Belo Horizonte, Brazil
Belo Horizonte, Brazil

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Resende R.G.,Hospital Municipal Odilon Behrens | Correia-Silva J.D.F.,Centro Universitario Newton Paiva | Silva T.A.,Federal University of Minas Gerais | Salomao U.E.,Federal University of Minas Gerais | And 4 more authors.
Mediators of Inflammation | Year: 2014

Although interleukin-17 (IL-17) is a recently discovered cytokine associated with several autoimmune diseases, its role in the pathogenesis of chronic graft-versus-host disease (cGVHD) was not established yet. The objective of this study was to investigate the association of IL17A and IL17F genes polymorphisms and IL-17A and IL-17F levels with cGVHD. IL-17A expression was also investigated in CD4+ T cells of patients with systemic cGVHD. For Part I of the study, fifty-eight allo-HSCT recipients and donors were prospectively studied. Blood samples were obtained to determine IL17A and IL17F genes polymorphisms. Cytokines levels in blood and saliva were assessed by ELISA at days +35 and +100 after HSCT. In Part II, for the immunophenotypic evaluation, eight patients with systemic cGVHD were selected and the expression of IL-17A was evaluated. We found association between recipient AA genotype with systemic cGVHD. No association was observed between IL-17A levels and cGVHD. Lower IL-17A levels in the blood were associated with AA genotype. In flow cytometry analysis, decreased expression of IL-17A was observed in patients with cGVHD after stimulation. In conclusion, IL-17A may have an important role in the development of systemic cGVHD. © 2014 Renata Gonçalves Resende et al.


Carneiro A.C.L.L.,Centro Universitario Newton Paiva | De Souza V.,Federal University of Minas Gerais | Godinho L.K.,Federal University of Minas Gerais | De Faria I.C.M.,Federal University of Minas Gerais | And 2 more authors.
Revista Panamericana de Salud Publica/Pan American Journal of Public Health | Year: 2012

Objective: To investigate whether the educational initiatives carried out in basic health units in Belo Horizonte, Minas Gerais, Brazil, follows the principles of health promotion. Methods: This descriptive study examined 33 educational health promotion initiatives to determine whether they were guided by five principles, used as categories of analysis: multicausality of the health-disease process, intersectoriality, social engagement, sustainability, and use of dialogic teaching methods (active participation of subjects in the learning process, planning the activity to generate new knowledge, and use of various teaching strategies). Structured observation was used for data collection. The frequency of each category was evaluated in each initiative. Results: Multicausality was the most frequent category observed (73.0%), and intersectoriality the least frequent (9.0%). Regarding the use of dialogic methods, 38.0% of the initiatives promoted the active engagement of subjects, 6.0% promoted knowledge generation, and 40.0% employed a variety of teaching strategies. Conclusions: Most educational initiatives were not actively oriented toward health promotion, understood as the strengthening of autonomy and self-management of health processes, social engagement, and employment of dialogic teaching approaches. However, some progress has been made moving away from hegemonic models of education in primary health care.


Chrcanovic B.R.,Maria Amelia Lins Hospital | Abreu M.H.N.G.,Federal University of Minas Gerais | Freire-Maia B.,Pontifical Catholic University of Minas Gerais | Souza L.N.,Centro Universitario Newton Paiva
Dental Traumatology | Year: 2010

Aim: The purpose of this study was to review the etiology, incidence and treatment of selected oral and maxillofacial fractures in children in Belo Horizonte, Brazil, during a period of 3 years. Materials and methods: The data collected for this study included age, gender, etiology, date of trauma, associated maxillofacial trauma, anatomic site of fracture and treatment. The analysis involved descriptive statistics and chi-squared test, Bonferroni test, Kolmogorov-Smirnov, Kruskal-Wallis and Mann-Whiney tests and analysis of variance. Results and conclusions: This study examined 566 facial fractures in 464 children of 18 years of age or less. The majority of fractures were observed in children within the age group of 13-18 years of age. Bicycle accidents were the major cause of trauma, followed by falls. The mandible was found to be the most common fractured bone in the facial skeleton, followed by the nose. A conservative approach was applied in most cases. © 2010 John Wiley & Sons A/S.


Angonesi D.,Centro Universitario Newton Paiva | Sevalho G.,Federal University of Minas Gerais
Ciencia e Saude Coletiva | Year: 2010

The Pharmaceutical Care concepts were analyzed from their origins in the United States and the later contributions which came from Spain and from the effort of sistematization by the World Health Organization to understand the processs that has been happening in Brasil. After the abandon of the communitarian pharmacy, the Brazilian pharmacists hope that this new model of practicing is the way to get back his/her social role. The philosophy which directs the Pharmaceutical Care, having the focus on patient, in our understanding, must support philosophical and conceptually the rebuilding of pharmaceutical practicing in Brazil in order to get back the lost relation between the pharmacist and patient at communitarian pharmacy.


Chrcanovic B.R.,Maria Amelia Lins Hospital | Souza L.N.,Centro Universitario Newton Paiva | Freire-Maia B.,Pontifical Catholic University of Minas Gerais | Abreu M.H.N.G.,Federal University of Minas Gerais
Journal of Trauma - Injury, Infection and Critical Care | Year: 2010

Background: An increasing incidence of maxillofacial trauma in the elderly has been noted, as a consequence of increased longevity, resulting in a higher percentage of elderly people in the population. Methods: A retrospective study was undertaken to assess facial fractures in elderly presenting during the period 2000 to 2002 in Belo Horizonte, Brazil. The data collected included age, gender, etiology, date of trauma, maxillofacial trauma, anatomic site of fracture, and treatment. The statistical analysis involved evaluation of measures of central tendency and variability and calculation of proportions. Results: It encountered 165 facial fractures in 122 elderly aged 60 years or older. The majority of fractures were sustained by elderly in the age group 60 years to 69 years. Falls was the major cause of trauma followed by car accidents. The mandible was found to be the most common fractured bone in the facial skeleton, followed by the zygomatic complex. A conservative approach was accomplished in the most of cases. Conclusion: Gender was associated with the presence or absence of fractures and with the etiology. There was no association between age and fractures. No association was found between etiology and age for women and men. The proportion of fractures of the zygomatic arch, mandible body, and parasymphysis treated surgically were statistically higher than the same proportion among the cases of other fractures. The fractures of the nose were more often treated conservatively than other fractures. Copyright © 2010 by Lippincott Williams & Wilkins.


Moura R.M.F.,Centro Universitario Newton Paiva | Navarro T.P.,Hospital Municipal Odilon Behrens HOB | Britto R.R.,Federal University of Minas Gerais | Dias R.C.,Federal University of Minas Gerais
Revista Brasileira de Fisioterapia | Year: 2010

Objectives: To evaluate the quality of life (QOL) of patients with chronic venous disease (CVD) and to analyze the relationship between QOL and disease severity. Methods: This was a cross-sectional study with a convenience sample of 50 participants with a diagnosis of CVD. The participants were classified according to disease severity using the CEAP clinical classification (Clinical manifestations, Etiological factors, Anatomical distribution of disease, Pathophysiological findings). They were then divided into two groups: CEAP 1, 2 and 3 (less clinically compromised) and CEAP 4, 5 and 6 (more clinically compromised). QOL was evaluated using the SF-36 questionnaire. The Mann-Whitney U test was used to compare the SF-36 scores between the groups. The Spearman correlation was used to evaluate the association between QOL and the CEAP. Differences were considered statistically significant with p < 0.05. The SPSS statistical software version 16.0 was used for the analyses. Results: Seventy-four percent of the sample was female. The mean age was significantly higher (p<0.001) among participants classified as CEAP 4, 5 and 6 (56.6±10.3) than among those classified as CEAP 1, 2 and 3 (40.6±10.7). All the domains of the physical component of the SF-36 presented significantly lower scores in the CEAP 4, 5 and 6 group (p<0.05), thus showing greater physical and functional impairment. Only the domains of the physical component presented statistically significant negative correlations with the CEAP. Conclusions: The physical and functional characteristics were more impaired, especially in the more severe forms of CVD. These findings may contribute to a better understanding of the effects of CVD on QOL and better management of therapeutic interventions in this population. © Revista Brasileira de Fisioterapia.


Da Silva V.S.,Federal University of Minas Gerais | Teixeira L.I.,Federal University of Minas Gerais | Do Nascimento E.,Federal University of Minas Gerais | Do Nascimento E.,Centro Universitario Newton Paiva | And 2 more authors.
Applied Catalysis A: General | Year: 2014

This work describes the synthesis and characterization of the novel catalyst 5-(3-bromo,4-amino)phenyl-10,15,20-trisphenyl-2,3,7,8,12,13,17,18- octabromoporphyrinmanganese(III) chloride (MnIIIBr 9APTPPCl). This compound, MnIIIAPTPPCl and Mn IIITPPCl were employed as catalysts in cyclohexane oxidation using PhIO or PhI(OAc)2 as oxidants. In the reactions with PhIO and PhI(OAc)2, MnIIIBr9APTPPCl led to higher yields of products compared to the other catalysts. Furthermore, for the first time it was observed a recovery of the third generation (β-octabrominated) catalyst in reactions using PhI(OAc)2 as oxidant. Reactions were performed with the addition of imidazole or water as additives. The reactions with imidazole showed higher yields for cyclohexanol in all systems studied. For systems using PhIO it was also observed a decrease of catalysts oxidative destruction. All the systems using PhIO and water led to an increase in product yield. However, the recovery of catalyst was low for almost all these systems. Nevertheless, this is the first work to show the role of water as an effective additive in the oxidation of cyclohexane catalyzed by manganese porphyrins. © 2013 Elsevier B.V.


The aim of this work was the single-laboratory validation of a quantitative method for the determination of amoxicillin residues in support of cleaning control and validation. Linearity was demonstrated between 2.5 and 17.5 μg/mL, without matrix effects. Mean recoveries ranged from 84.00 to 103.74% and the relative standard deviation under repetitivity and within- reproducibility conditions were from 0.58 to 4.20% and from 0.79 to 4.39%, respectively. The theoretical limits of detection and quantification were 0.133 and 0.442 μg/mL, respectively. The studied method was suitable for cleaning control purpose within good manufacturing practices.


Angonesi D.,Centro Universitario Newton Paiva | Renno M.U.P.,Centro Universitario Newton Paiva
Ciencia e Saude Coletiva | Year: 2011

The dispensation of pharmaceuticals is an activity that cannot be restricted only to the delivery of medication. The pharmacist must ensure various conditions to ensure that the patient uses the medication in the best possible manner. As it is a professional activity and has been established for pharmaceutical care, dispensation should also have a philosophy of practice, a process of care, and a system for managing the practice. This paper proposes a new definition of dispensation and describes its central elements, considering the reality of established pharmacists, so that it can be effectively implemented.


Zocratto O.B.,Federal University of Ouro Preto | Zocratto K.B.F.,Centro Universitario Newton Paiva | Mao A.Y.Y.,Federal University of Ouro Preto | Oliveira G.S.,Instituto Metropolitano Of Ensino Superior | Ferreira L.,Instituto Metropolitano Of Ensino Superior
European Archives of Oto-Rhino-Laryngology | Year: 2012

To evaluate the relationship between the occurrence of tracheocutaneous fistula of the proximal tracheal stump regarding the indication (therapeutic or prophylactic) of laryngotracheal separation surgery (LTS) and regarding the presence of a current or previous tracheostomy when LTS was performed. Retrospective analysis of 66 patients submitted to LTS. The tracheocutaneous fistula occurred in 14 (21.2%) patients. Twelve (33.3%) of 36 patients whose indication was therapeutic and in two (6.7%) of 30 patients whose indication was prophylactic (p = 0.019). It occurred in 8 (57.1%) of 14 patients who had undergone tracheostomy prior to completion of LTS, while occurred in 6 (11.5%) patients who had not previously undergone tracheostomy (n = 52) (p = 0.0009). The incidence of tracheocutaneous fistula as a postoperative complication of laryngotracheal separation is high and occurs mainly in patients whose indication is therapeutic and for those with a current or previous tracheostomy. Despite the significant incidence, most of them closed spontaneously through the adoption of conservative therapy. © Springer-Verlag 2012.

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