva | Year: 2015

Treatment of phenylketonuria (PKU) includes the use of a metabolic formula which should be provided free of charge by the Unified Health System (SUS). This retrospective, observational study sought to characterize judicial channels to obtain PKU treatment in Rio Grande do Sul (RS), Brazil. Lawsuits filed between 2001- 2010 and having as beneficiaries PKU patients requesting treatment for the disease were included. Of 20 lawsuits filed, corresponding to 16.8% of RS patients with PKU, 19 were retrieved for analysis. Of these, only two sought to obtain therapies other than metabolic formula. In all the other 17 cases, prior treatment requests had been granted by the State Department of Health. Defendants included the State (n = 19), the Union (n = 1), and municipalities (n = 4). In 18/19 cases, the courts ruled in favor of the plaintiffs. Violation of the right to health and discontinuation of State-provided treatment were the main reasons for judicial recourse. Unlike other genetic diseases, patients with PKU seek legal remedy to obtain a product already covered by the national pharmaceutical assistance policy, suggesting that management failures are a driving factor for judicialization in Brazil.

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