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De Campos F.,São Paulo State University | De Campos F.,University of Valencia | Iboli O.J.P.,University of Sao Paulo | Magro M.B.,CEA Saclay Nuclear Research Center | And 5 more authors.
Physical Review D - Particles, Fields, Gravitation and Cosmology | Year: 2012

Supersymmetric models with bilinear R-parity violation can account for the observed neutrino masses and mixing parameters indicated by neutrino oscillation data. We consider minimal supergravity versions of bilinear R-parity violation where the lightest supersymmetric particle is a neutralino. This is unstable, with a large enough decay length to be detected at the CERN Large Hadron Collider. We analyze the Large Hadron Collider potential to determine the lightest supersymmetric particle properties, such as mass, lifetime and branching ratios, and discuss their relation to neutrino properties. © 2012 American Physical Society.


De Campos F.,São Paulo State University | Iboli O.J.P.,University of Sao Paulo | Hirsch M.,University of Valencia | Magro M.B.,University of Sao Paulo | And 5 more authors.
Physical Review D - Particles, Fields, Gravitation and Cosmology | Year: 2010

The lightest supersymmetric particle may decay with branching ratios that correlate with neutrino oscillation parameters. In this case the CERN Large Hadron Collider (LHC) has the potential to probe the atmospheric neutrino mixing angle with sensitivity competitive to its low-energy determination by underground experiments. Under realistic detection assumptions, we identify the necessary conditions for the experiments at CERN's LHC to probe the simplest scenario for neutrino masses induced by minimal supergravity with bilinear R parity violation. © 2010 The American Physical Society.


Linhares J.J.,Federal University of Ceará | Linhares J.J.,Federal University of São Paulo | Azevedo Jr M.,Federal University of São Paulo | Siufi A.A.,Federal University of São Paulo | And 7 more authors.
BMC Medical Genetics | Year: 2012

Background: Emerging evidence has shown that miRNAs are involved in human carcinogenesis as tumor suppressors or oncogenes. Single nucleotide polymorphisms (SNPs) located in pre-miRNAs may affect the processing and therefore, influence the expression of mature miRNAs. Previous studies generated conflicting results when reporting association between the hsa-miR-196a2 rs11614913 common polymorphism and breast cancer.Methods: This study evaluated the hsa-miR-196a2 rs11614913 SNP in 388 breast cancer cases and 388 controls in Brazilian women. Polymorphism was determined by real-time PCR; control and experimental groups were compared through statistical analysis using the X2 or Fisher's exact tests.Results: The analysis of the SNPs frequencies showed a significant difference between the groups (BC and CT) in regards to genotype distribution (χ2: p = 0.024); the homozygous variant (CC) was more frequent in the CT than in the BC group (p = 0.009). The presence of the hsa-miR-196a2 rs11614913 C/T polymorphism was not associated with histological grades (p = 0.522), axillary lymph node positive status (p = 0.805), or clinical stage (p = 0.670) among the breast cancer patients.Conclusions: The results of this study indicated that the CC polymorphic genotype is associated with a decreased risk of BC and the presence of the T allele was significantly associated with an increased risk of BC. © 2012 Linhares et al.; licensee BioMed Central Ltd.


Dsouki N.A.,Centro Universitario Fundacao Santo Andre | de Lima M.P.,Centro Universitario Fundacao Santo Andre | Corazzini R.,Centro Universitario Fundacao Santo Andre | Gascon T.M.,Federal University of ABC | And 5 more authors.
Journal of Materials Science: Materials in Medicine | Year: 2014

The use of metal devices in medical application is increasing but it remains incompletely understood the physiological effects of component degradation. Niobium (Nb) alloys have already been investigated in the 1980's and recent studies demonstrated the potential of Nb as an implant material. The purpose of this study was to determine cytotoxic, hematologic and histologic effects of niobium in Swiss mice. Animals were treated with a single dose of 3 % niobium oxide (Nb2O5) diluted in PBS, i.p. Cytotoxic assay, hematologic and histologic evaluation were done 3, 7 and 12 days after niobium treatment. Data have shown increased number of cells after niobium treatment, but there was no difference in cell viability. Furthermore, it was not observed hematological modification 3, 7 or 12 days after niobium treatment. Despite the fact that animals treated with niobium for 3 and 7 days showed mild degeneration in hepatocytes, mice kept alive for 12 days showed liver cells regeneration. Our results suggested that niobium cytotoxicity was not progressive because 12 days after treatment there was an evident liver regeneration. Data obtained indicated that niobium may be promising alternatives to biomedical applications. © 2014 Springer Science+Business Media New York.


Rieg D.L.,Centro Universitario Fundacao Santo Andre | Scramim F.C.L.,Centro Universitario Fundacao Santo Andre | Raimundo D.D.O.,Centro Universitario Fundacao Santo Andre | Zau V.C.,Centro Universitario Fundacao Santo Andre | Calazans W.R.,Centro Universitario Fundacao Santo Andre
Gestao e Producao | Year: 2014

The aim of this paper is to present the application of some procedures of the situational strategic planning (SSP) to structure and solve problems in the private sector. The methodology is based on the description and analysis of three case studies. Specifically, the procedures of the explanatory and normative stages of SSP were used to explore, in the first case, the problem related to employees motivation in the quality department in an automobile company. In the second case, SSP was used to explore the problem of instability of a final product on the production assembly, in the same automobile company. In the third case, a problem related to the career plan of an instrumentation, electrical and mechanical maintenance company was explored. In all cases, the main gain in using these procedures of SSP was to provide employees with elements for deepening collective discussions on the existing problems.


Viveiros F.Z.,General Motors | Colosio M.A.,General Motors | Rossini E.L.,Centro Universitario Fundacao Santo Andre
SAE Technical Papers | Year: 2013

This work conducted an optimization in sheet metal blank's sizes for cold pressing automotive parts, comparing dimensional characteristics of automotive hood outer panels deep drawn with commonly used blank sizes for this process. As a result, it was possible to suggest modifications to smaller blank sizes, accordingly to the improvement accomplished in this work. The experimental study was conducted from observations in part's superficial aspects after its deep drawing process, which was realized in a commonly used tooling for automotive industry, with a blank's width reduction for the suggested case. The results showed a cost reduction opportunity based in this optimization. © 2013 SAE INTERNATIONAL.


Magro M.B.,Centro Universitario Fundacao Santo Andre
Journal of Physics: Conference Series | Year: 2010

We present a brief review on the features of bilinear R-parity violation in mSUGRA models at the LHC. These kind of models can provied a way of probing neutrino oscillation physics at colliders. We show that the LHC will be able to cover such models for a large fraction of the parameter space. © 2010 IOP Publishing Ltd.

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