Fernandes B.J.D.,University of Sao Paulo |
Miranda Silva C.D.,University of Sao Paulo |
Andrade J.M.,University of Sao Paulo |
Matthes A.D.C.S.,Centro Universitario Barao Of Maua |
And 2 more authors.
Cancer Chemotherapy and Pharmacology | Year: 2011
Purpose: Adjuvant chemotherapy with cyclophosphamide (CYC) is used for the treatment of breast cancer. CYC is used as a racemic mixture, although preclinical data have demonstrated differences in the efficacy and toxicity of its enantiomers, with (S)-(-)-CYC exhibiting a higher therapeutic index. The present study investigated the enantioselectivity and influence of CYP2B6, CYP2C9, CYP2C19, and CYP3A on the kinetic disposition of CYC in patients with breast cancer. Methods: Fifteen patients previously submitted to removal of the tumor and treated with racemic CYC (900 or 1,000 mg/m 2) and epirubicin were included in the study. The in vivo activity of CYP3A was evaluated using midazolam as a marker drug. Serial blood samples were collected up to 24 h after administration of the first cycle of CYC. Results: The kinetic disposition of CYC was enantioselective in patients with breast cancer, with plasma accumulation of the (S)-(-)-CYC enantiomer (AUC 195.0 vs. 174.8 μg h/mL) due to the preferential clearance of the (R)-(+)CYC enantiomer (5.1 vs. 5.7 L/h). Clearance of either CYC enantiomer did not differ between the CYP2B6, CYP2C9, and CYP2C19 genotypes or as a function of the in vivo activity of CYP3A evaluated by midazolam clearance. Conclusions: The pharmacokinetics of CYC is enantioselective in patients with breast cancer concomitantly treated with epirubicin and ondansetron. Genotyping or phenotyping did not contribute to adjustment of the CYC dose regimen in patients included in this study. © 2011 Springer-Verlag.
Cognitive deficits in chronic pain patients, in a brief screening test, are independent of comorbidities and medication use [Déficits cognitivos em pacientes com dor crônica, em uma avaliação breve de triagem, são independentes de comorbidades e uso de medicações]
Dos Santos Ferreira K.,University of Sao Paulo |
Dos Santos Ferreira K.,Centro Universitario Barao Of Maua |
Oliver G.Z.,Centro Universitario Barao Of Maua |
Thomaz D.C.,Centro Universitario Barao Of Maua |
And 2 more authors.
Arquivos de Neuro-Psiquiatria | Year: 2016
Objective: To describe and analyze cognitive aspects in patients with chronic pain and a control group without pain. Method: A case-control study was conducted on 45 patients with chronic pain and on 45 control subjects. Data including pain diagnosis, comorbidities and medication used, were evaluated. Cognitive tests, such as the Montreal Cognitive Assessment (MoCA), Verbal Fluency Test, Clock Drawing Test and Stroop Test, were applied. Results: Patients with chronic pain showed a poorer performance, as shown by the scores of the MoCA test (p < 0.002), Verbal Fluency Test (p < 0.001), Clock Drawing Test (p = 0.022) and Stroop Test (p < 0.000). Chronic pain variable (p = 0.015, linear regression model) was an independent factor for results obtained with the MoCA. Conclusion: Patients with chronic pain showed a poorer performance in a brief screening test for cognitive impairment not related to confounding variables, as comorbidities and pain-medication use. © 2016, Associacao Arquivos de Neuro-Psiquiatria. All rights reserved.
Rosset I.,University of Sao Paulo |
Roriz-Cruz M.,Federal University of Rio Grande do Sul |
Santos J.L.F.,University of Sao Paulo |
Haas V.J.,University of Sao Paulo |
And 2 more authors.
Revista de Saude Publica | Year: 2011
Objective: To identify demographic and socioeconomic differentials associated with the health status of oldest-old individuals living in two cities of different Brazilian regions. Methods: A comparative and cross-sectional epidemiological study was conducted with the oldest-old (≥ 80 years), living in the cities of Ribeirão Preto (RP, Southeastern Brazil) and Caxias do Sul (CS, Southern). The probabilistic sample included 117 individuals in CS and 155 in RP, and data were collected between 2007 and 2008. The instrument included demographic and socioeconomic data, Mini-Mental State Examination, Functional Independence Measure, number of self-reported comorbidities and Geriatric Depression Scale. Results: Mean age was similar, with predominance of women (~70%) and widowed individuals (~60%) in both cities. Mean level of education did no differ statistically, although mean income was higher in RP than in CS (p = 0.05). RP showed a higher concentration of individuals in the extreme levels of education and income than that of CS. Mean score of the Mini-Mental State Examination was similar in both groups and higher among men, individuals aged between 80 and 84 years, married and with a higher level of education. Better functional performance was observed in elderly individuals aged between 80 and 84 years in both cities, in those with higher level of education in RP; and in males and married individuals in CS. Elderly individuals in CS showed higher number of comorbidities than those in RP (p < 0.001). Male elderly individuals, married and with -higher income level showed fewer depressive symptoms in both groups; and those in RP showed higher Geriatric Depression Scale score than the others in CS (p < 0.001). Conclusions: Although the oldest old in CS showed lower socioeconomic inequality and fewer depressive symptoms, they also had a higher mean number of comorbidities and lower level of functional independence, when compared to those in RP. © Faculdade de Saúde Pública da Universidade de São Paulo.
Rodrigues R.A.P.,University of Sao Paulo |
Marques S.,University of Sao Paulo |
Kusumota L.,University of Sao Paulo |
dos Santos E.B.,University of Sao Paulo |
And 2 more authors.
Revista Latino-Americana de Enfermagem | Year: 2013
Objective: to examine the transition of care in families caring for elderly persons who suffered the first episode of a cerebrovascular accident. Methodology: an instrumental ethnographic case study was used. The sample comprised 20 subjects: 10 caregivers and 10 elderly persons aged 65 or over, of both sexes, with diagnoses of first episode of cerebrovascular accident, capable of communicating, and requiring care from a main carer in their family. The data was collected through interviews, observation, existing documentation and field notes. Qualitative analysis techniques were used to codify and classify the data and to formulate significant categories, which generated typologies of care. Results and Discussion: The central idea was the Transition of Care and showed the context in three typologies: The care process for the dependent elderly person, Strategies for the care process and Impact and acceptance of the limitations. Conclusion: The data indicates that caring for an elderly person after a cerebrovascular accident is a challenge for the family. The data permitted it possible to elaborate a proposal for a model for the organization of the work, with a view to holistic care delivery in the health services, forming a care network, which constitutes an advance for the area of nursing.
Pezolato A.,University of Sao Paulo |
De Vasconcelos E.E.,Centro Universitario Barao Of Maua |
Defino H.L.A.,University of Sao Paulo |
Defino A.,University of Sao Paulo |
Nogueira-Barbosa M.H.,University of Sao Paulo
European Spine Journal | Year: 2012
Aim Decreased activity of the lumbar stabilizer muscles has been identified in individuals with sway-back posture. Disuse can predispose these muscles to atrophy, which is characterized by a reduced cross-sectional area (CSA) and by fat infiltration. The aim of this study was to evaluate the amount of fat infiltration in the lumbar multifidus and lumbar erector spinae muscles as a sign of the muscle atrophy in individuals with sway-back posture, with and without low back pain. Materials and methods Forty-five sedentary individuals between 16 and 40 years old participated in this study. The sample was divided into three groups: symptomatic swayback (SSBG) (n = 15), asymptomatic sway-back (ASBG) (n = 15), and control (CG) (n = 15). The individuals were first subjected to photographic analysis to classify their postures and were then referred for a magnetic resonance imaging (MRI) examination of the lumbar spine. The total (TCSA) and functional (FCSA) cross-sectional areas of the lumbar erector spinae together with lumbar multifidus and isolated lumbar multifidus muscles were measured from L1 to S1. The amount of fat infiltration was estimated as the difference between the TCSA and the FCSA. Results Greater fat deposition was observed in the lumbar erector spinae and lumbar multifidus muscles of the individuals in the sway-back posture groups than in the control group. Pain may have contributed to the difference in the amount of fat observed in the groups with the same postural deviation. Similarly, sway-back posture may have contributed to the tissue substitution relative to the control group independently of low back pain. Conclusions The results of this study indicate that individuals with sway-back posture may be susceptible to morphological changes in their lumbar erector spinae and lumbar multifidus muscles, both due to the presence of pain and as a consequence of their habitual posture. © 2012- Springer-Verlag.
PubMed | Centro Universitario Barao Of Maua and University of Sao Paulo
Type: Journal Article | Journal: Arquivos de neuro-psiquiatria | Year: 2016
Objective To describe and analyze cognitive aspects in patients with chronic pain and a control group without pain. Method A case-control study was conducted on 45 patients with chronic pain and on 45 control subjects. Data including pain diagnosis, comorbidities and medication used, were evaluated. Cognitive tests, such as the Montreal Cognitive Assessment (MoCA), Verbal Fluency Test, Clock Drawing Test and Stroop Test, were applied. Results Patients with chronic pain showed a poorer performance, as shown by the scores of the MoCA test (p < 0.002), Verbal Fluency Test (p < 0.001), Clock Drawing Test (p = 0.022) and Stroop Test (p < 0.000). Chronic pain variable (p = 0.015, linear regression model) was an independent factor for results obtained with the MoCA. Conclusion Patients with chronic pain showed a poorer performance in a brief screening test for cognitive impairment not related to confounding variables, as comorbidities and pain-medication use.
PubMed | Centro Universitario Barao Of Maua and University of Sao Paulo
Type: Journal Article | Journal: Revista brasileira de enfermagem | Year: 2016
to present the concept of needs according to different approaches to discuss the possibility of health care that incorporates a broader view of human vulnerabilities in health services.the arguments are founded on nursing theorists who worked on the construction of frameworks relevant to care, based on needs and on philosophers who show the possibility of identifying the vulnerabilities of human beings, defending art as a therapeutic instrument that can promote health care.although care can acquire a new dimension with the introduction of art, according to certain perspectives, philosophical studies on ethics and aesthetics should be resumed to identify human vulnerabilities that can in fact be compensated by sensible understanding of the outer world. To incorporate art in nursing care requires studies from theorists to be recovered, deepening concepts and working on empirical investigations for their adequate use.
Benassi V.M.,University of Sao Paulo |
Pasin T.M.,Centro Universitario Barao Of Maua |
Facchini F.D.A.,University of Sao Paulo |
Jorge J.A.,University of Sao Paulo |
De Moraes Polizeli M.L.T.,University of Sao Paulo
Journal of Basic Microbiology | Year: 2014
This study investigates the production of glucoamylase from Aspergillus phoenicis in Machado Benassi (MB) medium using 1% maltose as carbon source. The maximum amylase activity was observed after four days of cultivation, on static conditions at 30°C. Glucoamylase production was induced by maltose and inhibited by different glucose concentrations. The optimum of temperature and pH were 60-65°C, and 4.5 or 5.0 to sodium acetate and Mcllvaine buffers, respectively. It was observed that the enzyme was totally stable at 30-65°C for 1h, and the pH range was 3.0-6.0. The enzyme was mainly activated by manganese (176%), and calcium (130%) ions. The products of starch hydrolysis were analyzed by thin layer chromatography and after 3h, only glucose was detected, characterizing the amylolytic activity as a glucoamylase. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
PubMed | Centro Universitario Barao Of Maua, Federal University of Rio Grande do Norte and University of Sao Paulo
Type: Journal Article | Journal: Molecules (Basel, Switzerland) | Year: 2016
Oil-in-water nanoemulsions are stable systems with droplet sizes in the 20-200 nm range. The physicochemical properties of these systems may be influenced by the addition of additives. Thus, the influence of ethoxylated (EL) and acetylated lanolin (AL) addition on the droplet size, pH values, electrical conductivity and stability of nanoemulsions was investigated. Then, effect of nano-emulsions additives with EL (NE-EL) or AL (NE-AL) in hydration, oiliness and pH of the skin were evaluated. Nanoemulsion safety was evaluated through the observation of no undesirable effects after skin formulation application. Both additives caused changes in droplet size and electrical conductivity, but not in pH values. Nanoemulsions containing up to 6.0% ethoxylated lanolin and 2.0% acetylated lanolin remained stable after centrifugation tests. Higher concentrations of the additives made the nanoemulsions unstable. Stability tests showed that ethoxylated lanolin produced more stable nanoemulsions then acetylated lanolin and that the major instability phenomenon occurring in these systems is coalescence at elevated temperatures. Nanoemulsion-based lanolin derivatives increased skin hydration and oiliness and did not change cutaneous pH values. These formulations are non-toxic since they did not cause any irritation on the skin surface after nanoemulsion application, showing potential as carriers for pharmaceuticals and cosmetic applications.
Rossi E.G.,Federal University of São Paulo |
Abib J.C.,Federal University of São Paulo |
Rodrigues L.A.,Centro Universitario Barao Of Maua
Communications in Computer and Information Science | Year: 2015
Communication is a basic need of human beings. It is required in professional, social and personal relationships, establishing a fundamental aspect for survival. Communication can be considered a set of signs that refers to behaviors that occur among two or more persons and which provide a way to create meanings between them. When individuals have no forms of communication or have some form of communication, but this is not enough to maintain communication links, establishing social relationships, it is necessary to use some resources to promote communication, integrating this individual in social life. Adapt and create alternative ways of communication is essential for people with disabilities or lack of oral communication to interact with their peers into the work, social and personal environments. For these adaptations it is common to use alternative and augmented communication tools (AACT), for example, uses of alternative communication boards and applications to support the communication process, using images, videos and technological resources to support the communication. The objective of this research is propose the development of prototypes with medium fidelity to facilitate patients with disabilities to learn and communicate, and understanding their distinctions in learning and interacting during communication process. © Springer International Publishing Switzerland 2015.