Centro Universitario La Salle

Canoas, Brazil

Centro Universitario La Salle

Canoas, Brazil
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Queiroz-Telles F.,Federal University of Paraná | Fahal A.H.,University of Khartoum | Falci D.R.,Hospital Of Clinicas Of Porto Alegre | Falci D.R.,Centro Universitario La Salle | And 4 more authors.
The Lancet Infectious Diseases | Year: 2017

Fungi often infect mammalian hosts via the respiratory route, but traumatic transcutaneous implantation is also an important source of infections. Environmental exposure to spores of pathogenic fungi can result in subclinical and unrecognised syndromes, allergic manifestations, and even overt disease. After traumatic cutaneous inoculation, several fungi can cause neglected mycoses such as sporotrichosis, chromoblastomycosis, mycetoma, entomophthoramycosis, and lacaziosis. Most of these diseases have a subacute to chronic course and they can become recalcitrant to therapy and lead to physical disabilities, including inability to work, physical deformities, and amputations. For many years, paracoccidioidomycosis was considered the most prevalent endemic systemic mycosis in the Americas, but this situation might be changing with recognition of the worldwide presence of Histoplasma capsulatum. Both paracoccidioidomycosis and histoplasmosis can mimic several infectious and non-infectious medical conditions and lead to death if not recognised early and treated. Cutaneous implantation and systemic mycoses are neglected diseases that affect millions of individuals worldwide, especially in low-income countries where their management is suboptimum because challenges in diagnosis and therapeutic options are substantial issues. © 2017 Elsevier Ltd.


Ramos C.G.,Centro Universitario La Salle | Querol X.,CSIC - Institute of Environmental Assessment And Water Research | Dalmora A.C.,Centro Universitario La Salle | de Jesus Pires K.C.,Washington Luiz | And 3 more authors.
Journal of Cleaner Production | Year: 2017

This study was developed to evaluate the chemical and mineralogical properties of acid volcanic rock waste from mining activities by measuring the availability of macronutrients and micronutrients in Milli-Q water, and in acidic solutions to evaluate the potential use of this type of waste as natural soil fertilizers. The sample used in this work was obtained from a company of the mining district of Nova Prata, Rio Grande do Sul State, southern Brazil. Petrographic studies using conventional optical microscopy and scanning electron microscope allowed to define the mineral composition of in powder wastes as being comprised mainly by pyroxene, feldspar, and variable contents of amorphous glass in matrix. The primary oxides detected in the samples by X-ray Fluorescence were calcium oxide, silicon dioxide, aluminium oxide, iron oxide, and with concentration minor potassium oxide, and phosphorus oxide. Several important nutrients were transferred into the acidic solutions, indicating the significant potential and feasibility of these wastes to be effectively used as natural fertilizers. This study is of great relevance to the sector of mining and to agriculture in the region because it can create an alternative disposal treatment for tailings, and improve the environmental sustainability of local farms, thereby avoiding excessive chemical fertilizer consumption. © 2016 Elsevier Ltd


Grant
Agency: European Commission | Branch: FP7 | Program: CSA | Phase: INFRA-2007-1.2.3;INFRA-2007-1.2-03 | Award Amount: 5.11M | Year: 2008

EELA-2 aims to build, on the current EELA e-Infrastructure, a high capacity, production-quality, scalable Grid Facility providing round-the-clock, worldwide access to distributed computing, storage and network resources for a wide spectrum of applications from European and Latin American scientific communities. The project will provide an empowered Grid Facility with versatile services fulfilling application requirements and ensure the long-term sustainability of the e-Infrastructure beyond the term of the project. The specific EELA-2 objectives are: - Build a Grid Facility by: Expanding the current EELA e-Infrastructure to consist of more production sites mobilising more computing nodes and more storage space, at start of the project and to further grow storage over the duration of the project; Providing, in collaboration with related projects (e.g. EGEE), the full set of Grid Services needed by all types of scientific applications; Supporting applications various types (from classical off-line data processing up to control and data acquisition of scientific instruments), selected against well defined criteria (including grid added value, suitability for Grid deployment, outreach/potential impact); - Ensure the Grid Facility sustainability: Through the already established and new contacts with policy/decision makers, collaborating with RedCLARA and NRENs and supporting the ongoing creation of e-Science Initiatives and/or National Grid initiatives (NGI). Building the support of the e-Infrastructure to provide a complete set of Global Services from a Central Operation Centre and to pave the way for the creation of Regional Operation Centres in Latin America: Attracting new applications; Making available knowledge of EELA-2 Grid Facility to all potential users, developers, and decision makers through an extensive Training and Dissemination program; Creating knowledge repositories federated with the EGEE ones.


Ribeiro V.L.S.,Federal University of Rio Grande do Sul | dos Santos J.C.,Federal University of Rio Grande do Sul | Bordignon S.A.L.,Centro Universitario La Salle | Apel M.A.,Federal University of Rio Grande do Sul | And 2 more authors.
Bioresource Technology | Year: 2010

Hesperozygis ringens (Benth.) Epling (Lamiaceae) is a strongly aromatic plant employed popularly for its antiparasitic properties. The leaves afforded 4% of essential oil constituted mainly by pulegone (86%). Laboratory tests were carried out to determine the toxicity of the essential oil species on engorged females and larvae of the cattle tick Riphicephalus (Boophilus) microplus using the adult immersion test (AIT) and the larval immersion test (LIT). It was observed that the essential oil at the concentration of 50 μL/mL and 25 μL/mL inhibited the egg laying significatively in relation to the controls and the eggs from these treated females were affected by the oil; the hatching was inhibited in 95% and 30%, respectively. In the LIT it was verified that the LC99.9, LC50 and LC1 was 0.541 μL/mL, 0.260 μL/mL and 0.015 μL/mL, respectively. Pulegone, isolated from the oil, showed similar effect on the females and on the larvae, indicating that it is responsible for the oil activity. © 2009 Elsevier Ltd. All rights reserved.


Kahl V.F.S.,Lutheran University of Brazil | da Silva J.,Lutheran University of Brazil | da Silva F.R.,Centro Universitario La Salle
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis | Year: 2016

Various pesticides in the form of mixtures must be used to keep tobacco crops pest-free. Recent studies have shown a link between occupational exposure to pesticides in tobacco crops and increased damage to the DNA, mononuclei, nuclear buds and binucleated cells in buccal cells as well as micronuclei in lymphocytes. Furthermore, pesticides used specifically for tobacco crops shorten telomere length (TL) significantly. However, the molecular mechanism of pesticide action on telomere length is not fully understood. Our study evaluated the interaction between a complex mixture of chemical compounds (tobacco cultivation pesticides plus nicotine) and proteins associated with maintaining TL, as well as the biological processes involved in this exposure by System Biology tools to provide insight regarding the influence of pesticide exposure on TL maintenance in tobacco farmers. Our analysis showed that one cluster was associated with TL proteins that act in bioprocesses such as (i) telomere maintenance via telomere lengthening; (ii) senescence; (iii) age-dependent telomere shortening; (iv) DNA repair (v) cellular response to stress and (vi) regulation of proteasome ubiquitin-dependent protein catabolic process. We also describe how pesticides and nicotine regulate telomere length. In addition, pesticides inhibit the ubiquitin proteasome system (UPS) and consequently increase proteins of the shelterin complex, avoiding the access of telomerase in telomere and, nicotine activates UPS mechanisms and promotes the degradation of human telomerase reverse transcriptase (hTERT), decreasing telomerase activity. © 2016 Elsevier B.V.


Garcia K.O.,Federal University of Rio Grande do Sul | Teixeira E.C.,Federal University of Rio Grande do Sul | Agudelo-Castaneda D.M.,Federal University of Rio Grande do Sul | Braga M.,Centro Universitario La Salle | And 4 more authors.
Science of the Total Environment | Year: 2014

The objective of this research was to evaluate nitro-polycyclic aromatic hydrocarbons (NPAHs) associated with ultrafine airborne particles (PM1) in areas affected by vehicles in the metropolitan area of Porto Alegre (MAPA), RS, Brazil. Extraction, isolation/derivatization, and subsequently gas chromatography with electron capture detection (GC/ECD) were the techniques used to extract and determine NPAHs (1-nitronaphthalene, 2-nitrofluorene,3-nitrofluoranthene,1-nitropyrene, and 6-nitrochrysene) associated with PM1 Airborne particles (PM1) were collected using PTFE filters in a PM162M automatic sampler. The analytical method was validated by the Standard Reference Material - SRM 1649b - from the National Institute of Standards and Technology (NIST, USA). The results were consistent with the certified values. 3-NFlt and 6-NChr reached highest concentrations of 0.047ng·m-3 and 0.0284ng·m-3, respectively, in Sapucaia do Sul and Canoas. Seasonal variation showed higher NPAH concentrations in cold days. The NPAHs associated with PM1 were correlated with the pollutants nitrogen oxides and NPAHs with meteorological variables: temperature and wind speed. The results indicated that vehicles with diesel engines were influential. This was confirmed by the study of the ratios NPAHs/PAHs, 1-NPyr/Pyr, and 6-NChr/Chr. © 2014 Elsevier B.V.


Rampon D.S.,Federal University of Rio Grande do Sul | Rodembusch F.S.,Federal University of Rio Grande do Sul | Schneider J.M.F.M.,Federal University of Rio Grande do Sul | Bechtold I.H.,Federal University of Santa Catarina | And 3 more authors.
Journal of Materials Chemistry | Year: 2010

A simple and efficient procedure for the synthesis of a new class of selenoesters 4a and 4b was developed. Polarized-light optical microscopy (POM), differential scanning calorimetry (DSC), and X-ray diffraction showed that the selenoester 4a with a shorter alkyl chain displayed a wide nematic range (ΔT = 110.7 °C), while 4b with a longer alkyl chain possesses a rich phase polymorphism: Cr → SmI → SmC → N → I mesophase sequence during heating cycle and I → N → SmC → SmI → SmX → Cr transition on cooling. For 4b, a large temperature range (135.7 °C) from crystal to isotropic phase can be observed. In addition, UV-Vis, steady-state fluorescence emission and excitation spectra in solution were also applied in order to characterize their photophysical behaviour. Compounds 4a and 4b are fluorescent in the blue region and present a Stokes shift at around 80 nm and 39 nm in dichloromethane and dioxane, respectively. © 2010 The Royal Society of Chemistry.


Ribeiro J.,University of Porto | DaBoit K.,Institute of Environmental Research and Human Development | Flores D.,University of Porto | Kronbauer M.A.,Centro Universitario La Salle | And 2 more authors.
Science of the Total Environment | Year: 2013

The generation of anthropogenic carbonaceous matter and mixed crystalline/amorphous mineral ultrafine/nano-particles in the 1 to 100. nm size range by worldwide coal power plants represents serious environmental problems due to their potential hazards. Coal fly ash (CFA) that resulted from anthracite combustion in a Portuguese thermal power plant was studied in this work. The physico-chemical characterization of ultrafine/nano-particles present in the CFA samples and their interaction with environment are the aim of this study. The methodologies applied for this work were field emission scanning electron microscopy (FE-SEM) with energy dispersive X-ray spectroscopy (EDS), high-resolution transmission electron microscopy with energy dispersive X-ray spectroscopy (HR-TEM/EDS) and time of flight secondary ion mass spectrometry (ToF-SIMS). Some hazardous volatile elements, C, N, S and Hg contents were also determined in the studied samples.Generally, the CFA samples comprise carbonaceous, glassy and metallic solid spheres with some containing mixed amorphous/crystalline phases. The EDS analysis coupled with the FE-SEM and HR-TEM observations of the fly ash particles with 100 to 0.1. nm demonstrates that these materials contain a small but significant proportion of encapsulated HVEs. In addition, the presence of abundant multi-walled carbon nanotubes (MWCNTs) and amorphous carbon particles, both containing hazardous volatile elements (HVEs), was also evidenced by the FE-SEM/EDS and HR-TEM/EDS analysis. A wide range of organic and inorganic compounds was determined by chemical maps obtained in ToF-SIMS analysis. © 2013 Elsevier B.V.


Sanchis J.,CSIC - Institute of Environmental Assessment And Water Research | Oliveira L.F.S.,Centro Universitario La Salle | de Leao F.B.,Centro Universitario La Salle | Farre M.,CSIC - Institute of Environmental Assessment And Water Research | And 2 more authors.
Science of the Total Environment | Year: 2015

In the present work, a new analytical approach is proposed for the analysis of seven fullerenes (C60, C70, N-methylfulleropyrrolidine, [6,6]-phenyl C61 butyric acid methyl ester, [6,6]-thienyl C61 butyric acid methyl ester, C60 pyrrolidine tris-acid ethyl ester and [6,6]-phenyl C71 butyric acid methyl ester fullerenes) in soils and sediments.This procedure combines an ultrasound-assisted solvent extraction (UAE) with toluene followed by liquid chromatography (LC), using a pyrenylpropyl group bonded silica based column, coupled to a high-resolution mass spectrometer (HRMS) using atmospheric pressure photoionisation (APPI) in negative ion mode. The analytical performance for fullerene separation of the pyrenylpropyl group bonded silica column was compared to the C18 column. For the ultra-trace analysis of fullerenes in complex environmental samples, the use of the APPI source and the use of the electrospray ionisation (ESI) source were compared.Using this approach for the analysis of fullerenes in complex matrices, a series of advantages, in terms of sensitivity and specificity, have been demonstrated. The method limits of detection (MLOD) and the method limits of quantification (MLOQ) in soils and sediments ranged from 0.022 to 0.39. pg/g and from 0.072 to 1.3. pg/g, respectively. Recoveries were between 68 and 106%.The analytical method was applied in order to assess the occurrence of selected fullerenes in 45 soils of Sul Catarinense (Santa Catalina State, Brazil) and 15 sediments from the Tubarão River, presenting different pressures of contamination: a coal-combustion power plant, car exhaust, coal mining industry and wastewater effluents. C60 and C70 fullerenes have been detected at concentrations ranging from the MLOD to 0.150ng/g. None of the functionalised fullerenes were detected in any of the samples.Combustion processes, in particular car exhaust, were identified as the main source of fullerenes. However, the potential degradation of residual concentrations of engineered fullerenes to more stable forms, such as C60 and C70, should also be considered. © 2014 Elsevier B.V.


Martinello K.,Institute of Environmental Research and Human Development | Oliveira M.L.S.,Institute of Environmental Research and Human Development | Oliveira M.L.S.,Centro Universitario La Salle | Molossi F.A.,Centro Universitario La Salle | And 5 more authors.
Science of the Total Environment | Year: 2014

This study has provided an initial assessment of the environmental impacts and potential health effects associated with coal fly ash produced during diesel co-firing. Many hazardous elements that are typically detected by multifaceted chemical characterization by XRD, petrology, FE-SEM/EDS, and HR-TEM/SEAD/FFT/EDS in ultra-fine compounds and nanominerals from the co-fired coal fly ashes (CFAs). It provided an in-depth understanding of coal ash produced during diesel co-firing. Several of the neoformed ultra-fine compounds and nano-minerals found in the coal ashes are the same as those commonly associated with oxidation/transformation of aluminosilicates, carbonates, sulphides and phosphates. © 2013 Elsevier B.V.

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