Hematological, biochemical, respiratory, cardiovascular and electroneurophysiological parameters in African green monkeys (Cercopithecus aethiops sabaeus). Its use in non-clinical toxicological studies
Gonzalez B.,Centro Nacional Para La Produccion Of Animales Of Laboratorio Cenpalab |
Leon A.,Centro Nacional Para La Produccion Of Animales Of Laboratorio Cenpalab |
Arteaga M.E.,Centro Nacional Para La Produccion Of Animales Of Laboratorio Cenpalab |
Bada A.M.,Centro Nacional Para La Produccion Of Animales Of Laboratorio Cenpalab |
And 6 more authors.
Journal of Medical Primatology | Year: 2010
Background: The purpose of this study is to better characterize the hematological, biochemical, respiratory, cardiovascular and electroneurophysiological parameters in young adult Cercopithecus aethiops sabaeus of both sexes. The rhesus and cynomolgus monkeys are widely used as experimental primate models. However, only few articles have been published testing toxicological effects of pharmaceuticals on African green monkey. Methods: The present study was carried out with the recompilation of all parameters recorded before the first drug administration in five sub-chronic or chronic toxicological studies performed on 66 Cercopithecus aethiops sabaeus, born in Cuba. Results: This study provides hematological, biochemical, respiratory, cardiovascular and electroneurophysiological data for both choosing animals to be included into experiments and monitoring these parameters during the study. Conclusions: We conclude that this study provides valuable integrated data for determining the health status, including electroneurophysiological parameters, data not previously reported for this species, of the African green monkey. © 2010 John Wiley & Sons A/S.
Riera L.,National Center for the Breeding of Laboratory Animals |
Sosa L.,National Center for the Breeding of Laboratory Animals |
Fuentes D.,National Center for the Breeding of Laboratory Animals |
Perez L.M.,Centro Para El Control Estatal Of La Calidad Of Los Medicamentos Cecmed |
And 4 more authors.
Animal Technology and Welfare | Year: 2013
The procurement and breeding of experimental animals, their use, protection, welfare, microbiological categories and the establishment of ethical principles in experimentation, have been subjected to national and international regulations. In order to establish and standardise technical specifications related to these aspects, the Guide to Good Practice for the care, use and reproduction of experimental animals (BPCURAL) was developed. This document can be used as a national reference for verifying the per formance of good clinical and non-clinical practice and the activity of the Institutional Committees for the Care and Use of Laboratory Animals (IACUC) respecting to facilities, maintenance, care and use of animals, as well as, for the training and qualification of the related staff. The BPCURAL guide contains the following headings: Introduction, Definitions and Concepts, Reach and Responsibilities, Basic, Specific and Ethical Principles in animal experimentation, Institutional Programmes for the care, use and breeding of laboratory animals and bibliographic and reference annexes. This guide as a manual is par t of the quality management system for these experimental bio-models, allowing per formance of these tasks in the animal facility, vivariums and institutions that use animals in experiments. It meets what is established in the regulations, standards and national and international codes, making it applicable to all staff and structures, which because of their work, are directly or indirectly linked to the per formance of tasks for the breeding and use of experimental animals. Also, it will harmonise the principles and criteria used in the national system of experimental animals in Cuba, favouring the transparency in the process of inspections and accreditations.