Centro Universitario Do Para
Centro Universitario Do Para
Kataoka S.H.,University of Sao Paulo |
Setzer F.C.,University of Pennsylvania |
Fregnani E.R.,Sirio Libanes Hospital |
Pessoa O.F.,Centro Universitario Do Para |
And 2 more authors.
Journal of Endodontics | Year: 2012
Introduction: Radiation therapy (RT) of malignant tumors in the head and neck area may have damaging effects on surrounding tissues. The aim of this investigation was to evaluate the effects of RT delivered by 3-dimensional conformal radiotherapy (3D-RT) or intensity-modulated radiotherapy (IMRT) on dental pulp sensitivity. Methods: Twenty patients with oral or oropharyngeal cancer receiving RT with 3D-RT or IMRT underwent cold thermal pulp sensitivity testing (PST) of 2 teeth each at 4 time points: before RT (TP1), the beginning of RT with doses between 30 and 35 Gy (TP2), the end of RT with doses between 60 and 70 Gy (TP3), and 4 to 5 months after the start of RT (TP4). Results: All 40 teeth showed positive responses to PST at TP1 (100%) and 9 at TP2 (22.5%; 3/16 [18.8%] for 3D-RT and 6/24 [25.0%] for IMRT). No tooth responded to PST at TP3 and TP4 (0%). A statistically significant difference existed in the number of positive pulp responses between different time points (TP1 through TP4) for all patients receiving RT (P ≤.05), IMRT (P ≤.05), and 3D-RT (P ≤.05). No statistically significant differences in positive sensitivity responses were found between 3D-RT and IMRT at any time point (TP1, TP3, TP4, P = 1.0; TP2, P =.74). A statistically significant correlation existed between the location of the tumor and PST at TP2 for IMRT (P ≤.05) but not for 3D-RT (P =.14). Conclusions: RT decreased the number of teeth responding to PST after doses greater than 30 to 35 Gy. The type of RT (3D-RT or IMRT) had no influence on the pulp responses to PST after the conclusion of RT. Copyright © 2012 American Association of Endodontists.
Ribeiro A.L.R.,Centro Universitario Do Para |
Kataoka M.S.S.,Federal University of Pará |
Pinheiro J.J.V.,Federal University of Pará
Journal of Craniofacial Surgery | Year: 2014
Vascular injuries are a constant risk in facial trauma, although bone and soft tissues of the face have provided some protection to the larger blood vessels. However, penetrating injuries usually do not have this type of protection and can damage significant vascular arteries. This article presents a case of a stab wound, which led to airway obstruction arising to a large sublingual hematoma due to lingual artery injury. A healthy 44-year-old man was stabbed in the submandibular region and admitted with an airway obstruction. He was subjected to an emergency tracheotomy and evolved with progressive sublingual edema. Computed tomography (CT) angiography showed a left lingual artery injury with the formation of an expansive hematoma. The CT angiography findings helped to identify the cause of the hematoma and guided the surgery to drain the hematoma after ligation of the lingual artery. The treatment was safely performed as planned and evolved uneventfully. The patient recovered fast and well and presented normal functions 6 months after the treatment. This surgical technique is an effective method for treating such injuries because it can be safely performed when guided by CT angiography. The authors argue that the demand for vascular lesions should be routine in patients who have facial trauma. Copyright © 2014 by Mutaz B. Habal, MD.
PubMed | Sirio Libanes Hospital, University of Pennsylvania, Centro Universitario do Para and University of Sao Paulo
Type: Journal Article | Journal: Journal of endodontics | Year: 2016
Radiation therapy (RT) of malignant tumors in the head and neck area may have damaging effects on surrounding tissues. The aim of this investigation was to evaluate the long-term effects of ionizing radiation on pulp vitality by measuring pulp oxygenation levels (%SpO2) in patients with history of RT of intraoral and oropharyngeal tumors 4-6years after treatment.In an experimental group RT (n=90, history of RT) and a control group CON (n=90, no history of RT), pulp vitality was assessed by measuring %SpO2 by using pulse oximetry and pulp sensitivity by cold thermal testing. All anterior teeth without history of endodontic therapy of the participants in group RT were measured (n=693), regardless of the quadrant and the irradiated area. An equal number of anterior teeth were tested in group CON.There was no significant difference between the %SpO2 levels in group RT (92.7%; standard deviation, 1.83) and group CON (92.6%; standard deviation,1.80). All teeth in RT and CON groups showed a positive response to the thermal test. All tested teeth were considered vital.Pulp %SpO2 was found to be within normal limits 4-6years after RT. This suggests that RTmay not have a long-term influence on pulp vitality, and reported short-term changes in pulpal microcirculation because of RT may be temporary.
Phytochemical study bioassay-guided by tests of toxicity on Artemia salina and antiplasmodial activity from stem of aninga (Montrichardia linifera) [Estudo fitoquímico biomonitorado pelos ensaios de toxicidade frente à Artemia salina e de atividade antiplasmódica do caule de aninga (Montrichardia linifera)]
do Amarante C.B.,Museu Paraense Emilio Goeldi |
Muller A.H.,Centro Universitario do Para |
Povoa M.M.,Instituto Evandro Chagas |
Dolabela M.F.,Federal University of Pará
Acta Amazonica | Year: 2011
Montrichardia linifera is an aquatic plant widely use in Amazon folkmedicine. However, very little is known about the chemical composition and biological activity. In search of biologically active (s) substance (s) phytochemical bioassay-guided study was conducted evaluating hexane extract and ethanol extract obtained from stems of this species. Since only the ethanol extract presented toxicity against Artemia salina and activity against Plasmodium falciparum, this extract was selected for chromatographic fractionation. The biological activities were concentred in dichloromethane fraction which showed high toxicity against A. saline (LD 50< μg mL -1) and high antiplasmodial activity (IC 50 <10 μg mL -1), showing promising antimalarial activity. Of this fraction, the aromatic compound p-hydroxybenzaldehyde was isolated for the first time in this plant.
De Souza C.R.T.,Federal University of Pará |
de Oliveira K.S.,Federal University of Pará |
Ferraz J.J.S.,Centro Universitario do Para |
Leal M.F.,University of Sao Paulo |
And 8 more authors.
BMC Gastroenterology | Year: 2015
Background: Helicobacter pylori (HP) and Epstein-Barr virus (EBV) have been associated with cancer development. We evaluated the prevalence of HP, HP CagA + and EBV infection in gastric cancer (GC) samples from adults and in gastric tissues from patients who underwent upper endoscopy (UE). Methods: Samples from UE and GC were collected to investigate the presence of HP infection and the HP virulence factor CagA by a urease test and PCR. The presence of EBV was detected by Eber-1 in situ hybridization. Results: In UE, 85.5% of juvenile patients showed some degree of gastritis (45.3% of patients with mild gastritis and 54.7% with moderate/severe gastritis) and patients with mild gastritis were younger than patients with moderate/severe gastritis. Among adults, 48.7% presented mild gastritis and 51.3% moderate/severe gastritis. HP infection was detected in 0% of normal mucosa, 58.5% of juvenile gastritis patients, 69.2% of adult gastritis patients and 88% of GC patients. In these same groups, HP CagA + was detected in 0%, 37.7%, 61.5% and 67.2% of tissue samples, respectively. In juvenile patients, HP infection was more common in those with gastritis than in normal samples (p = 0.004). The patients with either HP or HP CagA + were older than patients without these pathogens (p < 0.05). In juvenile patients, HP infection was more frequent in cases of moderate/severe gastritis than in cases of mild gastritis (p = 0.026). Moreover, in patients with GC, HP infection was more frequent in males than in females (p = 0.023). GC patients with HP CagA + were older than patients with HP CagA - (p = 0.027). HP CagA + was more common in intestinal-type than diffuse-type GC (p = 0.012). HP CagA + was also associated with lymph-node (p = 0.024) and distal (p = 0.005) metastasis. No association between EBV infection and HP infection or any clinicopathological variable was detected. Conclusions: Our results suggest that HP is involved in the pathophysiology of severe gastric lesions and in the development of GC, particularly when CagA + is present. EBV was not the primary pathogenic factor in our samples. © 2014 de Souza et al.; licensee BioMed Central Ltd.
da Pinto D.S.,Federal University of Pará |
da Pinto D.S.,Centro Universitario do Para |
Fuzii H.T.,Federal University of Pará |
Quaresma J.A.S.,Federal University of Pará |
Quaresma J.A.S.,Pará State University
Cadernos de Saude Publica | Year: 2011
This study investigated the prevalence and risk factors for genital infection with HPV in women from rural and urban areas in two different regions of the Eastern Brazilian Amazon. A crosssectional survey was performed in Pap screening programs, with a total sample of 444 women (233 urban and 211 rural). Uterine cervical swabs were collected for the detection of HPV DNA with the established PCR assay using MY09-MY11. All volunteers answered an epidemiological questionnaire. Bivariate and multivariate logistic regression analyses were performed to identify risk factors associated with HPV infection. Overall prevalence of HPV infection was 14.6% (15% in urban women and 14.2% in rural). The only factor associated with HPV was marital status in the 13-25-year-old rural population, with higher HPV prevalence among single and divorced women and widows. The findings indicate the need for risk factor control strategies targeted specifically to women in rural and urban areas.
Figueiredo P.B.A.,Centro Universitario do Para |
Nogueira A.J.S.,Federal University of Pará
Pesquisa Brasileira em Odontopediatria e Clinica Integrada | Year: 2013
Objective: To evaluate clinically the prevalence of caries and gingivitis in children with cancer. Method: Children aged 3 to 12 years old of both genders participated in the study. Thirty-two had some type of neoplasia and 30 were healthy controls. The patients were evaluated based on the following indexes: DMFT, dmft, Plaque index (PI) and Gingival index (GI) before and 6 months after the beginning of this study. Fisher's exact and Wilcoxon tests were used in the statistical analysis to check the relations among the variables (α=0.05). Results: The most frequent neoplasia was leukemia and chemotherapy was the most common type of treatment. The dental caries indexes (DMFT and dmft) increased in both groups from baseline to the 6-month evaluation, but the difference was statistically significant only for the cancer patients. For PI and GI, no statistically significant differences were observed between the groups or between two evaluation moments. Conclusion: The results reinforce the importance of including a pediatric dentist in the multiprofessional team that treats pediatric cancer patients in order to instruct, diagnose and prevent the main oral manifestations associated with neoplasias and the treatment.
PubMed | Centro Universitario do Para and Federal University of Pará
Type: Journal Article | Journal: Revista Brasileira de terapia intensiva | Year: 2014
A study was carried out, by means of a questionnaire for guided interviews seeking to establish a profile of perceptions and oral care given by ICU nursing team to patients in intensive care units.The target population consisted of nursing practitioners divided in three education categories: nurses, nursing technicians and auxiliary nurses working at public and private hospital institutions providing for intensive care unit patients in Belem-PA. Dentistry experience has developed in this field reporting scientific findings and practical applications on prevention and reestablishment of the oral health in question.This survey disclosed results suggesting that oral hygiene care given to intensive care units patients is insufficient and inadequate requiring changes be made in the care now provided in the nosocomial environment by the nursing team.Presence of a dentist, knowledge of preventive dentistry, dissemination and use of oral hygiene specific resources are means suggested in an attempt to resolve difficulties found in oral health maintenance and treatment of oral diseases that affect the general health of hospitalized individuals. Interdisciplinary action for these individuals is advocated to achieve a better quality of life by preventing or minimizing oral pathologies.
PubMed | Centro Universitario do Para, University CEUMA and Federal University of Maranhão
Type: Journal Article | Journal: Ciencia & saude coletiva | Year: 2014
The scope of this study was to estimate the prevalence of dental spacing problems and associated factors among adolescents using data from the SB Brazil 2010 survey. The outcomes evaluated were dental spacing problems: space deficit (crowding and misalignment) and excess space (diastema and spacing) obtained using the DAI index. The association of independent variables with outcomes was assessed using a hierarchical model with four levels: contextual, socioeconomic and demographic characteristics, access to services and dental morbidity. Statistical analysis was performed using the chi-square test and univariate and multivariate Poisson distribution to estimate prevalence ratios (PR). The overall prevalence of space problems was 71.43%, with misalignment being the most common type (56.4%). The following aspects were significantly associated with excess space: age of 16, 18 and 19 years; being non-Caucasian (PR = 1.75), perception of speech problems (PR = 1.72) and periodontal pockets 4-5mm (RP = 1.56). For space deficit: family income up to 3 minimum wages, dental visit 1 year or more previously (PR = 1.19) and having one or more decayed teeth on average (PR = 1.32). There was a prevalence of spacing problems, especially with socioeconomic and demographic variables and morbidity as potential risk factors.
PubMed | Centro Universitario do Para and Federal University of São Paulo
Type: Journal Article | Journal: Revista do Colegio Brasileiro de Cirurgioes | Year: 2015
to evaluate the incidence of unfavorable outcomes in vascular trauma patients and their possible correlation to the distance between the city where the injury was sustained and the hospital where the patient received definitive treatment.descriptive and retrospective study. Data were collected from medical records of patients submitted to surgical procedures for arterial or venous injuries from February 2011 to February 2013 at the only trauma center providing vascular surgery in a vast area of the Amazon region. Trauma date, patient gender and age, mechanism and anatomic topography of injury, surgical management, need for surgical re-intervention, hospitalization period, postoperative complications, mortality and limb amputation rates were analyzed. The incidence of unfavorable outcomes was assessed according to the distance between the city where the vascular injury was sustained and the trauma center.One hundred seventy-three patients with 255 vascular injuries were analyzed; 95.95% were male (p<0.05), mean age of 28.92 years; 47.4% were caused by firearm projectiles (p<0.05); topographic distribution: 45.66% lower limbs (p<0.05), 37.57% upper limbs, 6.94% abdominal, 5.2% thoracic and 4.62% were cervical vascular injuries; 51.42% of patients required hospitalization for seven days or less (p<0.05); limb amputation was necessary in 15.6% and the overall mortality was 6.36%.distances greater than 200 Km were associated to longer hospitalization period; distances greater than 300 Km were associated to increased limb amputation probability; severe vascular trauma have an increased death probability when patients need to travel more than 200 Km for surgical treatment.