Centro Oncologico Estatal ISSEMYM

Mexico City, Mexico

Centro Oncologico Estatal ISSEMYM

Mexico City, Mexico
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Flores-Fernandez J.M.,Research Center istencia En Tecnologia seno Del Estado Of Jalisco | Herrera-Lopez E.J.,Research Center istencia En Tecnologia seno Del Estado Of Jalisco | Sanchez-Llamas F.,Opd Antiguo Hospital Civil Of Guadalajara Fray Antonio Alcalde | Rojas-Calvillo A.,Centro Oncologico Estatal ISSEMYM | And 5 more authors.
Expert Systems with Applications | Year: 2012

Lung cancer is a public health priority worldwide due to the high mortality rate and the costs involved. Early detection of lung cancer is important for increasing the survival rate, however, frequently its diagnosis is not made opportunely, since detection methods are not sufficiently sensitive and specific. In recent years serum biomarkers have been proposed as a method that might enhance diagnostic capabilities and complement imaging studies. However, when used alone they show low sensitivity and specificity because lung cancer is a heterogeneous disease. Recent reports have shown that simultaneous analysis of biomarkers has the potential to separate lung cancer patients from control subjects. However, it has become clear that a universal biomarker panel does not exist, and optimized panels need to be developed and validated in each population before their application in a clinical setting. In this study, we selected 14 biomarkers from literature, whose diagnostic or prognostic value had been previously demonstrated for lung cancer, and evaluated them in sera from 63 patients with lung cancer and 87 non-cancer controls (58 Chronic Obstructive Pulmonary Disease (COPD) patients and 29 current smokers). Principal component analysis and artificial neural network modeling allowed us to find a reduced biomarker panel composed of Cyfra 21.1, CEA, CA125 and CRP. This panel was able to correctly classify 135 out of 150 subjects, showing a correct classification rate for lung cancer patients of 88.9%, 93.3% and 90% in training, validation and testing phases, respectively. Thus, sensitivity was increased 18.31% (sensitivity 94.5% at specificity 80%) with respect to the best single marker Cyfra 21.1. This optimized panel represents a potential tool for assisting lung cancer diagnosis, therefore it merits further consideration. © 2012 Elsevier Ltd. All rights reserved.


Quezada-Leon C.,Centro Medico ISSEMyM | Vazquez-Nino C.,Centro Medico ISSEMyM | Costilla-Montero A.,Centro Oncologico Estatal ISSEMyM | Hernandez-Alvarado J.,Centro Oncologico Estatal ISSEMyM
Revista Mexicana de Urologia | Year: 2016

Renal cell carcinoma represents 2-3% of all cancers and is the most frequent solid lesion of the kidney. Incidental diagnosis through imaging studies is approximately 50%, and the majority of those cases are asymptomatic. Management is based on radical surgical treatment and postoperative follow-up through imaging techniques is essential for detecting local or systemic recurrence.A 60-year-old man had a past history of left radical nephrectomy due to renal tumor 10 years earlier. Clinical manifestation was painless, gross hematuria. CT-urography revealed right ureteropelvic ectasia with a lesion occupying the distal third of the ureter that produced a negative filling defect. Endoscopic revision, lesion excision, and adjuvant treatment based on the tyrosine kinase inhibitor, sorafenib, were carried out.This clinical case underlines the importance of strict follow-up in patients with renal tumors when there is no clear knowledge as to the metastatic behavior and predictable tumor dissemination routes in renal cell carcinoma. © 2016.


Ocampo J.,Conducta | Valdez-Medina J.L.,Conducta | Gonzalez-Arratia N.I.,Conducta | Andrade-Palos P.,National Autonomous University of Mexico | And 2 more authors.
Revista Argentina de Clinica Psicologica | Year: 2011

The aim of the investigation was to know the degree of relation and the predictive capacity that the psychological variables, have to the quality of life in patients with breast cancer. 50 women in different phases of treatment participated. The Life Quality Inventory and Health (InCaViSa), the Coping Strategies Scale MOOS, the Resiliency Scale SV-RES, and the Multidimensional Scale of Religiousness/Spirituality were applied. A positive and significant relation between the quality of life with the coping and the resiliency was confirmed. The coping style by logical analysis and fortress predicted the quiality of life. The conclusion is that the coping and the resiliency included in intervention programs can increase the quality of life in patients with breast cancer. © 2011 Fundación AIGLÉ.


Ocampo Garcia K.G.,Centro Oncologico Estatal ISSEMyM | Dolores Velazquez R.,Centro Oncologico Estatal ISSEMyM | Barrera Franco J.L.,Centro Oncologico Estatal ISSEMyM | Heredia Salgado M.G.,National Autonomous University of Mexico | And 2 more authors.
Revista Espanola de Cirugia Oral y Maxilofacial | Year: 2013

The hemangioma is a benign vascular neoplasm frequently seen in early childhood, usually in females. Its location is common in the cervicofacial region in 60% of cases. This tumour represents a challenge for the health professional, as the major complications in these patients are bleeding disorders or obstructive airways. The clinical case presented is a 30 year old male patient with a diagnosis of a giant haemangioma arising from the orbicular muscle of the lip, treated with partial surgery and interferon, with no response or no real contribution. The volume of the haemangioma is currently increasing, causing a deformity on the left side of the face that exceeds the mandibular midline with subsequent oral alterations conditioned and aggravated by the disease itself, which is affecting his systemic health. © 2011 SECOM.


Dolores-Velazquez R.,Centro Oncologico Estatal ISSEMyM | Bustamante-Montes L.P.,National Autonomous University of Mexico | Romero-Fierro J.R.,Centro Oncologico Estatal ISSEMyM | Gomez-Plata E.,Centro Oncologico Estatal ISSEMyM | And 2 more authors.
Gaceta Mexicana de Oncologia | Year: 2014

Objective: To determine the clinical and histological features associated with CA-125 levels. Methods: The State Cancer Center records ISSEMyM 91 patients with diagnosis of epithelial ovarian cancer, of which CA-125 levels were obtained pretreatment, as well as the clinical and histological features of the tumor; values of CA-125 were log-normalized, analysis of variance, and t correlation test depending on the type of variable to be analyzed and finally a multiple regression model was carried out, all of this was used to identify predictors was performed CA-125 in the study population. Results: The presence of ascites, laterality, clinical stage, histological type and grade of differentiation show statistically significant associations with elevation of CA-125. We found that the number of pregnancies and the number of children was associated with increased CA-125 elevation, on the other hand, body mass index (BMI), tumor size and lymphovascular permeation showed no association with the elevation of this marker. The multiple regression model shows that the clinical stage, ascites, bilateral involvement, histologic type non-mucinous and poorly differentiated grade are the characteristics most CA-125 elevation. Conclusions: Clinical and histopathological, such as the presence of ascites, advanced clinical stage, bilaterality, differentiation grade and histological type are key features in the elevation of CA-125 determinants. 1665-9201 © 2014 Gaceta Mexicana de Oncología. Publicado por Masson Doyma México S.A. Todos los derechos reservados.


Ocampo-Garcia K.G.,Centro Oncologico Estatal ISSEMYM | Rojas-Calvillo A.,Centro Oncologico Estatal ISSEMYM | Dolores-Velazquez R.,Centro Oncologico Estatal ISSEMYM | Barrera-Franco J.L.,Centro Oncologico Estatal ISSEMYM | And 2 more authors.
Gaceta Mexicana de Oncologia | Year: 2011

Antecedents. Cancer has become a public health problem, which means that physicians has the necessity of use different methods to treat patients, one of them is chemotherapy. Chemotherapy agents have an specific toxicity for different levels, neurotoxicity could be related with Miofacial Syndrome Pain. Doxorubicin is a potent and effective antitumoral drug, it is used to treat solid and hematopoietic tumors, nevertheless accumulative and irreversible toxicity limit its clinical use. Objective. Know relationship between doxorubicin chemotherapy and Miofacial Syndrome Pain. Patients and methods. This study includes 88 patients that were treated with chemotherapy based on doxorubicin and had a symptom related with Miofacial Syndrome Pain. Patients were interrogated and explored to identify signs and symptoms of the syndrome. It was used chi-squared test (2) to probe independency between variables. Results. The frequency of Miofacial Syndrome Pain was 22.72%, women were more affected, 75% of the patients had diagnostic of breast cancer, the combination Doxorubicin+ Cyclophosphamide +Docetaxel was the most frequent. Chi-squared test (2) showed dependency between chemotherapy agents with myalgia and hypertonicity (p<0.05).


Allende-Perez S.,Jefatura de Cuidados Paliativos | Verastegui-Aviles E.,Servicio de Cuidados Paliativos | Mohar-Betancourt A.,Instituto Nacional Of Cancerologia | Arrieta-Rodriguez O.G.,Coordinacion del Area de Cancer de Pulmon | And 2 more authors.
Gaceta Mexicana de Oncologia | Year: 2013

The consensus was conducted with the purpose to include palliative care to the National Cancer Plan. Several decision markers involved in the national cancer plan, participated in the palliative care consensus. Health conditions in Mexico have improved in recent decades, as a result, there is an increase in life expectancy and the country is in an advanced stage of the demographic and epidemiological transition; therefore, chronic diseases have become the leading cause death. Palliative care is an urgent and global humanitarian need for people with cancer or other chronic diseases. Palliative care services should begin from the time of diagnosis and gradually adapt to the needs of patients and their families, must include the terminal stage of the disease and ideally support the family in their grief. This paper is the result of a meeting with some of the principal decision making actors in Mexican Oncology. © 2013 Gaceta Mexicana de Oncología. Publicado por Masson Doyma México S.A.


Flores J.M.,Research Center istencia En Tecnologia seno Del Estado Of Jalisco | Herrera E.,Research Center istencia En Tecnologia seno Del Estado Of Jalisco | Leal G.,Research Center istencia En Tecnologia seno Del Estado Of Jalisco | Gonzalez M.G.,Research Center istencia En Tecnologia seno Del Estado Of Jalisco | And 5 more authors.
IFMBE Proceedings | Year: 2013

Lung cancer diagnosis in early stages could be of paramount interest since patients may be treated opportunely decreasing the high death rate caused by this disease. A biomarker may describe abnormalities in the human being and may be correlated with a specific illness. Currently, no single biomarker reported has proved to be sufficiently specific and sensitive for lung cancer, thus the search is an open research issue. In this document a set of fourteen biomarkers were evaluated jointly for lung cancer detection, nevertheless, interpreting the information from these biomarkers is a quite complex task and powerful computational tools are required for proper data analysis. Thus an Artificial Neural Network was trained with a set of lung cancer biomarkers. Principal Component Analysis allowed reducing the biomarkers initial vector from fourteen to seven proteins. The Artificial Neural Network performed satisfactorily classifying correctly 60 out of 64 individuals. ANN trained with seven biomarkers -MMP-1, MMP-9, Cyfra 21-1, CRP, CEA, YKL-40, CA-125- yielded an increase in sensitivity of approximately 20%, i.e., 98.97%, compared with that of the best single biomarker, Cyfra 21-1 (sensitivity 78.9%). The corresponding specificity was 80%. ANN significantly improved the sensitivity of biomarkers, therefore ANN offers a promising auxiliary tool in diagnosis of lung cancer. © 2013 Springer.


Garcia-Fabela R.O.,Centro Oncologico Estatal ISSEMyM
Gaceta Mexicana de Oncologia | Year: 2010

Objective: This study examines the prevalence of depression in cancer patients and its association on several demographic variables. Method: 146 patients with cancer with different stages of the illness were studied using the Beck Depression Inventory with a cut-off point of >16. Results: The prevalence of depression among cancer patients was 36% with higher frecuency in females. The most frequently affected groups were from 30-44 years-old (16%, n=22) and from 45-64 years-old (17%, n=25). 57% of the patients dedicated exclusively to their home and the 82% located en palliative care suffer depression. Conclusions: the prevalence of depression among cancer patients is higher compared to the general population. Factors that diminished the probability of depression were: older age and paid work whether palliative care patients have higher risk.


Dolores-Velazquez R.,Centro Oncologico Estatal ISSEMYM | Gomez-Plata E.,Centro Oncologico Estatal ISSEMYM
Gaceta Mexicana de Oncologia | Year: 2014

Renal tumors constitute about 3% worldwide of all malignancies, the most frequent histological type is clear cell carcinoma (70%-80%), approximately 30% of these patients show metastatic disease in its presentation initial and 40% develop metastases during follow-up. The most frequent sites of metastasis include lung (50%-60%), bone (30%-40%) and brain (5%). Vagina cancer represents approximately 1%-2% of malignancies of the genital tract, the 91% of these are metastases, the majority of cases represent metastases from cervix, endometrium or colon, vagina metastasis from renal carcinoma is extremely rare. 1665-9201 © 2014 Gaceta Mexicana de Oncología. Publicado por Masson Doyma México S.A. Todos los derechos reservados.

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