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PubMed | Centro Universitario Of Araraquara, State University of the Central West, Federal University of São Carlos and University of Sao Paulo
Type: | Journal: Revista latino-americana de enfermagem | Year: 2016

to prepare a list of sustainability indicators in the health dimension, for urban solid waste management.a descriptive and exploratory study performed jointly with 52 solid waste specialists, using a three-steps Delphi technique, and a scale measuring the degree of importance for agreement among the researchers in this area.the subjects under study were 92,3% PhDs concentrated in the age group from 30 to 40 years old (32,7%) and 51% were men. At the end of the 3rd step of the Delphi process, the average and standard deviation of all the proposed indicators varied from 4,22 (0,79) to 4,72 (0,64), in a scale of scores for each indicator from 1 to 5 (from dispensable to very important). Results showed the level of correspondence among the participants ranging from 82% to 94% related to those indicators.the proposed indicators may be helpful not only for the identification of data that is updated in this area, but also to enlarge the field of debates of the environmental health policies, directed not only for urban solid waste but for the achievement of better health conditions for the Brazilian context.elaborar uma lista de indicadores de sustentabilidade na dimenso da sade para gesto de resduos slidos urbanos.estudo descritivo e exploratrio, realizado com 52 especialistas na rea de resduos slidos, utilizando a tcnica Delphi em trs etapas, com o uso da escala de mensurao do grau de importncia para obteno de consenso entre pesquisadores da rea da investigao.dos sujeitos estudados , 92,3% eram doutores, com maior concentrao na faixa etria entre 30 e 40 anos (32,7%) e 51,0% do sexo masculino. Ao final da 3 etapa de aplicao da tcnica Delphi, a mdia e o desvio-padro de todos os indicadores propostos variaram de 4,22 (0,79) a 4,72 (0,64), em uma escala de pontuao atribuda para cada indicador de 1 a 5 (Respectivamente, de dispensvel a muito importante). Os resultados demonstraram nvel de concordncia entre os sujeitos participantes que variou de 82% a 94% em relao a esses indicadores.os indicadores propostos podem auxiliar, tanto na identificao de dados atualizados no setor, quanto na ampliao das discusses das polticas de sade ambiental, voltadas no apenas para resduos slidos urbanos, mas objetivando tambm o alcance de melhores condies de sade no contexto da atual realidade brasileira.elaborar una lista de indicadores de sostenibilidad en la dimensin salud para la gestin de residuos slidos urbanos.estudio descriptivo y exploratorio realizado con 52 especialistas en el rea de residuos slidos, utilizando la tcnica Delphi en tres etapas, con uso de escala de medida de grado de importancia para obtencin de consenso entre investigadores de esta rea.de los sujetos estudiados , 92,3% tenan doctorado con mayor concentracin en el grupo etario entre 30 y 40 aos (32,7%) y 51% del sexo masculino. Al final de la 3. Etapa de aplicacin de la tcnica Delphi, el promedio y el desvo estndar de todos los indicadores propuestos variaron de 4,22 (0,79) a 4,72 (0,64), en una escala de puntos atribuida a cada indicador de 1 a 5 (Respectivamente de dispensable a muy importante). Los resultados mostraron un nivel de acuerdo entre los sujetos participantes que vari de 82% a 94% en relacin a estos indicadores.los indicadores propuestos pueden ayudar tanto en la identificacin de datos actualizados en este sector, como tambin para ampliar las discusiones de las polticas de salud ambiental, dirigidas no solamente para residuos slidos urbanos pero tambin para alcanzar mejores condiciones de salud en el contexto de la realidad brasilea actual.

PubMed | Centro Universitario Of Araraquara, São Paulo State University and Federal University of São Carlos
Type: | Journal: Mutation research. Genetic toxicology and environmental mutagenesis | Year: 2016

Tuberculosis is a top infectious disease killer worldwide, caused by the bacteria Mycobacterium tuberculosis. Increasing incidences of multiple drug-resistance (MDR) strains are emerging as one of the major public health threats. However, the drugs in use are still incapable of controlling the appalling upsurge of MDR. In recent years a marked number of research groups have devoted their attention toward the development of specific and cost-effective antimicrobial agents against targeted MDR-Tuberculosis. In previous studies, ruthenium(II) complexes (SCAR) have shown a promising activity against MDR-Tuberculosis although few studies have indeed considered ruthenium toxicity. Therefore, within the preclinical requirements, we have sought to determine the cyto-genotoxicity of three SCAR complexes in this present study. The treatment with the SCARs induced a concentration-dependent decrease in cell viability in CHO-K1 and HepG2 cells. Based on the clonogenic survival, SCAR 5 was found to be more cytotoxic while SCAR 6 exhibited selectivity action on tumor cells. Although SCAR 4 and 5 did not indicate any mutagenic activity as evidenced by the Ames and Cytokinesis block micronucleus cytome assays, the complex SCAR 6 was found to engender a frameshift mutation detected by Salmonella typhimurium in the presence of S9. Similarly, we observed a chromosomal damage in HepG2 cells with significant increases of micronuclei and nucleoplasmic bridges. These data indicate that SCAR 4 and 5 complexes did not show genotoxicity in our models while SCAR 6 was considered mutagenic. This study presented a comprehensive genotoxic evaluation of SCAR complexes were shown to be genotoxic in vitro. All in all, further studies are required to fully elucidate how the properties can affect human health.

Tercjak A.,University of the Basque Country | Gutierrez J.,University of the Basque Country | Barud H.S.,São Paulo State University | Barud H.S.,Centro Universitario Of Araraquara | And 2 more authors.
ACS Applied Materials and Interfaces | Year: 2015

Highly transparent biocomposite based on bacterial cellulose (BC) mat modified with poly(ethylene oxide-b-propylene oxide-b-ethylene oxide) block copolymer (EPE) were fabricated in situ during biosynthesis of bacterial cellulose in a static culture from Gluconacetobacter xylinum. The effect of the addition to the culture medium of water-soluble EPE block copolymer on structure, morphology, crystallinity, and final properties of the novel biocomposites was investigated at nano- and macroscale. High compatibility between components was confirmed by ATR-FTIR indicating hydrogen bond formation between the OH group of BC and the PEO block of EPE block copolymer. Structural properties of EPE/BC biocomposites showed a strong effect of EPE block copolymer on the morphology of the BC mats. Thus, the increase of the EPE block copolymer content lead to the generation of spherulites of PEO block, clearly visualized using AFM and MO technique, changing crystallinity of the final EPE/BC biocomposites investigated by XRD. Generally, EPE/BC biocomposites maintain thermal stability and mechanical properties of the BC mat being 1 wt % EPE/BC biocomposite material with the best properties. Biosynthesis of EPE/BC composites open new strategy to the utilization of water-soluble block copolymers in the preparation of BC mat based biocomposites with tunable properties. © 2015 American Chemical Society.

PubMed | Centro Universitario Of Araraquara, São Paulo State University, Apis Flora Ind. Coml. Ltda and University of the Basque Country
Type: | Journal: Carbohydrate polymers | Year: 2016

A strain isolated from Kombucha tea was isolated and used as an alternative bacterium for the biosynthesis of bacterial cellulose (BC). In this study, BC generated by this novel bacterium was compared to Gluconacetobacter xylinus biosynthesized BC. Kinetic studies reveal that Komagataeibacter rhaeticus was a viable bacterium to produce BC according to yield, thickness and water holding capacity data. Physicochemical properties of BC membranes were investigated by UV-vis and Fourier transform infrared spectroscopies (FTIR), thermogravimetrical analysis (TGA) and X-ray diffraction (XRD). Additionally, scanning electron microscopy (SEM) and atomic force microscopy (AFM) were also used for morphological characterization. Mechanical properties at nano and macroscale were studied employing PeakForce quantitative nanomechanical property mapping (QNM) and dynamic mechanical analyzer (DMA), respectively. Results confirmed that BC membrane biosynthesized by Komagataeibacter rhaeticus had similar physicochemical, morphological and mechanical properties than BC membrane produced by Gluconacetobacter xylinus and can be widely used for the same applications.

Franco-Micheloni A.L.,Paulista University | Fernandes G.,Paulista University | Fernandes G.,Centro Universitario Of Araraquara | Goncalves D.A.G.,Paulista University | Camparis C.M.,Paulista University
Journal of Applied Oral Science | Year: 2014

Temporomandibular disorders (TMD) screeners assume significant item overlap with the screening questionnaire proposed by the American Academy of Orofacial Pain (AAOP). Objective: To test the reliability and validity of the Portuguese version of AAOP questions for TMD screening among adolescents. Material and Methods: Diagnoses from Research Diagnostic Criteria for Temporomandibular Disorders (RDC/TMD) Axis I were used as reference standard. Reliability was evaluated by internal consistency (KR-20) and inter-item correlation. Validity was tested by sensitivity, specificity, predictive values, accuracy and receiver operating characteristic (ROC) curves, the relationship between the true-positive rate (sensitivity) and the false-positive rate (specificity). Test-retest reliability of AAOP questions and intra-examiner reproducibility of RDC/TMD Axis I were tested with kappa statistics. Results: The sample consisted of 1307 Brazilian adolescents (56.8% girls; n=742), with mean age of 12.72 years (12.69 F/12.75 M). According to RDC/TMD, 397 [30.4% (32.7% F/27.3% M)] of adolescents presented TMD, of which 330 [25.2% (27.6% F/22.2% M)] were painful TMD. Because of low consistency, items #8 and #10 of the AAOP questionnaire were excluded. Remaining items (of the long questionnaire version) showed good consistency and validity for three positive responses or more. After logistic regression, items #4, #6, #7 and #9 also showed satisfactory consistency and validity for two or more positive responses (short questionnaire version). Both versions demonstrated excellent specificity (about 90%), but higher sensitivity for detecting painful TMD (78.2%). Better reproducibility was obtained for the short version (k=0.840). Conclusions: The Portuguese version of AAOP questions showed both good reliability and validity for the screening of TMD among adolescents, especially painful TMD, according to RDC/TMD.

Arbex M.A.,Hospital Nestor Goulart Reis | Arbex M.A.,Centro Universitario Of Araraquara | de Siqueira H.R.,State University of Rio de Janeiro | D'Ambrosio L.,Instituto Scientifico | And 2 more authors.
Jornal Brasileiro de Pneumologia | Year: 2015

Here, we report the cases of three patients diagnosed with extensively drug-resistant tuberculosis and admitted to a referral hospital in the state of São Paulo, Brazil, showing the clinical and radiological evolution, as well as laboratory test results, over a oneyear period. Treatment was based on the World Health Organization guidelines, with the inclusion of a new proposal for the use of a combination of antituberculosis drugs (imipenem and linezolid). In the cases studied, we show the challenge of creating an acceptable, effective treatment regimen including drugs that are more toxic, are more expensive, and are administered for longer periods. We also show that treatment costs are significantly higher for such patients, which could have an impact on health care systems, even after hospital discharge. We highlight the fact that in extreme cases, such as those reported here, hospitalization at a referral center seems to be the most effective strategy for providing appropriate treatment and increasing the chance of cure. In conclusion, health professionals and governments must make every effort to prevent cases of multidrug-resistant and extensively drug-resistant tuberculosis. © 2015 Sociedade Brasileira de Pneumologia e Tisiologia.

Nogueira E.N.,Federal University of Mato Grosso | Dores E.F.G.C.,Federal University of Mato Grosso | Pinto A.A.,Federal University of Mato Grosso | Amorim R.S.S.,Federal University of Mato Grosso | And 3 more authors.
Journal of the Brazilian Chemical Society | Year: 2012

This study provides data on the presence of the pesticides atrazine, chlorpyrifos, a-endosulfan, β-endosulfan, flutriafol, malathion and metolachlor in water matrices in urban and rural areas of Campo Verde and Lucas do Rio Verde Cities, Mato Grosso State, Brazil. Surface, rain, and groundwater samples were collected in the rainy and dry seasons during 2007 and 2008 in these important grain-producing areas. The findings revealed a higher diversity of compounds and frequency of detection in the rain water than in surface and groundwater samples. Concentrations of atrazine, endosulfan and malathion above those permitted by Brazilian regulations were found in some surface and groundwater samples, and the degradation products DIA (deisopropylatrazine) and endosulfan sulfate, rather than their parental compounds, were found at higher levels in some samples. Our findings show the vulnerability of water systems in these areas and point to the risk of pesticide contamination in important headwater streams. ©2012 Sociedade Brasileira de Química.

PubMed | Centro Universitario Of Araraquara, Claro and University of Santo Amaro
Type: Journal Article | Journal: Brazilian journal of biology = Revista brasleira de biologia | Year: 2016

Captive animals exhibit stereotypic pacing in response to multiple causes, including the inability to escape from human contact. Environmental enrichment techniques can minimize pacing expression. By using an individual-based approach, we addressed whether the amount of time two males and a female jaguar (Panthera onca) devote to pacing varied with the number of visitors and tested the effectiveness of cinnamon and black pepper in reducing pacing. The amount of time that all jaguars engaged in pacing increased significantly with the number of visitors. Despite the difference between the males regarding age and housing conditions, both devoted significantly less time to pacing following the addition of both spices, which indicates their suitability as enrichment techniques. Mean time devoted to pacing among the treatments did not differ for the female. Our findings pointed out to the validity of individual-based approaches, as they can reveal how suitable olfactory stimuli are to minimizing stereotypies irrespective of particular traits.

Lourencetti C.,São Paulo State University | Lourencetti C.,Federal University of São Paulo | de Marchi M.R.R.,São Paulo State University | Ribeiro M.L.,Centro Universitario Of Araraquara
Journal of Environmental Science and Health - Part B Pesticides, Food Contaminants, and Agricultural Wastes | Year: 2012

This study reports the influence of sugar cane vinasse on the persistence, sorption and leaching potential of diuron (3-(3,4-dichlorophenyl)-1,1-dimethylurea), hexazinone (3-cyclohexyl-6-(dimethylamino)-1-methyl-1,3,5-triazine-2,4-dione) and tebuthiuron (1-(5-tert-butyl-1,3,4-thiadiazol-2-yl)-1,3-dimethylurea) in both a clay and sandy soil from a tropical area of Brazil. The experiments were conducted out under controlled laboratory conditions. The addition of sugarcane vinasse to soil influenced the persistence and sorption of the herbicides in both the studied clay and sandy soils, with a considerable decrease in the diuron DT50 values in clay soil. The Ground Water Ubiquity Score (GUS) Index classifies the herbicides as leachers in both soils and treatments, with the exception of diuron, which is classified as a non-leacher in clay soil-vinasse and as a transient herbicide in sandy soil. These results suggest that special attention should be given to areas such as those where the sandy soil was collected in this study, which is a recharge area of the Guarani Aquifer and is likely to experience groundwater contamination due to the high leaching potential of the applied pesticides. © 2012 Copyright Taylor and Francis Group, LLC.

Fiori A.T.M.,University of Campinas | Lustri W.R.,Centro Universitario Of Araraquara | Magalhaes A.,University of Campinas | Corbi P.P.,University of Campinas
Inorganic Chemistry Communications | Year: 2011

A novel gold(I) complex with ibuprofen was synthesized and characterized by chemical and spectroscopic measurements. Elemental analysis led to the composition AuC14H18O2N. Infrared, 1H and 13C NMR data suggest coordination of the ligand to Au(I) through the oxygen atom of the carboxylic group in a monodentate form. An antibiotic sensitive profile indicated antibacterial activity in vitro of the complex against Gram-negative (E. coli and P. aeruginosa) and Gram-positive (S. aureus) microorganisms. © 2010 Elsevier B.V. All rights reserved.

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