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de Lucca R.M.R.,Federal University of Mato Grosso | Batista Junior J.,Centro Universitario do Distrito Federal | Fontes C.J.F.,Federal University of Mato Grosso | Fontes C.J.F.,Hospital Universitario Julio Muller | And 2 more authors.
Environmental and Molecular Mutagenesis | Year: 2015

Lumefantrine (LF) is an aryl-amino alcohol antimalarial drug used in artemisinin-based combination therapies against malaria worldwide. In this study, we investigated the genotoxic effects of LF in human lymphocytes in vitro, and the potential noncovalent interaction of LF with DNA using a 3D DNA-docking model. The number of DNA breaks and the frequency of nuclear buds (NBUDS) was significantly increased (P<0.01 and P <0. 05, respectively) at LF concentrations of 60, 80, and 100 μg/mL (LF60, LF80, and LF100, respectively). Frequency (‰) of micronuclei (MN) formation also increased after LF treatments. However, this was only significant for LF100 (P = 0.01) and LF80 (P = 0.001). LF did not affect the frequency of nucleoplasmic bridges (NPBs) (P = 0.12) or the nuclear division index (NDI) (P = 0.32). Computational analysis suggests that LF may interact noncovalently with DNA via the DNA minor groove surface with a predicted binding affinity energy of -7.2 kcal/mol and showing a favorable shape complementary to this groove. Our results suggest that LF has clastogenic effects in human lymphocytes in vitro due to noncovalent interaction with the minor groove of DNA. Environ. Mol. Mutagen. 56:556-562, 2015. © 2015 Wiley Periodicals, Inc. Source

Do Prado H.A.,Catholic University of Brasilia | Campos F.B.,Catholic University of Brasilia | Ferneda E.,Catholic University of Brasilia | Cornelio N.N.,Federal Bureau of Data Processing | And 2 more authors.
Frontiers in Artificial Intelligence and Applications | Year: 2012

Advances in information technology have made possible ac-cumulation of large amount of data arising from information systems. This fact enabled the emergence and growth of research on Data Min-ing (DM), which aims primarily at identifying new and useful patterns in databases. Recently, software quality has received attention among areas of application. The quality of software has become an important issue for the maintenance and customer attraction for businesses and can be considered a competitive weapon. On the other hand, the quality of decision making in project management software is closely related to information available about the process of organizational development. This information can be stored in data warehouses to be analyzed and interpreted using techniques of DM. This paper describes an application of DM bases of quality metrics for software products, which are aimed at identifying the variables of the development process that would mostly affect the error rate during the phases of testing, approval, and production. The study of the target company has a high level of stand-ardization of processes. The results obtained in the models indicated a strong or moderate correlation of some variables of the process with product quality, which may be the target of management attention in order to: (i) improve the overall quality of the development process, (ii) Advances in Knowledge-Based and Inreduce the error rate in the systems developed and (iii) promote greater customer satisfaction. © 2012 The authors and IOS Press. All rights reserved. Source

Do Prado H.A.,Catholic University of Brasilia | Bianchi Campos F.,Catholic University of Brasilia | Ferneda E.,Catholic University of Brasilia | Nunes Cornelio N.,Federal Bureau of Data Processing | And 2 more authors.
Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) | Year: 2013

Since the arising of software engineering many efforts have been devoted to improve the software development process. More recently, software quality has received attention from researchers due to the importance that software has gained in supporting all levels of the organizations. New methods, techniques, and tools were created to increase the quality and productivity of the software development process. Approaches based on the practitioners' experience, for example, or on the analysis of the data generated during the development process, have been adopted. This paper follows the second path by applying data mining procedures to figure out variables from the development process that most affect the software quality. The premise is that the quality of decision making in management of software projects is closely related to information gathered during the development process. A case study is presented in which some regression models were built to explore this idea during the phases of testing, approval, and production. The results can be applied, mainly, to help the development managers in focusing those variables to improve the quality of the software as a final product. © 2013 Springer-Verlag. Source

Carvalho Rodrigues M.A.,Centro Universitario do Distrito Federal | Santos N.A.G.D.,University of Sao Paulo | Da Silva Faria M.C.,Federal University of Sao Paulo | Rodrigues J.L.,Federal University of Sao Paulo | And 6 more authors.
Chemico-Biological Interactions | Year: 2016

Cisplatin (Cisp) is an effective antitumor drug; however, it causes severe nephrotoxicity. Minimization of renal toxicity is essential, but the interference of nephroprotective agents, particularly antioxidants, with the antitumor activity of cisplatin is a general concern. We have recently demonstrated that the anti-hypertensive and antioxidant drug carvedilol (CV) protects against the renal damage and increases the survival of tumor-bearing mice without impairing the tumor reduction by cisplatin. So far, reports on the antioxidant mechanism of CV are controversial and there are no data on the impact of CV on the antitumor mechanisms of cisplatin. Therefore, this study addresses the effect of CV on mechanisms underlying the tumor control by cisplatin. CV did not interfere with the biodistribution or the genotoxicity of cisplatin. We also addressed the antioxidant mechanisms of CV and demonstrated that it does not neutralize free radicals, but is an efficient chelator of ferrous ions that are relevant catalyzers in cisplatin nephrotoxicity. The present data suggest that oxidative damage and genotoxicity play different roles in the toxicity of cisplatin on kidneys and tumors and therefore, some antioxidants might be safe as chemoprotectors. Altogether, our studies provide consistent evidence of the beneficial effect of CV on animals treated with cisplatin and might encourage clinical trials. © 2016 Elsevier Ireland Ltd. All rights reserved. Source

Tibana R.A.,Catholic University of Brasilia | Nascimento D.C.,Catholic University of Brasilia | Sousa N.M.F.,Laboratorio Of Fisiologia Do Exercicio E Medidas E Avaliacao | Silva R.A.S.,Catholic University of Brasilia | And 4 more authors.
Revista Brasileira de Cineantropometria e Desempenho Humano | Year: 2014

The aim of the present study was to analyze the response of systolic (SBP) and diastolic (DBP) blood following three experimental sessions: resistance exercise (RE), combined exercise (COMB-aerobic and RE) and control session (CON). Thirty women with metabolic syndrome (MS) were randomly assigned to one of three experimental groups: RE (n=10; 36.1 ± 9.0 years) (3 sets of 8-12 repetitions at 80% of 10RM in six exercises for whole body); COMB (n=10; 33.1 ± 5.0 years) (30 min of aerobic exercise at 65-70% of reserve heart rate which was followed by the same RE session) and CON (n=10; 30.4 ± 6.6 years). The SBP and DBP were measured before and every 15 min during 60 min following the experimental sessions. The COMB group presented greater delta SBP (ΔSBP) decrease at 15, 30 and 45 min post-exercise as compared with CON group (p <0.05); the RE group presented greater ΔSBP reduction at 30 and 45 min post-exercise also compared with CON group (p <0.05). In addition, the area under the curve of ΔSBP for COMB group (~30 mmHg of hypotension during 60 min, p ≤ 0.0005) and RE group (~19 mmHg of hypotension during 60 min, p = 0.024) were greater than the CON group. Therefore, RE and COMB elicited post-exercise hypotension in women with MS; COMB provided a greater decrease which may be of value in the prevention and treatment of cardiovascular disorders. Source

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