Resik S.,Instituto Pedro Kouri |
Tejeda A.,Centro Provincial Of Higiene |
Mach O.,World Health Organization |
Fonseca M.,Instituto Pedro Kouri |
And 6 more authors.
Vaccine | Year: 2015
Introduction: The World Health Organization recommends that, as part of the new polio endgame, a dose of inactivated poliovirus vaccine (IPV) be introduced by the end of 2015 in all countries using only oral poliovirus vaccine (OPV). Administration of fractional dose (1/5th of full dose) IPV (fIPV) intradermally may reduce costs, but its administration is cumbersome with BCG needle and syringe. We evaluated performance of two newly developed intradermal-only jet injectors and compared the immune response induced by fIPV with that induced by full-dose IPV. Methods: Children between 12 and 20 months of age, who had previously received two doses of OPV, were enrolled in Camaguey, Cuba. Subjects received a single dose of IPV (either full-dose IPV intramuscularly with needle and syringe or fIPV intradermally administered with one of two new injectors or with BCG needle or a conventional needle-free injector). Serum was tested for presence of poliovirus neutralizing antibodies on day 0 (pre-IPV) and on days 3, 7 and 21 (post-vaccination). Results: Complete data were available from 74.2% (728/981) subjects. Baseline median antibody titers were 713, 284, and 113 for poliovirus types 1, 2, and 3, respectively. Seroprevalence at study end were similar across the intervention groups (≥94.8%). The immune response induced with one new injector was similar to BCG needle and to the conventional injector and superior to the other new injector. fIPV induced significantly lower boosting response compared to full-dose IPV. No safety concerns were identified. Interpretation: One of the two new injectors demonstrated its ability to streamline intradermal fIPV administration, however, further investigations are needed to assess the potential contribution of fIPV in the polio endgame plan. © 2014 Elsevier Ltd.
Gonzalez G.S.G.,Centro Provincial Of Higiene |
Perez I.M.S.,Hospital Clinico Quirurgico Docente Provincial Manuel Ascunce Domenech Of Camaguey |
Lana L.R.,Hospital Clinico Quirurgico Docente Provincial Manuel Ascunce Domenech Of Camaguey |
de Leon Avila I.P.,Centro Provincial Of Higiene
Revista Cubana de Medicina Tropical | Year: 2012
Introduction: the clinical manifestations of brucellosis have been poorly researched on and the symptoms and possible complications have not been deeply studied either. Objective: to report a case of infective endocarditis caused by brucellosis for the first time in Cuba. Methods: a Caucasian male farmer aged 57 years was referred from Vertientes municipality to be admitted at "Manuel Ascunce Domenech" provincial hospital in Camaguey province in December,2009. He had been presumptively diagnosed with infectious endocarditis caused by Brucella and with moderate aortic failure since he presented with fever, general malaise, fatigue, muscle and joint pains, arthritis, marked asthenia, anorexia, neurological signs, sweating and strong chest pain. In his previous hospitalization, he had been treated with antimicrobials after indication of supplementary tests such as slow serology for brucellosis; however, specific reagents were not available,so these tests were not performed until January 2010.The epidemiological history of this case included his direct contact with cows and pigs as well as wounds and minor traumas inflicted on his hands and feet resulting from his type of work. His farm is next to another farm where the cattle is also affected with brucellosis. Results: the lab tests were positive with high serological titres, and although it was not possible to isolate the etiologic agent through culturing, the disease and the infective endocarditis were serologically confirmed as additional complication; this required antimicrobial treatment and drugs for the heart disease. These complications from brucellosis are barely diagnosed in the international literature, and in Cuba, this is the first report of the disease. Conclusions: the description of this case is an alert to diagnosis of infective endocarditis that may be associated with epidemiological history of brucellosis.
Practical method for diagnosis and control of an outbreak of nosocomial infection at the neonatology service [Método práctico para el diagnóstico y control de un brote de infección intrahospitalaria en un servicio de neonatología]
Gonzalez J.L.A.,Centro Provincial Of Higiene
Revista Cubana de Salud Publica | Year: 2011
Objective To present the steps followed for the diagnosis and control of an outbreak of the neonatology service of "Vladimir Ilich Lenin" hospital in Holguín province during October and November. The universe of study was 27 newborns who were hospitalized during the length of time of this study; 15 of them were diagnosed as generalized nosocomial sepsis patients. For the study, diagnosis and confirmation of the outbreak, the steps set by the National Program of Prevention and Control of Nosocomial Infections of the Cuban Ministry of Health were followed. Results The outbreak had multifactoral cause. It was confirmed that infection in 11 newborns was caused by Serratia mascescens germ. Three of them died. The rate of acquired generalized sepsis in the epidemic period was 33.3 per 100 admittances, much higher than that of the endemic period six months before, which amounted to 5.6 per 100 admittances. Girls prevailed and the average age was 2-7 days. Conclusions It was proved that the National Program of Prevention and Control is very useful and effective as a working tool in the hospitals and, particularly in the neonatology services where there are high risk of occurrence of outbreak of nosocomial infection causing high infant morbidity and mortality.
Canete R.,Centro Provincial Of Higiene |
Guilhem D.,University of Brasilia |
Brito K.,Policlinica Samuel Fernandez
Acta Bioethica | Year: 2012
Informed consent constitutes a crucial link in research involving human beings. Nevertheless, knowledge limitations which lead to errors of its process and application have been frequently identified by professionals globally. Hence, a brief review of the topic is exposed about the concept and the elements related to adequate process and application, which we belief will allow to clarify the information that professionals who do research involving human beings posses.
Fimia Duarte R.,Centro Provincial Of Higiene
Revista cubana de medicina tropical | Year: 2010
the study carried out in Yaguajay, Sancti Spíritus province was aimed at identifying the mollusk species present in the freshwater ecocystems as well as their distribution and abundance in each reservoir. two years--2005 and 2006--were analyzed through 2 samplings per years covering the rainy and the dry season; 20 reservoirs were sampled to determine the present freshwater mollusks. Data were processed by Excelxp and the statistical analysis used SPSS version 8 processor and 4 x 4 contingency tables. ten species were detected in 2005, being Tarebia granifera the most distributed and abundant followed by Marisa cornuarietis. It was observed that the highest amount of mosquitoes was collected in the rainy season during the two years under study in addition to proving that there was significant correlation between the occurrence of mollusk species and fish in the 20 researched reservoirs. Yaguajay municipality exhibits wide freshwater mollusk fauna if one takes into account the 14 identified species of which 4 turned out to be intermediate hosts for fascioliasis, schistosomiasis and angiostrongyliasis. There is close relation between freshwater malacofauna and vegetation.
[Season and weather-dependent behavior of Aedes aegypti (Diptera: Culicidae) mosquitoes in Sancti Spiritus in the period 1999-2007]. [Comportamiento estacional y temporal de Aedes aegypti (Diptera: Culicidae) en Sancti Spíritus, 1999-2007.]
Cruz Pineda C.A.,Centro Provincial Of Higiene
Revista cubana de medicina tropical | Year: 2010
Aedes aegypti is the main dengue and hemorrhagic dengue vector and its widespread behavior responds to a number of factors, among them, the climatic ones. to determine the behavior of Aedes aegypti mosquitoes depending on season and weather conditions and how it relates with climatic factors such as temperature and rain. a descriptive seasonal and weather study was made on the basis of data given by the provincial weather center and the surveillance anti-vector fight unit located in Sancti Spiritus province, which covered the 1999-2007 period. of the total number of samples, 86.7% comprised immature phases of the mosquito whereas 13.2% corresponded to mosquitoes at the adult phase; 19.2% of foci were found inside houses and premises but 80.7% outdoors. The highest focal incidence occurred in 2001 (278 foci) and in 2005 (219 foci) whereas the lowest incidence was found in 1999 (14 foci) and in 2003 (32 foci). The municipalities with the highest numbers of foci were Trinidad (302), Sancti Spiritus (242), Cabaiguán (241) and Jatibonico (154) and the lowest figures went to Yaguajay (13) and La Sierpe (6). The number of foci in the rainy season was significant with respect to the dry season (t = 4.09; p = 0.04). There was not high correlation between the number of foci and the recorded temperatures in the course of the study. it was shown that keeping permanent surveillance on Aedes aegypti is extremely important to prevent introduction and spread of this species into the province, mainly in the rainy periods.
Lopez Aday D.,Hospital Clinico Quirurgico Docente Celestino Hernandez Robau |
Rivero Alvarez E.,Centro Provincial Of Higiene |
Martinez Torres A.,Centro Provincial Of Higiene |
Milagros Alegret Rodriguez C.,University of Medical Sciences of Costa Rica
Revista Cubana de Higiene y Epidemiologia | Year: 2013
Introduction: foodborne diseases are, according to the World Health Organization, one of the most widespread problems in the present world and an important cause for the decrease in productivity in countries, enterprises, families and individuals. Methods: a retrospective descriptive observational study of foodborne diseases in Villa Clara was conducted for the period 2004 2008 in order to characterize them. 371 reported outbreaks were processed and all the information was obtained thorough epidemiological surveillance. The variables used were: incidence of outbreaks, type of outbreaks, place of occurrence, implicated food and causative agent. The methods used were absolute frequencies, percentages, incidence rates and chi-square. Results: the most frequent outbreaks were the ones caused by food and meat and sausage were identified as the main causative agents. The houses were the places where they most frequently occurred. State origin predominated. Conclusions: the main causative agent of foodborne diseases was the Staphylococcus aureus.
Proposal and evaluation of a statistical model for the quality control of veneral disease research laboratories/rapid plasma reagin serologies [Propuesta y evaluación de un modelo estadístico para el control de la calidad de las serologías VDRL/RPR]
de Escobar Martin H.R.,Centro Provincial Of Higiene |
Hernandez del Sol C.,Centro Provincial Of Higiene |
Sanchez Alvarez M.L.,Centro Provincial Of Higiene |
Pastrana Tapia A.C.,Centro Provincial Of Higiene |
Rodriguez Gonzalez I.,Institute Medicina Tropical Pedro Kouri
Revista Cubana de Medicina Tropical | Year: 2013
Introduction: the purpose of every quality control laboratory for the serological diagnosis of syphilis is to monitor the accuracy of test performance. Objective: to evaluate the proposal of a statistical model to tabulate the results of the laboratories involved in the quality control of the veneral disease research laboratories-rapid plasma reagin serology for the assessment of and customized attention to them. Methods: a model for the collection of information from the 21 laboratories of Villa Clara's provincial network in the 2006-2010 period was designed and refined until the final version was reached. The defined variables comprised Number of sent sera, Total discordant, Nonreactive Discordant, Reactive Discordant, Shipping by month and Final evaluation were defined. Evaluation criteria were set for each variable. This paper presented the evaluation of the model with information from January to March, 2011. Results: the suggested model allowed the detection of the main difficulties such as the non-compliance with the number of sent sera, non-reception of samples monthly and also current conflicting results. The model is fair when making evaluation, since it uses generalized quantitative criteria that enable individualized qualitative assessment and it is also in line with current evaluative techniques applied in different fields of social endeavor. Conclusions: the statistical model allows provincial quality control laboratory to tabulate data by using the suggested variables and thus evaluate each laboratory in Villa Clara.
Noda Albelo A.L.,Hospital Pediatrico Eliseo Noel Caamano |
Vidal Tallet L.A.,Hospital Pediatrico Eliseo Noel Caamano |
Perez Lastre J.E.,Institute Medicina Tropical Pedro Kouri |
Canete Villafranca R.,Centro Provincial Of Higiene
Revista Cubana de Medicina | Year: 2013
The main consequence of persistent replication of the human immunodeficiency virus is the gradual reduction of CD4 positive T lymphocytes, what eventually leads to the loss of immunological competence. The CD4 positive T lymphocytes count by means of flow cytometry is considered an essential part in medical attention and a parameter to identify the disease as well as a useful guide to clinical treatment. Numerous factors, besides the infection by the human immunodeficiency virus, can influence in the CD4 positive T lymphocytes. The changes in this parameter, generated by these factors, do not indicate real modifications in the immunological status of the patient and should be interpreted with caution.
PubMed | Centro Provincial Of Higiene
Type: Journal Article | Journal: Revista cubana de medicina tropical | Year: 2013
Aedes aegypti is the main dengue and hemorrhagic dengue vector and its widespread behavior responds to a number of factors, among them, the climatic ones.to determine the behavior of Aedes aegypti mosquitoes depending on season and weather conditions and how it relates with climatic factors such as temperature and rain.a descriptive seasonal and weather study was made on the basis of data given by the provincial weather center and the surveillance anti-vector fight unit located in Sancti Spiritus province, which covered the 1999-2007 period.of the total number of samples, 86.7% comprised immature phases of the mosquito whereas 13.2% corresponded to mosquitoes at the adult phase; 19.2% of foci were found inside houses and premises but 80.7% outdoors. The highest focal incidence occurred in 2001 (278 foci) and in 2005 (219 foci) whereas the lowest incidence was found in 1999 (14 foci) and in 2003 (32 foci). The municipalities with the highest numbers of foci were Trinidad (302), Sancti Spiritus (242), Cabaigun (241) and Jatibonico (154) and the lowest figures went to Yaguajay (13) and La Sierpe (6). The number of foci in the rainy season was significant with respect to the dry season (t = 4.09; p = 0.04). There was not high correlation between the number of foci and the recorded temperatures in the course of the study.it was shown that keeping permanent surveillance on Aedes aegypti is extremely important to prevent introduction and spread of this species into the province, mainly in the rainy periods.